Affine Alignment
 
Alignment between MEGF6 (top ENST00000356575.9 1541aa) and NOTCH2 (bottom ENST00000256646.7 2471aa) score 22287

0128 CSASLCFHGGRCVPGSAQ-PCHCPPGFQGPRCQYDVDECRTHNGGCQH--RCVNTPGSYL 0184
     | +  | +|  |   + |  | |  || | +|+ ||+||    | |||   |+| |||| 
0148 CLSHPCANGSTCTTVANQFSCKCLTGFTGQKCETDVNECDI-PGHCQHGGTCLNLPGSYQ 0206

0185 CECKPGFR-LHTDS-RTCLAINSCALGNGGCQHHCVQLTITRHRCQCRPGFQLQEDGRHC 0242
     |+|  ||   + ||     | + |   |||    | |       | | |||    +|  |
0207 CQCPQGFTGQYCDSLYVPCAPSPCV--NGGT---CRQTGDFTFECNCLPGF----EGSTC 0257

0243 VRR-SPCANRNGSCMHRCQ----VVRGLARCECHVGYQLAADGKAC-EDVDECAAGLAQC 0296
      |    | |      ||||     | |+    |    |    |+ | ||||||      |
0258 ERNIDDCPN------HRCQNGGVCVDGVNTYNCRCPPQWT--GQFCTEDVDECLLQPNAC 0309

0297 AHG--CLNTQGSFKCVCHAGYELGADGRQCYRIEMEIVNSCEANNGGCSHG--CSHTSAG 0352
      +|  | |  | + |||  |+     |  |     | ++ |      |+ |  |    | 
0310 QNGGTCANRNGGYGCVCVNGW----SGDDC----SENIDDCAF--ASCTPGSTCIDRVAS 0359

0353 PLCTCPRGYELDTDQRTCIDVDDCADSPCCQ-QVCTNNP--GGYECGCYAGYRLSADGCG 0409
       | || |         |   | |  +|| +  +|  ||  | | | |  ||+    |  
0360 FSCMCPEG----KAGLLCHLDDACISNPCHKGALCDTNPLNGQYICTCPQGYK----GAD 0411

0410 C-EDVDECASSRGG-CEH--HCTNLAGSFQCSCEAGY---RLHEDRRGC--SPLEEPMVD 0460
     | ||||||| +    |||   | |  |+| | |  ||   |   |   |   | +     
0412 CTEDVDECAMANSNPCEHAGKCVNTDGAFHCECLKGYAGPRCEMDINECHSDPCQNDATC 0471

0461 LDGELPFV-RPLPHIAVLQDELPQLFQDDDVGADEEEAELRGEHTL--TEKFVCL--DDS 0515
     ||    |    +|    +  ||       ++   +    +     +    +| ||     
0472 LDKIGGFTCLCMPGFKGVHCEL-------EINECQSNPCVNNGQCVDKVNRFQCLCPPGF 0524

0516 FGHDCSLTCDDCR-----NGGTCLLGLDG--CDCPEGWTGLICNE---TCPPDTFGKNCS 0565
      |  | +  |||      ||  |+   +|  | |  |+||++| |    | ||     | 
0525 TGPVCQIDIDDCSSTPCLNGAKCIDHPNGYECQCATGFTGVLCEENIDNCDPDP----CH 0580

0566 FSCSCQNGGTCDSVTGACRCPPGVSGTNCEDGCPKGYYGKHCRKKCNCANRGRCHRLYGA 0625
         ||+|   || |  | | ||  |  | |   + |          | | |||  |   
0581 HG-QCQDG--IDSYT--CICNPGYMGAICSDQIDECY-------SSPCLNDGRCIDLVNG 0628

0626 --CLCDPGLYGRFCHLTCPPWAFGPGCSEECQCVQPHTQSCDKRDG----SCSCKAGFRG 0679
       | | ||  |  | +     |  |     |             ||    || |  || |
0629 YQCNCQPGTSGVNCEINFDDCASNPCIHGICM------------DGINRYSCVCSPGFTG 0676

0680 ERCQAECELGYFGPGCWQACTCPVGV--------------ACDSVSGEC------GKRCP 0719
     +||  + +     | | +  ||  ||              +| |   ||         | 
0677 QRCNIDIDECASNP-CRKGATCINGVNGFRCICPEGPHHPSCYSQVNECLSNPCIHGNCT 0735

0720 AGFQGEDCGQECPVGTFGVNC--------SSSCSCGGAPCHGVTG-QCRCPPGRTGEDCE 0770
      |  |  |   |  |  |+||        |+ |  ||   + | | +| |  |  | +|+
0736 GGLSGYKC--LCDAGWVGINCEVDKNECLSNPCQNGGTCDNLVNGYRCTCKKGFKGYNCQ 0793

0771 AD--------------CPEGRWGLGCQEICP----------------ACQHAARCDP--- 0797
      +              | +   |  |  + |                 |++|| |     
0794 VNIDECASNPCLNQGTCFDDISGYTCHCVLPYTGKNCQTVLAPCSPNPCENAAVCKESPN 0853

0798 -ETGACLCLPGFVGSRCQ-DVCPAGWYGPSCQTRCSCANDGHCHPATGH--CSCAPGWTG 0853
      |+  ||| ||+ | ||  |+         | ++  | | | ||   |   | | ||++|
0854 FESYTCLCAPGWQGQRCTIDI-------DECISK-PCMNHGLCHNTQGSYMCECPPGFSG 0905

0854 FSCQRACDTGHWGPDC-SHPCNCSAGHGSC-DAISGL-CLCEAGYVGPRCEQQCPQGHFG 0910
       |+   |      || ++||      ||| | ++   |||  |+ | +|+    +    
0906 MDCEEDID------DCLANPCQ---NGGSCMDGVNTFSCLCLPGFTGDKCQTDMNECLSE 0956

0911 PGCEQRCQCQHGAAC-DHV-SGACTCPAGWRGTFCEHACPAGFFGLDCRSACNCTAGAAC 0968
     |       |++|  | |+| |  | | ||+ |  ||+         +|  +     |   
0957 P-------CKNGGTCSDYVNSYTCKCQAGFDGVHCENNIN------ECTESSCFNGGTCV 1003

0969 DAVNG-SCLCPAGRRGPRCAETCPAHTYGHNCSQACACFNGASCDPVHGQCHCAPGWMGP 1027
     | +|  ||||| |  |  |          + || +  | |  +|    |   |       
1004 DGINSFSCLCPVGFTGSFCLHEI------NECS-SHPCLNEGTCVDGLGTYRC------- 1049

1028 SCLQACPAGLYGDNCR---HSCL---CQNGGTC--DPVSGHCACPEGWAGLACEKECLPR 1079
         +|| |  | ||+   + |    |+| |||        | || ||||  |+   +  
1050 ----SCPLGYTGKNCQTLVNLCSRSPCKNKGTCVQKKAESQCLCPSGWAGAYCDVPNVSC 1105

1080 DVRAG---------CRHSGGCLNGGLCDPHTGRCLCPAGWTGDKCQSPCLRGWFGEACAQ 1130
     |+ |          |+||| |+| |    +|  | || |+||  |+         + || 
1106 DIAASRRGVLVEHLCQHSGVCINAG----NTHYCQCPLGYTGSYCEEQL------DECAS 1155

1131 RCSCPPGAACHHVTGA--CRCPPGFTGSGCEQACPPGSFGEDCA-QMCQCPGENPACHPA 1187
        |  || |    |   | | ||+ |  ||         ++|  | ||  |    |   
1156 N-PCQHGATCSDFIGGYRCECVPGYQGVNCEYEV------DECQNQPCQNGG---TCIDL 1205

1188 TG--TCSCAAGYHGPSCQQRCPPGRYGPGCEQLCGCLNGGSCDAATG--ACRCPTGFLGT 1243
          |||  |  |  |++       ||       ||||| |    |  +|||  || | 
1206 VNHFKCSCPPGTRGLLCEENIDDCARGP------HCLNGGQCMDRIGGYSCRCLPGFAGE 1259

1244 DCNLTCPQGRFGPNCTHVCGCGQGAACDPVTGTCLCPPGRAGVRCERGCPQNRFGVGCEH 1303
      |     +|      ++ |       |  +|                           ++
1260 RC-----EGDINECLSNPCSSEGSLDCIQLTN--------------------------DY 1288

1304 TCSCRNGGLCHASNGSCSCGLGWTGRHCEL---ACPPGRYGAACHLECSCHNNSTCEPAT 1360
      | ||+                +||||||     ||          +  | |  ||  |+
1289 LCVCRS---------------AFTGRHCETFVDVCP----------QMPCLNGGTCAVAS 1323

1361 GTCRCGPGFYGQACEHPCPPGFHGAGCQGLCW---CQHGAPC-DPISG-RCLCPAGFHGH 1415
           |   |  |   ||||| || ||  |    |+ |  |    || || ||+     
1324 NM----PD--GFICR--CPPGFSGARCQSSCGQVKCRKGEQCVHTASGPRCFCPS---PR 1372

1416 FCERGC--EPGSFGEGCHQR-------CDCD---GGAPCDPVTGLCLCPPGRSGATCNLD 1463
      || ||   |   |  || +       | |     |+ |+    |   ||    |||   
1373 DCESGCASSPCQHGGSCHPQRQPPYYSCQCAPPFSGSRCE----LYTAPPSTPPATCLSQ 1428

1464 -----CRRGQFGPSCTLHCDCGGGADC 1485
           | |    +|  |     | ||
1429 YCADKARDGVCDEACNSHACQWDGGDC 1455