Alignment between ARHGEF16 (top ENST00000378378.9 709aa) and ARHGEF5 (bottom ENST00000056217.10 1597aa) score 14516

0143 GMLRRNLRNQSYRAAMKGLGKPGGQGDAIQLSPKLQALAEEPSQPHTRSPAKNKKTLGR- 0201
     |  |+ ||    | ++   |    +| |++  |        ||        | |+ +|  
1034 GWSRQGLR----RPSILPEGSSDSRGPAVEKHP-------GPSDTVVFREKKPKEVMGGF 1082

0202 KRGHKGSFKDDPQLYQEIQERGLNTSQESDD--DILDESSSPEGTQKVDATIVVK----- 0254
      |           ||||  +  ||   +|    + | |+  |   ++    +|       
1083 SRRCSKLINSSQLLYQEYSDVVLNKEIQSQQRLESLSETPGPSSPRQPRKALVSSESYLQ 1142

0255 --SYRPAQVTWSQLPEVVELGILDQLSTEERKRQEAMFEILTSEFSYQHSLSILVEEFLQ 0312
       |   +   | ++| |    +|  ++ |++| ||  ||++ || ||  ||+| |+ |  
1143 RLSMASSGSLWQEIPVVRNSTVLLSMTHEDQKLQEVKFELIVSEASYLRSLNIAVDHFQL 1202

0313 SKELRATVTQMEHHHLFSNILDVLGASQRFFEDLEQRHKAQVLVEDISDILEEHAEKHFH 0372
     |  ||||++  ||  ||| + ||   |  |  |||+  +  +    + |++  ||     
1203 STSLRATLSNQEHQWLFSRLQDVRDVSATFLSDLEENFENNIFSFQVCDVVLNHAPDFRR 1262

0373 PYIAYCSNEVYQQRTLQKLISSNAAFREALREIERRPACGGLPMLSFLILPMQRVTRLPL 0432
      |+ | +|+ ||+|| | |++||+ ||| | ++|  | |  | + |||||| ||+||| |
1263 VYLPYVTNQTYQERTFQSLMNSNSNFREVLEKLESDPVCQRLSLKSFLILPFQRITRLKL 1322

0433 LMDTLCLKTQGHSERYKAASRALKAISKLVRQCNEGAHRMERMEQMYTLHTQLDFSKVKS 0492
     |+  +  +||  |     |++|  |+ +|+| ||     | | |++  |  +++| + | 
1323 LLQNILKRTQPGSSEEAEATKAHHALEQLIRDCNNNVQSMRRTEELIYLSQKIEF-ECKI 1381

0493 LPLISASRWLLKRGELFLVE---ETGLFRKIASRPTCYLFLFNDVLVVTKKKSEESYMVQ 0549
      |||| ||||+| |||  +|     || ||+ +||  +| |||| |++++ +    ++| 
1382 FPLISQSRWLVKSGELTALEFSASPGLRRKLNTRPV-HLHLFNDCLLLSRPREGSRFLVF 1440

0550 DYAQMNHIQVEKIEPSELPLPGGGNRSSSVPHP--FQVTLLRNSEGRQEQLLLSSDSASD 0607
     |+|  + |+ ||    |+ | |        ||   |++ | +|++| | + |  +++ |+
1441 DHAPFSSIRGEK---CEMKLHG--------PHKNLFRLFLRQNTQGAQAEFLFRTETQSE 1489

0608 RARWIVALTHSERQWQGLSSKGDLPQVEITKAFFAKQADEVTLQQADVVLVLQQ-EDGWL 0666
     + ||| ||    |+   |    + |||+  +|+  ++ ||+ |++||||+| ||  ||||
1490 KLRWISALA-MPREELDLLECYNSPQVQCLRAYKPRENDELALEKADVVMVTQQSSDGWL 1548

0667 YGERLRDGETGWFPEDFARFITSRVAVEGNVRRMERLR 0704
      | || ||| ||||     ||++      |++   |++
1549 EGVRLSDGERGWFPVQQVEFISNPEVRAQNLKEAHRVK 1586