UCSC S. cerevisiae Gene Sorter

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UCSC S. cerevisiae Gene Sorter

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#	Name	SGD ORF	Module	BLASTP E-Value	Genome Position	Description
1	ALD6	YPL061W	445	n/a	chrXVI 433,339	Cytosolic aldehyde dehydrogenase, activated by Mg2+ and utilizes NADP+ as the preferred coenzyme required for conversion of acetaldehyde to acetate constitutively expressed locates to the mitochondrial outer surface upon oxidative stress
2	HSP82	YPL240C	445	n/a	chrXVI 97,560	Hsp90 chaperone required for pheromone signaling and negative regulation of Hsf1p docks with Tom70p for mitochondrial preprotein delivery promotes telomerase DNA binding and nucleotide addition interacts with Cns1p, Cpr6p, Cpr7p, Sti1p
3	MET17	YLR303W	445	n/a	chrXII 733,209	Methionine and cysteine synthase (O-acetyl homoserine-O-acetyl serine sulfhydrylase), required for sulfur amino acid synthesis
4	SSA1	YAL005C	445	n/a	chrI 140,467	ATPase involved in protein folding and nuclear localization signal (NLS)-directed nuclear transport member of heat shock protein 70 (HSP70) family forms a chaperone complex with Ydj1p localized to the nucleus, cytoplasm, and cell wall 98% identical with Ssa2p, but subtle differences between the two proteins provide functional specificity with respect to propagation of yeast [URE3] prions and vacuolar-mediated degradations of gluconeogenesis enzymes
5	SSA2	YLL024C	445	n/a	chrXII 96,525	ATP binding protein involved in protein folding and vacuolar import of proteins member of heat shock protein 70 (HSP70) family associated with the chaperonin-containing T-complex present in the cytoplasm, vacuolar membrane and cell wall 98% identical with Ssa1p, but subtle differences between the two proteins provide functional specificity with respect to propagation of yeast [URE3] prions and vacuolar-mediated degradations of gluconeogenesis enzymes
6	HSC82	YMR186W	445	n/a	chrXIII 633,413	Cytoplasmic chaperone of the Hsp90 family, redundant in function and nearly identical with Hsp82p, and together they are essential expressed constitutively at 10-fold higher basal levels than HSP82 and induced 2-3 fold by heat shock
7	STI1	YOR027W	445	n/a	chrXV 381,937	Hsp90 cochaperone, interacts with the Ssa group of the cytosolic Hsp70 chaperones and activates Ssa1p ATPase activity interacts with Hsp90 chaperones and inhibits their ATPase activity homolog of mammalian Hop
8	KAR2	YJL034W	445	n/a	chrX 382,351	ATPase involved in protein import into the ER, also acts as a chaperone to mediate protein folding in the ER and may play a role in ER export of soluble proteins regulates the unfolded protein response via interaction with Ire1p
9	HSP60	YLR259C	445	n/a	chrXII 664,143	Tetradecameric mitochondrial chaperonin required for ATP-dependent folding of precursor polypeptides and complex assembly prevents aggregation and mediates protein refolding after heat shock role in mtDNA transmission phosphorylated
10	ADE2	YOR128C	445	n/a	chrXV 565,333	Phosphoribosylaminoimidazole carboxylase, catalyzes a step in the 'de novo' purine nucleotide biosynthetic pathway red pigment accumulates in mutant cells deprived of adenine
11	CWP1	YKL096W	445	n/a	chrXI 261,491	Cell wall mannoprotein that localizes specifically to birth scars of daughter cells, linked to a beta-1,3- and beta-1,6-glucan heteropolymer through a phosphodiester bond required for propionic acid resistance
12	SHM2	YLR058C	445	n/a	chrXII 258,696	Cytosolic serine hydroxymethyltransferase, converts serine to glycine plus 5,10 methylenetetrahydrofolate major isoform involved in generating precursors for purine, pyrimidine, amino acid, and lipid biosynthesis
13	HSP10	YOR020C	445	n/a	chrXV 370,684	Mitochondrial matrix co-chaperonin that inhibits the ATPase activity of Hsp60p, a mitochondrial chaperonin involved in protein folding and sorting in the mitochondria 10 kD heat shock protein with similarity to E. coli groES
14	DLD3	YEL071W	445	n/a	chrV 17,100	D-lactate dehydrogenase, part of the retrograde regulon which consists of genes whose expression is stimulated by damage to mitochondria and reduced in cells grown with glutamate as the sole nitrogen source, located in the cytoplasm
15	HOR2	YER062C	445	n/a	chrV 280,306	One of two redundant DL-glycerol-3-phosphatases (RHR2/GPP1 encodes the other) involved in glycerol biosynthesis induced in response to hyperosmotic stress and oxidative stress, and during the diauxic transition
16	GCV2	YMR189W	445	n/a	chrXIII 639,052	P subunit of the mitochondrial glycine decarboxylase complex, required for the catabolism of glycine to 5,10-methylene-THF expression is regulated by levels of 5,10-methylene-THF in the cytoplasm
17	ARI1	YGL157W	445	n/a	chrVII 209,527	NADPH-dependent aldehyde reductase, utilizes aromatic and alophatic aldehyde substrates member of the short-chain dehydrogenase/reductase superfamily
18	DIP5	YPL265W	445	n/a	chrXVI 41,956	Dicarboxylic amino acid permease, mediates high-affinity and high-capacity transport of L-glutamate and L-aspartate also a transporter for Gln, Asn, Ser, Ala, and Gly
19	CPR6	YLR216C	445	n/a	chrXII 572,653	Peptidyl-prolyl cis-trans isomerase (cyclophilin), catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues binds to Hsp82p and contributes to chaperone activity
20	ERO1	YML130C	445	n/a	chrXIII 12,328	Thiol oxidase required for oxidative protein folding in the endoplasmic reticulum
21	ADH6	YMR318C	445	0	chrXIII 911,602	NADPH-dependent medium chain alcohol dehydrogenase with broad substrate specificity member of the cinnamyl family of alcohol dehydrogenases may be involved in fusel alcohol synthesis or in aldehyde tolerance
22	AHA1	YDR214W	445	n/a	chrIV 893,401	Co-chaperone that binds to Hsp82p and activates its ATPase activity similar to Hch1p expression is regulated by stresses such as heat shock
23	YLR217W	YLR217W	445	n/a	chrXII 573,070	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data partially overlaps the verified gene CPR6