UCSC S. cerevisiae Gene Sorter

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UCSC S. cerevisiae Gene Sorter

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#	Name	SGD ORF	Module	BLASTP E-Value	Genome Position	Description
1	AQY1	YPR192W	613	n/a	chrXVI 922,318	Spore-specific water channel that mediates the transport of water across cell membranes, developmentally controlled may play a role in spore maturation, probably by allowing water outflow, may be involved in freeze tolerance
2	KRE1	YNL322C	613	n/a	chrXIV 33,764	Cell wall glycoprotein involved in beta-glucan assembly serves as a K1 killer toxin membrane receptor
3	LSB5	YCL034W	613	n/a	chrIII 62,190	Protein of unknown function binds Las17p, which is a homolog of human Wiskott-Aldrich Syndrome protein involved in actin patch assembly and actin polymerization may mediate disassembly of the Pan1 complex from the endocytic coat
4	RAD51	YER095W	613	n/a	chrV 350,581	Strand exchange protein, forms a helical filament with DNA that searches for homology involved in the recombinational repair of double-strand breaks in DNA during vegetative growth and meiosis homolog of Dmc1p and bacterial RecA protein
5	MXR2	YCL033C	613	n/a	chrIII 63,029	Methionine-R-sulfoxide reductase, involved in the response to oxidative stress protects iron-sulfur clusters from oxidative inactivation along with MXR1 involved in the regulation of lifespan
6	YCL049C	YCL049C	613	n/a	chrIII 40,255	Protein of unknown function localizes to membrane fraction YCL049C is not an essential gene
7	PTC6	YCR079W	613	n/a	chrIII 253,509	Mitochondrial type 2C protein phosphatase (PP2C) with similarity to mammalian PP1Ks involved in mitophagy null mutant is sensitive to rapamycin and has decreased phosphorylation of the Pda1 subunit of pyruvate dehydrogenase
8	IMP2'	YIL154C	613	n/a	chrIX 54,501	Transcriptional activator involved in maintenance of ion homeostasis and protection against DNA damage caused by bleomycin and other oxidants, contains a C-terminal leucine-rich repeat
9	ASF2	YDL197C	613	n/a	chrIV 105,705	Anti-silencing protein that causes derepression of silent loci when overexpressed
10	PAU2	YEL049W	613	n/a	chrV 63,909	Member of the seripauperin multigene family encoded mainly in subtelomeric regions, active during alcoholic fermentation, regulated by anaerobiosis, negatively regulated by oxygen, repressed by heme
11	RGT1	YKL038W	613	n/a	chrXI 367,361	Glucose-responsive transcription factor that regulates expression of several glucose transporter (HXT) genes in response to glucose binds to promoters and acts both as a transcriptional activator and repressor
12	CSG2	YBR036C	613	n/a	chrII 309,697	Endoplasmic reticulum membrane protein, required for mannosylation of inositolphosphorylceramide and for growth at high calcium concentrations
13	SOR1	YJR159W	613	n/a	chrX 736,580	Sorbitol dehydrogenase expression is induced in the presence of sorbitol or xylose
14	YKR017C	YKR017C	613	n/a	chrXI 472,521	Putative protein of unknown function contains a RING finger motif
15	YBL086C	YBL086C	613	n/a	chrII 61,902	Protein of unknown function green fluorescent protein (GFP)-fusion protein localizes to the cell periphery
16	FZO1	YBR179C	613	n/a	chrII 587,830	Mitofusin integral membrane protein involved in mitochondrial outer membrane tethering and fusion role in mitochondrial genome maintenance efficient tethering and degradation of Fzo1p requires an intact N-terminal GTPase domain targeted for destruction by the ubiquitin ligase SCF-Mdm30p and the cytosolic ubiquitin-proteasome system
17	YMR262W	YMR262W	613	n/a	chrXIII 794,196	Protein of unknown function interacts weakly with Knr4p YMR262W is not an essential gene
18	GOS1	YHL031C	613	n/a	chrVIII 39,150	v-SNARE protein involved in Golgi transport, homolog of the mammalian protein GOS-28/GS28
19	PEX22	YAL055W	613	n/a	chrI 42,448	Putative peroxisomal membrane protein required for import of peroxisomal proteins, functionally complements a Pichia pastoris pex22 mutation
20	FMP52	YER004W	613	n/a	chrV 159,927	Protein of unknown function, localized to the mitochondrial outer membrane induced by treatment with 8-methoxypsoralen and UVA irradiation
21	HXT9	YJL219W	613	n/a	chrX 20,348	Putative hexose transporter that is nearly identical to Hxt11p, has similarity to major facilitator superfamily (MFS) transporters, expression of HXT9 is regulated by transcription factors Pdr1p and Pdr3p
22	TES1	YJR019C	613	n/a	chrX 467,756	Peroxisomal acyl-CoA thioesterase likely to be involved in fatty acid oxidation rather than fatty acid synthesis conserved protein also found in human peroxisomes TES1 mRNA levels increase during growth on fatty acids
23	YFL068W	YFL068W	613	n/a	chrVI 294	Putative protein of unknown function
24	PTR3	YFR029W	613	n/a	chrVI 211,955	Component of the SPS plasma membrane amino acid sensor system (Ssy1p-Ptr3p-Ssy5p), which senses external amino acid concentration and transmits intracellular signals that result in regulation of expression of amino acid permease genes
25	PHO23	YNL097C	613	2.0000000000000002e-159	chrXIV 441,862	Probable component of the Rpd3 histone deacetylase complex, involved in transcriptional regulation of PHO5 affects termination of snoRNAs and cryptic unstable transcripts (CUTs) C-terminus has similarity to human candidate tumor suppressor p33(ING1) and its isoform ING3
26	MRPS12	YNR036C	613	n/a	chrXIV 694,591	Mitochondrial protein may interact with ribosomes based on co-purification experiments similar to E. coli and human mitochondrial S12 ribosomal proteins
27	HAP5	YOR358W	613	n/a	chrXV 1,010,525	Subunit of the heme-activated, glucose-repressed Hap2/3/4/5 CCAAT-binding complex, a transcriptional activator and global regulator of respiratory gene expression required for assembly and DNA binding activity of the complex
28	RPN4	YDL020C	613	n/a	chrIV 415,910	Transcription factor that stimulates expression of proteasome genes Rpn4p levels are in turn regulated by the 26S proteasome in a negative feedback control mechanism RPN4 is transcriptionally regulated by various stress responses
29	AVO2	YMR068W	613	n/a	chrXIII 406,944	Component of a complex containing the Tor2p kinase and other proteins, which may have a role in regulation of cell growth
30	MSC3	YLR219W	613	n/a	chrXII 575,244	Protein of unknown function, green fluorescent protein (GFP)-fusion protein localizes to the cell periphery msc3 mutants are defective in directing meiotic recombination events to homologous chromatids potential Cdc28p substrate
31	ORM2	YLR350W	613	n/a	chrXII 829,055	Evolutionarily conserved protein, similar to Orm1p, required for resistance to agents that induce unfolded protein response Orm1p and Orm2p together control membrane biogenesis by coordinating lipid homeostasis with protein quality control
32	YLR326W	YLR326W	613	n/a	chrXII 782,535	Putative protein of unknown function, predicted to be palmitoylated
33	ASR1	YPR093C	613	n/a	chrXVI 719,991	Ubiquitin ligase that modifies and regulates RNA Pol II involved in a putative alcohol-responsive signaling pathway accumulates in the nucleus under alcohol stress contains a Ring/PHD finger domain similar to the mammalian rA9 protein
34	FRA1	YLL029W	613	n/a	chrXII 82,585	Protein involved in negative regulation of transcription of iron regulon forms an iron independent complex with Fra2p, Grx3p, and Grx4p cytosolic mutant fails to repress transcription of iron regulon and is defective in spore formation
35	YPR013C	YPR013C	613	n/a	chrXVI 585,108	Putative zinc finger protein YPR013C is not an essential gene
36	YGL072C	YGL072C	613	n/a	chrVII 371,182	Dubious open reading frame unlikely to encode a protein partially overlaps the verified gene HSF1 null mutant displays increased resistance to antifungal agents gliotoxin, cycloheximide and H2O2
37	YGL165C	YGL165C	613	n/a	chrVII 191,687	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data partially overlaps the verified ORF CUP2/YGL166W
38	YJL152W	YJL152W	613	n/a	chrX 136,353	Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data