UCSC S. cerevisiae Gene Sorter

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UCSC S. cerevisiae Gene Sorter

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#	Name	SGD ORF	Module	BLASTP E-Value	Genome Position	Description
1	CAR1	YPL111W	517	n/a	chrXVI 340,444	Arginase, responsible for arginine degradation, expression responds to both induction by arginine and nitrogen catabolite repression disruption enhances freeze tolerance
2	HIS4	YCL030C	517	n/a	chrIII 67,133	Multifunctional enzyme containing phosphoribosyl-ATP pyrophosphatase, phosphoribosyl-AMP cyclohydrolase, and histidinol dehydrogenase activities catalyzes the second, third, ninth and tenth steps in histidine biosynthesis
3	GCN4	YEL009C	517	n/a	chrV 139,340	Basic leucine zipper (bZIP) transcriptional activator of amino acid biosynthetic genes in response to amino acid starvation expression is tightly regulated at both the transcriptional and translational levels
4	ADE4	YMR300C	517	n/a	chrXIII 866,325	Phosphoribosylpyrophosphate amidotransferase (PRPPAT amidophosphoribosyltransferase), catalyzes first step of the 'de novo' purine nucleotide biosynthetic pathway
5	CAN1	YEL063C	517	n/a	chrV 32,580	Plasma membrane arginine permease, requires phosphatidyl ethanolamine (PE) for localization, exclusively associated with lipid rafts mutation confers canavanine resistance
6	ADE3	YGR204W	517	n/a	chrVII 907,354	Cytoplasmic trifunctional enzyme C1-tetrahydrofolate synthase, involved in single carbon metabolism and required for biosynthesis of purines, thymidylate, methionine, and histidine null mutation causes auxotrophy for adenine and histidine
7	GDH1	YOR375C	517	n/a	chrXV 1,042,360	NADP(+)-dependent glutamate dehydrogenase, synthesizes glutamate from ammonia and alpha-ketoglutarate rate of alpha-ketoglutarate utilization differs from Gdh3p expression regulated by nitrogen and carbon sources
8	LEU1	YGL009C	517	n/a	chrVII 477,482	Isopropylmalate isomerase, catalyzes the second step in the leucine biosynthesis pathway
9	MET3	YJR010W	517	n/a	chrX 457,006	ATP sulfurylase, catalyzes the primary step of intracellular sulfate activation, essential for assimilatory reduction of sulfate to sulfide, involved in methionine metabolism
10	ARG8	YOL140W	517	n/a	chrXV 59,394	Acetylornithine aminotransferase, catalyzes the fourth step in the biosynthesis of the arginine precursor ornithine
11	ADE1	YAR015W	517	n/a	chrI 169,835	N-succinyl-5-aminoimidazole-4-carboxamide ribotide (SAICAR) synthetase, required for 'de novo' purine nucleotide biosynthesis red pigment accumulates in mutant cells deprived of adenine
12	TIP1	YBR067C	517	n/a	chrII 372,419	Major cell wall mannoprotein with possible lipase activity transcription is induced by heat- and cold-shock member of the Srp1p/Tip1p family of serine-alanine-rich proteins
13	CTS1	YLR286C	517	n/a	chrXII 709,292	Endochitinase, required for cell separation after mitosis transcriptional activation during the G1 phase of the cell cycle is mediated by transcription factor Ace2p
14	CYS3	YAL012W	517	n/a	chrI 131,391	Cystathionine gamma-lyase, catalyzes one of the two reactions involved in the transsulfuration pathway that yields cysteine from homocysteine with the intermediary formation of cystathionine
15	MET22	YOL064C	517	n/a	chrXV 206,639	Bisphosphate-3'-nucleotidase, involved in salt tolerance and methionine biogenesis dephosphorylates 3'-phosphoadenosine-5'-phosphate and 3'-phosphoadenosine-5'-phosphosulfate, intermediates of the sulfate assimilation pathway
16	GLN1	YPR035W	517	n/a	chrXVI 642,764	Glutamine synthetase (GS), synthesizes glutamine from glutamate and ammonia with Glt1p, forms the secondary pathway for glutamate biosynthesis from ammonia expression regulated by nitrogen source and by amino acid limitation
17	OAC1	YKL120W	517	n/a	chrXI 217,831	Mitochondrial inner membrane transporter, transports oxaloacetate, sulfate, thiosulfate, and isopropylmalate member of the mitochondrial carrier family
18	AGA2	YGL032C	517	n/a	chrVII 436,701	Adhesion subunit of a-agglutinin of a-cells, C-terminal sequence acts as a ligand for alpha-agglutinin (Sag1p) during agglutination, modified with O-linked oligomannosyl chains, linked to anchorage subunit Aga1p via two disulfide bonds
19	TYE7	YOR344C	517	n/a	chrXV 977,631	Serine-rich protein that contains a basic-helix-loop-helix (bHLH) DNA binding motif binds E-boxes of glycolytic genes and contributes to their activation may function as a transcriptional activator in Ty1-mediated gene expression
20	PDR3	YBL005W	517	n/a	chrII 218,935	Transcriptional activator of the pleiotropic drug resistance network, regulates expression of ATP-binding cassette (ABC) transporters through binding to cis-acting sites known as PDREs (PDR responsive elements)
21	PDR5	YOR153W	517	n/a	chrXV 622,107	Plasma membrane ATP-binding cassette (ABC) transporter, multidrug transporter actively regulated by Pdr1p also involved in steroid transport, cation resistance, and cellular detoxification during exponential growth
22	SER1	YOR184W	517	n/a	chrXV 679,950	3-phosphoserine aminotransferase, catalyzes the formation of phosphoserine from 3-phosphohydroxypyruvate, required for serine and glycine biosynthesis regulated by the general control of amino acid biosynthesis mediated by Gcn4p
23	CTP1	YBR291C	517	n/a	chrII 784,122	Mitochondrial inner membrane citrate transporter, member of the mitochondrial carrier family
24	GGC1	YDL198C	517	n/a	chrIV 104,100	Mitochondrial GTP/GDP transporter, essential for mitochondrial genome maintenance has a role in mitochondrial iron transport member of the mitochondrial carrier family
25	LYS9	YNR050C	517	n/a	chrXIV 714,718	Saccharopine dehydrogenase (NADP+, L-glutamate-forming) catalyzes the formation of saccharopine from alpha-aminoadipate 6-semialdehyde, the seventh step in lysine biosynthesis pathway exhibits genetic and physical interactions with TRM112
26	MXR1	YER042W	517	n/a	chrV 235,214	Methionine-S-sulfoxide reductase, involved in the response to oxidative stress protects iron-sulfur clusters from oxidative inactivation along with MXR2 involved in the regulation of lifespan
27	YER064C	YER064C	517	n/a	chrV 283,463	Non-essential nuclear protein null mutation has global effects on transcription
28	LYS12	YIL094C	517	n/a	chrIX 187,074	Homo-isocitrate dehydrogenase, an NAD-linked mitochondrial enzyme required for the fourth step in the biosynthesis of lysine, in which homo-isocitrate is oxidatively decarboxylated to alpha-ketoadipate
29	BAP3	YDR046C	517	n/a	chrIV 549,669	Amino acid permease involved in the uptake of cysteine, leucine, isoleucine and valine
30	GZF3	YJL110C	517	0	chrX 210,749	GATA zinc finger protein and Dal80p homolog that negatively regulates nitrogen catabolic gene expression by competing with Gat1p for GATA site binding function requires a repressive carbon source dimerizes with Dal80p and binds to Tor1p
31	MET5	YJR137C	517	n/a	chrX 681,121	Sulfite reductase beta subunit, involved in amino acid biosynthesis, transcription repressed by methionine
32	GNP1	YDR508C	517	n/a	chrIV 1,467,448	High-affinity glutamine permease, also transports Leu, Ser, Thr, Cys, Met and Asn expression is fully dependent on Grr1p and modulated by the Ssy1p-Ptr3p-Ssy5p (SPS) sensor of extracellular amino acids
33	RNR4	YGR180C	517	n/a	chrVII 855,782	Ribonucleotide-diphosphate reductase (RNR), small subunit the RNR complex catalyzes the rate-limiting step in dNTP synthesis and is regulated by DNA replication and DNA damage checkpoint pathways via localization of the small subunits
34	MUP1	YGR055W	517	n/a	chrVII 600,279	High affinity methionine permease, integral membrane protein with 13 putative membrane-spanning regions also involved in cysteine uptake
35	RIB4	YOL143C	517	n/a	chrXV 54,849	Lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, also known as DMRL synthase) catalyzes synthesis of immediate precursor to riboflavin
36	TPO2	YGR138C	517	n/a	chrVII 764,684	Polyamine transport protein specific for spermine localizes to the plasma membrane transcription of TPO2 is regulated by Haa1p member of the major facilitator superfamily
37	ZPR1	YGR211W	517	n/a	chrVII 915,971	Essential protein with two zinc fingers, present in the nucleus of growing cells but relocates to the cytoplasm in starved cells via a process mediated by Cpr1p binds to translation elongation factor eEF-1 (Tef1p)
38	NRK1	YNL129W	517	n/a	chrXIV 381,841	Nicotinamide riboside kinase, catalyzes the phosphorylation of nicotinamide riboside and nicotinic acid riboside in salvage pathways for NAD+ biosynthesis
39	ERG5	YMR015C	517	n/a	chrXIII 301,677	C-22 sterol desaturase, a cytochrome P450 enzyme that catalyzes the formation of the C-22(23) double bond in the sterol side chain in ergosterol biosynthesis may be a target of azole antifungal drugs
40	HHT2	YNL031C	517	n/a	chrXIV 575,845	Histone H3, core histone protein required for chromatin assembly, part of heterochromatin-mediated telomeric and HM silencing one of two identical histone H3 proteins (see HHT1) regulated by acetylation, methylation, and phosphorylation
41	ADE12	YNL220W	517	n/a	chrXIV 235,063	Adenylosuccinate synthase, catalyzes the first step in synthesis of adenosine monophosphate from inosine 5'monophosphate during purine nucleotide biosynthesis exhibits binding to single-stranded autonomously replicating (ARS) core sequence
42	NPL3	YDR432W	517	n/a	chrIV 1,329,405	RNA-binding protein that promotes elongation, regulates termination, and carries poly(A) mRNA from nucleus to cytoplasm required for pre-mRNA splicing dissociation from mRNAs promoted by Mtr10p phosphorylated by Sky1p in the cytoplasm
43	MTD1	YKR080W	517	n/a	chrXI 590,876	NAD-dependent 5,10-methylenetetrahydrafolate dehydrogenase, plays a catalytic role in oxidation of cytoplasmic one-carbon units expression is regulated by Bas1p and Bas2p, repressed by adenine, and may be induced by inositol and choline
44	MET14	YKL001C	517	n/a	chrXI 439,081	Adenylylsulfate kinase, required for sulfate assimilation and involved in methionine metabolism
45	ADE13	YLR359W	517	n/a	chrXII 845,006	Adenylosuccinate lyase, catalyzes two steps in the 'de novo' purine nucleotide biosynthetic pathway expression is repressed by adenine and activated by Bas1p and Pho2p mutations in human ortholog ADSL cause adenylosuccinase deficiency
46	TPO3	YPR156C	517	n/a	chrXVI 838,843	Polyamine transport protein specific for spermine localizes to the plasma membrane member of the major facilitator superfamily
47	ENB1	YOL158C	517	n/a	chrXV 20,401	Endosomal ferric enterobactin transporter, expressed under conditions of iron deprivation member of the major facilitator superfamily expression is regulated by Rcs1p and affected by chloroquine treatment
48	AUS1	YOR011W	517	n/a	chrXV 351,771	Plasma membrane sterol transporter of the ATP-binding cassette family required, along with Pdr11p, for uptake of exogenous sterols and their incorporation into the plasma membrane activity is stimulated by phosphatidylserine sterol uptake is required for anaerobic growth because sterol biosynthesis requires oxygen
49	SAM3	YPL274W	517	n/a	chrXVI 23,819	High-affinity S-adenosylmethionine permease, required for utilization of S-adenosylmethionine as a sulfur source has similarity to S-methylmethionine permease Mmp1p
50	RPS30A	YLR287C-A	517	n/a	chrXII 712,847	Protein component of the small (40S) ribosomal subunit nearly identical to Rps30Bp and has similarity to rat S30 ribosomal protein