UCSC S. cerevisiae Gene Sorter

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UCSC S. cerevisiae Gene Sorter

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#	Name	SGD ORF	Module	BLASTP E-Value	Genome Position	Description
1	RPA190	YOR341W	451	n/a	chrXV 963,484	RNA polymerase I largest subunit A190
2	POL30	YBR088C	451	n/a	chrII 425,378	Proliferating cell nuclear antigen (PCNA), functions as the sliding clamp for DNA polymerase delta may function as a docking site for other proteins required for mitotic and meiotic chromosomal DNA replication and for DNA repair
3	RET1	YOR207C	451	n/a	chrXV 731,732	Second-largest subunit of RNA polymerase III, which is responsible for the transcription of tRNA and 5S RNA genes, and other low molecular weight RNAs
4	URK1	YNR012W	451	n/a	chrXIV 648,184	Uridine/cytidine kinase, component of the pyrimidine ribonucleotide salvage pathway that converts uridine into UMP and cytidine into CMP involved in the pyrimidine deoxyribonucleotide salvage pathway, converting deoxycytidine into dCMP
5	EFT1	YOR133W	451	n/a	chrXV 576,362	Elongation factor 2 (EF-2), also encoded by EFT2 catalyzes ribosomal translocation during protein synthesis contains diphthamide, the unique posttranslationally modified histidine residue specifically ADP-ribosylated by diphtheria toxin
6	DPH2	YKL191W	451	n/a	chrXI 81,837	Protein required, along with Dph1p, Kti11p, Jjj3p, and Dph5p, for synthesis of diphthamide, which is a modified histidine residue of translation elongation factor 2 (Eft1p or Eft2p) may act in a complex with Dph1p and Kti11p
7	CLB6	YGR109C	451	n/a	chrVII 705,930	B-type cyclin involved in DNA replication during S phase activates Cdc28p to promote initiation of DNA synthesis functions in formation of mitotic spindles along with Clb3p and Clb4p most abundant during late G1
8	ADE6	YGR061C	451	n/a	chrVII 613,927	Formylglycinamidine-ribonucleotide (FGAM)-synthetase, catalyzes a step in the 'de novo' purine nucleotide biosynthetic pathway
9	ILV3	YJR016C	451	n/a	chrX 465,329	Dihydroxyacid dehydratase, catalyzes third step in the common pathway leading to biosynthesis of branched-chain amino acids
10	RBG1	YAL036C	451	n/a	chrI 75,597	Member of the DRG family of GTP-binding proteins associates with translating ribosomes interacts with Tma46p, Ygr250cp, Gir2p and Yap1p via two-hybrid
11	POL5	YEL055C	451	n/a	chrV 50,005	DNA Polymerase phi has sequence similarity to the human MybBP1A and weak sequence similarity to B-type DNA polymerases, not required for chromosomal DNA replication required for the synthesis of rRNA
12	NUG1	YER006W	451	n/a	chrV 163,504	GTPase that associates with nuclear 60S pre-ribosomes, required for export of 60S ribosomal subunits from the nucleus
13	YER156C	YER156C	451	n/a	chrV 483,833	Putative protein of unknown function interacts with Hsp82p and copurifies with Ipl1p expression is copper responsive and downregulated in strains deleted for MAC1, a copper-responsive transcription factor similarity to mammalian MYG1
14	CYB5	YNL111C	451	n/a	chrXIV 417,121	Cytochrome b5, involved in the sterol and lipid biosynthesis pathways acts as an electron donor to support sterol C5-6 desaturation
15	ELP2	YGR200C	451	n/a	chrVII 901,087	Subunit of Elongator complex, which is required for modification of wobble nucleosides in tRNA target of Kluyveromyces lactis zymocin
16	RPA43	YOR340C	451	n/a	chrXV 959,692	RNA polymerase I subunit A43
17	MTR4	YJL050W	451	n/a	chrX 344,132	ATP-dependent 3'-5' RNA helicase of the Dead-box family, involved in nuclear RNA processing and degradation both as a component of the TRAMP complex and in TRAMP independent processes has a KOW domain that shows RNA binding activity
18	NOP9	YJL010C	451	n/a	chrX 418,562	Essential subunit of U3-containing 90S preribosome involved in production of 18S rRNA and assembly of small ribosomal subunit also part of pre-40S ribosome and required for its export into cytoplasm binds RNA and contains pumilio domain
19	HMS2	YJR147W	451	n/a	chrX 704,734	Protein with similarity to heat shock transcription factors overexpression suppresses the pseudohyphal filamentation defect of a diploid mep1 mep2 homozygous null mutant
20	FAA4	YMR246W	451	n/a	chrXIII 760,849	Long chain fatty acyl-CoA synthetase, activates imported fatty acids with a preference for C12:0-C16:0 chain lengths functions in long chain fatty acid import important for survival during stationary phase localized to lipid particles
21	TCB2	YNL087W	451	n/a	chrXIV 464,179	Bud-specific protein with a potential role in membrane trafficking GFP-fusion protein migrates from the cell surface to intracellular vesicles near vacuole contains 3 calcium and lipid binding domains mRNA is targeted to the bud
22	UTP22	YGR090W	451	n/a	chrVII 664,214	Possible U3 snoRNP protein involved in maturation of pre-18S rRNA, based on computational analysis of large-scale protein-protein interaction data
23	ATF2	YGR177C	451	n/a	chrVII 849,632	Alcohol acetyltransferase, may play a role in steroid detoxification forms volatile esters during fermentation, which is important for brewing and winemaking
24	MKC7	YDR144C	451	n/a	chrIV 745,206	GPI-anchored aspartyl protease, member of the yapsin family of proteases involved in cell wall growth and maintenance shares functions with Yap3p and Kex2p
25	DBP6	YNR038W	451	n/a	chrXIV 696,539	Essential protein involved in ribosome biogenesis putative ATP-dependent RNA helicase of the DEAD-box protein family
26	TRM112	YNR046W	451	n/a	chrXIV 707,991	Subunit of tRNA methyltransferase (MTase) complexes in combination with Trm9p and Trm11p subunit of complex with Mtq2p that methylates Sup45p (eRF1) in the ternary complex eRF1-eRF3-GTP deletion confers resistance to zymocin
27	NOG2	YNR053C	451	n/a	chrXIV 722,116	Putative GTPase that associates with pre-60S ribosomal subunits in the nucleolus and is required for their nuclear export and maturation
28	ESF2	YNR054C	451	n/a	chrXIV 723,831	Essential nucleolar protein involved in pre-18S rRNA processing binds to RNA and stimulates ATPase activity of Dbp8 involved in assembly of the small subunit (SSU) processome
29	YNL024C	YNL024C	451	n/a	chrXIV 587,477	Putative protein of unknown function with seven beta-strand methyltransferase motif green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm YNL024C is not an essential gene
30	YVH1	YIR026C	451	n/a	chrIX 405,420	Protein phosphatase involved in vegetative growth at low temperatures, sporulation, and glycogen accumulation mutants are defective in 60S ribosome assembly member of the dual-specificity family of protein phosphatases
31	PLB2	YMR006C	451	n/a	chrXIII 278,621	Phospholipase B (lysophospholipase) involved in phospholipid metabolism displays transacylase activity in vitro overproduction confers resistance to lysophosphatidylcholine
32	YDR161W	YDR161W	451	n/a	chrIV 779,624	Putative protein of unknown function non-essential gene proposed function in rRNA and ribosome biosynthesis based on transcriptional co-regulation genetic interactions suggest a role in ER-associated protein degradation (ERAD)
33	SXM1	YDR395W	451	n/a	chrIV 1,264,741	Nuclear transport factor (karyopherin) involved in protein transport between the cytoplasm and nucleoplasm similar to Nmd5p, Cse1p, Lph2p, and the human cellular apoptosis susceptibility protein, CAS1
34	RRN11	YML043C	451	n/a	chrXIII 191,005	Component of the core factor (CF) rDNA transcription factor complex CF is required for transcription of 35S rRNA genes by RNA polymerase I and is composed of Rrn6p, Rrn7p, and Rrn11p
35	NOP8	YOL144W	451	n/a	chrXV 53,825	Nucleolar protein required for 60S ribosomal subunit biogenesis
36	ETT1	YOR051C	451	n/a	chrXV 425,465	Nuclear protein that inhibits replication of Brome mosaic virus in S. cerevisiae, which is a model system for studying replication of positive-strand RNA viruses in their natural hosts deletion increases stop codon readthrough
37	NOB1	YOR056C	451	n/a	chrXV 430,936	Essential nuclear protein involved in proteasome maturation and synthesis of 40S ribosomal subunits required for cleavage of the 20S pre-rRNA to generate the mature 18S rRNA
38	TMA46	YOR091W	451	n/a	chrXV 493,951	Protein of unknown function that associates with translating ribosomes interacts with GTPase Rbg1p
39	YOL092W	YOL092W	451	n/a	chrXV 144,667	Putative protein of unknown function predicted to contain six transmembrane domains and is 58% similar to the uncharacterized ORF YBR147W
40	MAK21	YDR060W	451	n/a	chrIV 572,187	Constituent of 66S pre-ribosomal particles, required for large (60S) ribosomal subunit biogenesis involved in nuclear export of pre-ribosomes required for maintenance of dsRNA virus homolog of human CAATT-binding protein
41	TRM13	YOL125W	451	n/a	chrXV 84,549	2'-O-methyltransferase responsible for modification of tRNA at position 4 C-terminal domain has similarity to Rossmann-fold (RFM) superfamily of RNA methyltransferases
42	NOP14	YDL148C	451	0	chrIV 189,370	Nucleolar protein, forms a complex with Noc4p that mediates maturation and nuclear export of 40S ribosomal subunits also present in the small subunit processome complex, which is required for processing of pre-18S rRNA
43	YDL152W	YDL152W	451	n/a	chrIV 183,004	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data partially overlaps the verified ORF SAS10/YDL153C, a component of the small ribosomal subunit processosome