UCSC S. cerevisiae Gene Sorter

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UCSC S. cerevisiae Gene Sorter

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#	Name	SGD ORF	Module	BLASTP E-Value	Genome Position	Description
1	CYB2	YML054C	415	n/a	chrXIII 166,420	Cytochrome b2 (L-lactate cytochrome-c oxidoreductase), component of the mitochondrial intermembrane space, required for lactate utilization expression is repressed by glucose and anaerobic conditions
2	FBP1	YLR377C	415	n/a	chrXII 874,269	Fructose-1,6-bisphosphatase, key regulatory enzyme in the gluconeogenesis pathway, required for glucose metabolism undergoes either proteasome-mediated or autophagy-mediated degradation depending on growth conditions interacts with Vid30p
3	PCK1	YKR097W	415	n/a	chrXI 631,976	Phosphoenolpyruvate carboxykinase, key enzyme in gluconeogenesis, catalyzes early reaction in carbohydrate biosynthesis, glucose represses transcription and accelerates mRNA degradation, regulated by Mcm1p and Cat8p, located in the cytosol
4	SPS100	YHR139C	415	n/a	chrVIII 378,709	Protein required for spore wall maturation expressed during sporulation may be a component of the spore wall expression also induced in cells treated with the mycotoxin patulin
5	HAP4	YKL109W	415	n/a	chrXI 233,059	Subunit of the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex, a transcriptional activator and global regulator of respiratory gene expression provides the principal activation function of the complex
6	CTA1	YDR256C	415	n/a	chrIV 968,906	Catalase A, breaks down hydrogen peroxide in the peroxisomal matrix formed by acyl-CoA oxidase (Pox1p) during fatty acid beta-oxidation
7	PUT4	YOR348C	415	n/a	chrXV 987,840	Proline permease, required for high-affinity transport of proline also transports the toxic proline analog azetidine-2-carboxylate (AzC) PUT4 transcription is repressed in ammonia-grown cells
8	ADY2	YCR010C	415	n/a	chrIII 132,698	Acetate transporter required for normal sporulation phosphorylated in mitochondria
9	ICL1	YER065C	415	n/a	chrV 286,077	Isocitrate lyase, catalyzes the formation of succinate and glyoxylate from isocitrate, a key reaction of the glyoxylate cycle expression of ICL1 is induced by growth on ethanol and repressed by growth on glucose
10	MLS1	YNL117W	415	n/a	chrXIV 407,190	Malate synthase, enzyme of the glyoxylate cycle, involved in utilization of non-fermentable carbon sources expression is subject to carbon catabolite repression localizes in peroxisomes during growth in oleic acid medium
11	ACH1	YBL015W	415	n/a	chrII 194,912	Protein with CoA transferase activity, particularly for CoASH transfer from succinyl-CoA to acetate has minor acetyl-CoA-hydrolase activity phosphorylated required for acetate utilization and for diploid pseudohyphal growth
12	SFC1	YJR095W	415	n/a	chrX 610,257	Mitochondrial succinate-fumarate transporter, transports succinate into and fumarate out of the mitochondrion required for ethanol and acetate utilization
13	YKL187C	YKL187C	415	n/a	chrXI 90,410	Putative protein of unknown function the authentic, non-tagged protein is detected in a phosphorylated state in highly purified mitochondria in high-throughput studies
14	YKL107W	YKL107W	415	n/a	chrXI 236,605	Putative protein of unknown function proposed to be a palmitoylated membrane protein
15	MTH1	YDR277C	415	n/a	chrIV 1,015,051	Negative regulator of the glucose-sensing signal transduction pathway, required for repression of transcription by Rgt1p interacts with Rgt1p and the Snf3p and Rgt2p glucose sensors phosphorylated by Yck1p, triggering Mth1p degradation
16	JEN1	YKL217W	415	n/a	chrXI 23,159	Monocarboxylate/proton symporter of the plasma membrane transport activity is dependent on the pH gradient across the membrane mediates high-affinity uptake of carbon sources lactate, pyuvate, and acetate, and also of the micronutrient selenite, whose structure mimics that of monocarboxylates expression and localization are tightly regulated, with transcription repression, mRNA degradation, and protein endocytosis and degradation all occurring in the presence of glucose
17	ECM13	YBL043W	415	n/a	chrII 137,074	Non-essential protein of unknown function induced by treatment with 8-methoxypsoralen and UVA irradiation
18	STL1	YDR536W	415	n/a	chrIV 1,508,859	Glycerol proton symporter of the plasma membrane, subject to glucose-induced inactivation, strongly but transiently induced when cells are subjected to osmotic shock
19	RGI2	YIL057C	415	n/a	chrIX 248,149	Protein of unknown function involved in energy metabolism under respiratory conditions expression induced under carbon limitation and repressed under high glucose
20	CRS5	YOR031W	415	n/a	chrXV 389,317	Copper-binding metallothionein, required for wild-type copper resistance
21	PXA1	YPL147W	415	n/a	chrXVI 274,561	Subunit of a heterodimeric peroxisomal ATP-binding cassette transporter complex (Pxa1p-Pxa2p), required for import of long-chain fatty acids into peroxisomes similarity to human adrenoleukodystrophy transporter and ALD-related proteins
22	IDP2	YLR174W	415	n/a	chrXII 505,210	Cytosolic NADP-specific isocitrate dehydrogenase, catalyzes oxidation of isocitrate to alpha-ketoglutarate levels are elevated during growth on non-fermentable carbon sources and reduced during growth on glucose
23	AGX1	YFL030W	415	n/a	chrVI 77,409	Alanine:glyoxylate aminotransferase (AGT), catalyzes the synthesis of glycine from glyoxylate, which is one of three pathways for glycine biosynthesis in yeast has similarity to mammalian and plant alanine:glyoxylate aminotransferases
24	SIP4	YJL089W	415	n/a	chrX 267,170	C6 zinc cluster transcriptional activator that binds to the carbon source-responsive element (CSRE) of gluconeogenic genes involved in the positive regulation of gluconeogenesis regulated by Snf1p protein kinase localized to the nucleus
25	NCA3	YJL116C	415	n/a	chrX 194,366	Protein that functions with Nca2p to regulate mitochondrial expression of subunits 6 (Atp6p) and 8 (Atp8p ) of the Fo-F1 ATP synthase member of the SUN family expression induced in cells treated with the mycotoxin patulin
26	SPG1	YGR236C	415	n/a	chrVII 962,673	Protein required for survival at high temperature during stationary phase not required for growth on nonfermentable carbon sources the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
27	SIP18	YMR175W	415	n/a	chrXIII 611,135	Phospholipid-binding hydrophilin with a role in dessication resistance expression is induced by osmotic stress
28	YGR067C	YGR067C	415	n/a	chrVII 623,579	Putative protein of unknown function contains a zinc finger motif similar to that of Adr1p
29	YNL144C	YNL144C	415	n/a	chrXIV 353,931	Putative protein of unknown function non-tagged protein is detected in highly purified mitochondria in high-throughput studies contains a PH domain and binds phosphatidylinositols and phosphatidylethanolamine in a large-scale study
30	ACS1	YAL054C	415	n/a	chrI 43,951	Acetyl-coA synthetase isoform which, along with Acs2p, is the nuclear source of acetyl-coA for histone acetylation expressed during growth on nonfermentable carbon sources and under aerobic conditions
31	YMR206W	YMR206W	415	n/a	chrXIII 676,366	Putative protein of unknown function YMR206W is not an essential gene
32	SPG4	YMR107W	415	4e-64	chrXIII 483,187	Protein required for survival at high temperature during stationary phase not required for growth on nonfermentable carbon sources
33	SNO4	YMR322C	415	n/a	chrXIII 918,722	Possible chaperone and cysteine protease, similar to bacterial Hsp31 and yeast Hsp31p, Hsp32p, and Hsp33p DJ-1/ThiJ/PfpI superfamily member predicted involvement in pyridoxine metabolism induced by mild heat stress and copper deprivation
34	YLR164W	YLR164W	415	n/a	chrXII 494,136	Mitochondrial inner membrane protein of unknown function similar to Tim18p and Sdh4p expression induced by nitrogen limitation in a GLN3, GAT1-dependent manner
35	NDE2	YDL085W	415	n/a	chrIV 304,029	Mitochondrial external NADH dehydrogenase, catalyzes the oxidation of cytosolic NADH Nde1p and Nde2p are involved in providing the cytosolic NADH to the mitochondrial respiratory chain
36	HSP33	YOR391C	415	n/a	chrXV 1,078,901	Possible chaperone and cysteine protease with similarity to E. coli Hsp31 and S. cerevisiae Hsp31p, Hsp32p, and Sno4p member of the DJ-1/ThiJ/PfpI superfamily, which includes human DJ-1 involved in Parkinson's disease
37	YIG1	YPL201C	415	n/a	chrXVI 170,462	Protein that interacts with glycerol 3-phosphatase and plays a role in anaerobic glycerol production localizes to the nucleus and cytosol
38	GRE1	YPL223C	415	n/a	chrXVI 128,885	Hydrophilin of unknown function stress induced (osmotic, ionic, oxidative, heat shock and heavy metals) regulated by the HOG pathway
39	CRC1	YOR100C	415	n/a	chrXV 513,786	Mitochondrial inner membrane carnitine transporter, required for carnitine-dependent transport of acetyl-CoA from peroxisomes to mitochondria during fatty acid beta-oxidation
40	CSR2	YPR030W	415	n/a	chrXVI 629,562	Nuclear protein proposed to regulate utilization of nonfermentable carbon sources and endocytosis of plasma membrane proteins overproduction suppresses chs5 spa2 lethality at high temp ubiquitinated by Rsp5p, deubiquitinated by Ubp2p
41	YLR311C	YLR311C	415	n/a	chrXII 757,438	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
42	YBR051W	YBR051W	415	n/a	chrII 338,163	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data partiallly overlaps the REG2/YBR050C regulatory subunit of the Glc7p type-1 protein phosphatase