UCSC S. cerevisiae Gene Sorter

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UCSC S. cerevisiae Gene Sorter

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#	Name	SGD ORF	Module	BLASTP E-Value	Genome Position	Description
1	TRP2	YER090W	397	n/a	chrV 338,710	Anthranilate synthase, catalyzes the initial step of tryptophan biosynthesis, forms multifunctional hetero-oligomeric anthranilate synthase:indole-3-glycerol phosphate synthase enzyme complex with Trp3p
2	TRP3	YKL211C	397	n/a	chrXI 37,426	Bifunctional enzyme exhibiting both indole-3-glycerol-phosphate synthase and anthranilate synthase activities, forms multifunctional hetero-oligomeric anthranilate synthase:indole-3-glycerol phosphate synthase enzyme complex with Trp2p
3	DPS1	YLL018C	397	n/a	chrXII 110,738	Aspartyl-tRNA synthetase, primarily cytoplasmic homodimeric enzyme that catalyzes the specific aspartylation of tRNA(Asp) class II aminoacyl tRNA synthetase binding to its own mRNA may confer autoregulation
4	RHO2	YNL090W	397	n/a	chrXIV 456,854	Non-essential small GTPase of the Rho/Rac subfamily of Ras-like proteins, involved in the establishment of cell polarity and in microtubule assembly
5	TOM70	YNL121C	397	n/a	chrXIV 399,610	Component of the TOM (translocase of outer membrane) complex responsible for recognition and initial import steps for all mitochondrially directed proteins acts as a receptor for incoming precursor proteins
6	RPB2	YOR151C	397	n/a	chrXV 614,834	RNA polymerase II second largest subunit B150, part of central core similar to bacterial beta subunit
7	ARO1	YDR127W	397	n/a	chrIV 706,867	Pentafunctional arom protein, catalyzes steps 2 through 6 in the biosynthesis of chorismate, which is a precursor to aromatic amino acids
8	TUB1	YML085C	397	n/a	chrXIII 98,670	Alpha-tubulin associates with beta-tubulin (Tub2p) to form tubulin dimer, which polymerizes to form microtubules
9	TUB3	YML124C	397	n/a	chrXIII 22,865	Alpha-tubulin associates with beta-tubulin (Tub2p) to form tubulin dimer, which polymerizes to form microtubules expressed at lower level than Tub1p
10	MAS2	YHR024C	397	n/a	chrVIII 158,468	Larger subunit of the mitochondrial processing protease (MPP), essential processing enzyme that cleaves the N-terminal targeting sequences from mitochondrially imported proteins
11	NAT1	YDL040C	397	n/a	chrIV 380,156	Subunit of the N-terminal acetyltransferase NatA (Nat1p, Ard1p, Nat5p) N-terminally acetylates many proteins, which influences multiple processes such as the cell cycle, heat-shock resistance, mating, sporulation, and telomeric silencing
12	KEX2	YNL238W	397	n/a	chrXIV 203,650	Subtilisin-like protease (proprotein convertase), a calcium-dependent serine protease involved in the activation of proproteins of the secretory pathway
13	SEC63	YOR254C	397	n/a	chrXV 806,027	Essential subunit of Sec63 complex (Sec63p, Sec62p, Sec66p and Sec72p) with Sec61 complex, Kar2p/BiP and Lhs1p forms a channel competent for SRP-dependent and post-translational SRP-independent protein targeting and import into the ER
14	SEC23	YPR181C	397	n/a	chrXVI 898,514	GTPase-activating protein, stimulates the GTPase activity of Sar1p component of the Sec23p-Sec24p heterodimer of the COPII vesicle coat, involved in ER to Golgi transport
15	PFK1	YGR240C	397	n/a	chrVII 972,252	Alpha subunit of heterooctameric phosphofructokinase involved in glycolysis, indispensable for anaerobic growth, activated by fructose-2,6-bisphosphate and AMP, mutation inhibits glucose induction of cell cycle-related genes
16	VMA1	YDL185W	397	n/a	chrIV 128,394	Subunit A of the eight-subunit V1 peripheral membrane domain of the vacuolar H+-ATPase protein precursor undergoes self-catalyzed splicing to yield the extein Tfp1p and the intein Vde (PI-SceI), which is a site-specific endonuclease
17	MYO2	YOR326W	397	n/a	chrXV 928,083	One of two type V myosin motors (along with MYO4) involved in actin-based transport of cargos required for the polarized delivery of secretory vesicles, the vacuole, late Golgi elements, peroxisomes, and the mitotic spindle
18	DBP5	YOR046C	397	n/a	chrXV 415,183	Cytoplasmic ATP-dependent RNA helicase of the DEAD-box family involved in mRNA export from the nucleus involved in translation termination ATP/ADP cycling is regulated by Gle1p and Nup159p
19	YCK2	YNL154C	397	n/a	chrXIV 344,456	Palmitoylated plasma membrane-bound casein kinase I isoform shares redundant functions with Yck1p in morphogenesis, proper septin assembly, endocytic trafficking provides an essential function overlapping with that of Yck1p
20	SPT6	YGR116W	397	n/a	chrVII 722,586	Transcription elongation factor required for the maintenance of chromatin structure during transcription in order to inhibit transcription from promoters within the coding region
21	MSH2	YOL090W	397	0	chrXV 148,829	Protein that forms heterodimers with Msh3p and Msh6p that bind to DNA mismatches to initiate the mismatch repair process contains a Walker ATP-binding motif required for repair activity Msh2p-Msh6p binds to and hydrolyzes ATP
22	CAM1	YPL048W	397	n/a	chrXVI 465,024	Nuclear protein required for transcription of MXR1 binds the MXR1 promoter in the presence of other nuclear factors binds calcium and phospholipids has similarity to translational cofactor EF-1 gamma
23	SEC21	YNL287W	397	n/a	chrXIV 93,397	Gamma subunit of coatomer, a heptameric protein complex that together with Arf1p forms the COPI coat involved in ER to Golgi transport of selective cargo
24	PRO3	YER023W	397	n/a	chrV 201,506	Delta 1-pyrroline-5-carboxylate reductase, catalyzes the last step in proline biosynthesis
25	SAC1	YKL212W	397	n/a	chrXI 35,478	Phosphatidylinositol phosphate (PtdInsP) phosphatase involved in hydrolysis of PtdIns[4]P transmembrane protein localizes to ER and Golgi involved in protein trafficking and processing, secretion, and cell wall maintenance
26	CDC3	YLR314C	397	n/a	chrXII 763,356	Component of the septin ring of the mother-bud neck that is required for cytokinesis septins recruit proteins to the neck and can act as a barrier to diffusion at the membrane, and they comprise the 10nm filaments seen with EM
27	HOG1	YLR113W	397	n/a	chrXII 372,273	Mitogen-activated protein kinase involved in osmoregulation acts via three independent osmosensors mitophagy-specific regulator mediates the recruitment and activation of RNA Pol II at Hot1p-dependent promoters localization regulated by Ptp2p and Ptp3p
28	NDC1	YML031W	397	n/a	chrXIII 215,172	Nuclear envelope protein with multiple putative transmembrane domains, required for nuclear pore complex assembly and spindle pole body duplication required for meiosis II
29	SPT16	YGL207W	397	n/a	chrVII 100,522	Subunit of the heterodimeric FACT complex (Spt16p-Pob3p), which associates with chromatin via interaction with Nhp6Ap and Nhp6Bp, and reorganizes nucleosomes to facilitate access to DNA by RNA and DNA polymerases
30	VPH1	YOR270C	397	n/a	chrXV 829,313	Subunit a of vacuolar-ATPase V0 domain, one of two isoforms (Vph1p and Stv1p) Vph1p is located in V-ATPase complexes of the vacuole while Stv1p is located in V-ATPase complexes of the Golgi and endosomes
31	PUB1	YNL016W	397	n/a	chrXIV 603,587	Poly (A)+ RNA-binding protein, abundant mRNP-component protein that binds mRNA and is required for stability of many mRNAs component of glucose deprivation induced stress granules, involved in P-body-dependent granule assembly
32	PTR2	YKR093W	397	n/a	chrXI 616,632	Integral membrane peptide transporter, mediates transport of di- and tri-peptides conserved protein that contains 12 transmembrane domains PTR2 expression is regulated by the N-end rule pathway via repression by Cup9p
33	SRP101	YDR292C	397	n/a	chrIV 1,044,078	Signal recognition particle (SRP) receptor alpha subunit contain GTPase domains involved in SRP-dependent protein targeting interacts with the beta subunit, Srp102p
34	CSE1	YGL238W	397	n/a	chrVII 50,993	Nuclear envelope protein that mediates the nuclear export of importin alpha (Srp1p), homolog of metazoan CAS protein, required for accurate chromosome segregation
35	NIC96	YFR002W	397	n/a	chrVI 151,275	Component of the nuclear pore complex, required for nuclear pore formation forms a subcomplex with Nsp1p, Nup57p, and Nup49p
36	STO1	YMR125W	397	n/a	chrXIII 518,992	Large subunit of the nuclear mRNA cap-binding protein complex, interacts with Npl3p to carry nuclear poly(A)+ mRNA to cytoplasm also involved in nuclear mRNA degradation and telomere maintenance orthologous to mammalian CBP80
37	NUP120	YKL057C	397	n/a	chrXI 332,412	Subunit of the Nup84p subcomplex of the nuclear pore complex (NPC) required for even distribution of NPCs around the nuclear envelope, involved in establishment of a normal nucleocytoplasmic concentration gradient of the GTPase Gsp1p the Nup84 subcomplex has a role in transcription elongation
38	DEF1	YKL054C	397	n/a	chrXI 337,645	RNAPII degradation factor, forms a complex with Rad26p in chromatin, enables ubiquitination and proteolysis of RNAPII present in an elongation complex mutant is deficient in Zip1p loading onto chromosomes during meiosis
39	PXL1	YKR090W	397	n/a	chrXI 610,006	LIM domain-containing protein that localizes to sites of polarized growth, required for selection and/or maintenance of polarized growth sites, may modulate signaling by the GTPases Cdc42p and Rho1p has similarity to metazoan paxillin
40	GEF1	YJR040W	397	n/a	chrX 508,915	Voltage-gated chloride channel localized to the golgi, the endosomal system, and plasma membrane, and involved in cation homeostasis highly homologous to vertebrate voltage-gated chloride channels
41	AAP1	YHR047C	397	n/a	chrVIII 200,025	Arginine/alanine aminopeptidase, overproduction stimulates glycogen accumulation
42	ISW1	YBR245C	397	n/a	chrII 709,844	Member of the imitation-switch (ISWI) class of ATP-dependent chromatin remodeling complexes ATPase that forms a complex with Ioc2p and Ioc4p to regulate transcription elongation, and a complex with Ioc3p to repress transcription initiation
43	SRP68	YPL243W	397	n/a	chrXVI 89,416	Core component of the signal recognition particle (SRP) ribonucleoprotein (RNP) complex that functions in targeting nascent secretory proteins to the endoplasmic reticulum (ER) membrane
44	SFB3	YHR098C	397	n/a	chrVIII 300,539	Component of the Sec23p-Sfb3p heterodimer of the COPII vesicle coat, required for cargo selection during vesicle formation in ER to Golgi transport homologous to Sec24p and Sfb2p
45	GGA2	YHR108W	397	n/a	chrVIII 329,181	Protein that interacts with and regulates Arf1p and Arf2p in a GTP-dependent manner to facilitate traffic through the late Golgi binds phosphatidylinositol 4-phosphate, which plays a role in TGN localization has homology to gamma-adaptin
46	STT3	YGL022W	397	n/a	chrVII 453,482	Subunit of the oligosaccharyltransferase complex of the ER lumen, which catalyzes asparagine-linked glycosylation of newly synthesized proteins forms a subcomplex with Ost3p and Ost4p and is directly involved in catalysis
47	CCT2	YIL142W	397	n/a	chrIX 84,093	Subunit beta of the cytosolic chaperonin Cct ring complex, related to Tcp1p, required for the assembly of actin and tubulins in vivo
48	NUP157	YER105C	397	n/a	chrV 369,925	Abundant subunit of the nuclear pore complex (NPC), present on both sides of the NPC has similarity to Nup170p essential role, with Nup170p, in NPC assembly
49	TMN3	YER113C	397	n/a	chrV 388,992	Protein with a role in cellular adhesion and filamentous growth similar to Emp70p and Tmn2p member of Transmembrane Nine family with 9 transmembrane segments localizes to Golgi induced by 8-methoxypsoralen plus UVA irradiation
50	MET18	YIL128W	397	n/a	chrIX 115,355	DNA repair and TFIIH regulator, required for both nucleotide excision repair (NER) and RNA polymerase II (RNAP II) transcription involved in telomere maintenance