Affine Alignment
 
Alignment between SCN4A (top ENST00000435607.3 1836aa) and CACNA1S (bottom ENST00000362061.4 1873aa) score 26334

0110 ALYLLSPFSVVRRGAIKVLIHALFSMFIMITILTNCVFMTMSDPPPWSKN---------V 0160
     ||+ |+  + +|+  | ++    |   |++||  ||| + +  | |   |         +
0030 ALFCLTLENPLRKACISIVEWKPFETIILLTIFANCVALAVYLPMPEDDNNSLNLGLEKL 0089

0161 EYTFTGIYTFESLIKILARGFCVDDFTFLRDPWNWLDFSVIMMAYLTEFVDLGN------ 0214
     || |  +++ |+ +||+| ||      +||  || |||+++ +   |  ++  |      
0090 EYFFLIVFSIEAAMKIIAYGFLFHQDAYLRSGWNVLDFTIVFLGVFTVILEQVNVIQSHT 0149

0215 -----------ISALRTFRVLRALKTITVIPGLKTIVGALIQSVKKLSDVMILTVFCLSV 0263
                + ||| ||||| |+ ++ +| |+ ++ ++ +++  |  + +| +| + +
0150 APMSSKGAGLDVKALRAFRVLRPLRLVSGVPSLQVVLNSIFKAMLPLFHIALLVLFMVII 0209

0264 FALVGLQLFMGNLRQKCVRWPPPFNDTNTTWYSNDTWYGNDTWYGNEMWYGNDSWYANDT 0323
     +|++||+|| | + + |                   + | |                   
0210 YAIIGLELFKGKMHKTCY------------------FIGTDI------------------ 0233

0324 WNSHASWATNDTFDWDAYISDEGNFYFLEGSNDALLCGNSSDAGHCP-EGYECIKTGRNP 0382
                     | + +|          +   |  +     |   | ||      |
0234 ---------------VATVENE----------EPSPCARTGSGRRCTINGSECRGGWPGP 0268

0383 NYGYTSYDTFSWAFLALFRLMTQDYWENLFQLTLRAAGKTY-MIFFVVIIFLGSFYLINL 0441
     |+| | +| | ++ | +++ +| + | ++      | |  +  |+|| +| ||||+++||
0269 NHGITHFDNFGFSMLTVYQCITMEGWTDVLYWVNDAIGNEWPWIYFVTLILLGSFFILNL 0328

0442 ILAVVAMAYAEQNEATLAEDK-EKEEEFQQMLEKFKKHQEELEKAKAAQALEGGEADGDP 0500
     +| |++  + ++ |   +    +|  | ||+ |  + +   + + +     +  |     
0329 VLGVLSGEFTKEREKAKSRGTFQKLREKQQLDEDLRGYMSWITQGEVMDVEDFRE----- 0383

0501 AHGKDCNGSLDTSQGEKGAPRQSSSGDSGISDAMEELEEAHQKCPPWWYKCAHKVLIWNC 0560
            | |   +|  |+  +|    +|++  ++ +    |    |     +++  | |
0384 -------GKLSLDEG--GSDTESLYEIAGLNKIIQFIRHWRQ----W-----NRIFRWKC 0425

0561 CAPWLKFKNIIHLIVMDPFVDLGITICIVLNTLFMAMEHYPMTEHFDNVLTVGNLVFTGI 0620
                | ||        + + + |||| +| ||+        +  + | |   +
0426 -----------HDIVKSKVFYWLVILIVALNTLSIASEHHNQPLWLTRLQDIANRVLLSL 0474

0621 FTAEMVLKLIAMDPYEYFQQGWNIFDSIIV-----TLSLVELGLANVQGLSVLRSFRLLR 0675
     || ||++|+  +   +||   +| ||  +|      + ||| |     |+||||  ||||
0475 FTTEMLMKMYGLGLRQYFMSIFNRFDCFVVCSGILEILLVESGAMTPLGISVLRCIRLLR 0534

0676 VFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKECVCKIAL 0735
     +||+ | | +|+ |+  + ||+ ++ +| |+| + + |||++||||||  |         
0535 IFKITKYWTSLSNLVASLLNSIRSIASLLLLLFLFIVIFALLGMQLFGGRYD------FE 0588

0736 DCNLPRWHMHDFFHSFLIVFRILCGE-WIETMWDCM------EVAGQAMCLTVFLMVMVI 0788
     |  + | +  +|  + + ||++| || |   |++ +         |  +|+  |+++ | 
0589 DTEVRRSNFDNFPQALISVFQVLTGEDWTSMMYNGIMAYGGPSYPGMLVCI-YFIILFVC 0647

0789 GNLVVLNLFLALLLSSFSADSLAASDEDGEMNNLQIAIGRIKLGIGFAKAFLLGLLHGKI 0848
     || ++||+|||+     + |+|| ++                         |      | 
0648 GNYILLNVFLAI-----AVDNLAEAES------------------------LTSAQKAKA 0678

0849 LSPKDIMLSLGEADGAGEAGEAGETAPEDEKKEPPEEDLKKDNHILNHMGLADGPPSSLE 0908
        |   +| |  | + |  |    | + |+|   |                 | |++ +
0679 EEKKRRKMSKGLPDKSEE--EKSTMAKKLEQKPKGE-----------------GIPTTAK 0719

0909 L------DHLNFINNPYLTIQVPIASEESDLEMPTEEETDTFSEPEDSKKPPQPLYDGNS 0962
     |       ++| + +|| +   |   || + |+|                 |+||     
0720 LKIDEFESNVNEVKDPYPSADFPGDDEEDEPEIPLSPR-------------PRPL----- 0761

0963 SVCSTADYKPPEEDPEEQAEENPEGEQPEECFTEACVQRWPCLYVDISQGRGKKWWTLRR 1022
                |   +|+|   ||                   ++     +      +| 
0762 ----------AELQLKEKAVPIPEASS---------------FFIFSPTNK------IRV 0790

1023 ACFKIVEHNWFETFIVFMILLSSGALAFEDIYIEQRRVIRTILEYADKVFTYIFIMEMLL 1082
      | +||   ||  ||+  ||||| ||| ||  |    +   ||++ |  || +| +|++|
0791 LCHRIVNATWFTNFILLFILLSSAALAAED-PIRADSMRNQILKHFDIGFTSVFTVEIVL 0849

1083 KWVAYGFKV----YFTNAWCWLDFLIVDVSIISLVANWLGYSELGPIKSLRTLRALRPLR 1138
     |   ||  +    +  | +  || |+| ||+||+    |  | +  +| || || |||||
0850 KMTTYGAFLHKGSFCRNYFNMLDLLVVAVSLISM---GLESSAISVVKILRVLRVLRPLR 0906

1139 ALSRFEGMRVVVNALLGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYYC--INTTTSE 1196
     |++| +|++ ||  +  || +| |++||  +   +|+ +|| || |||+ |  ++  | |
0907 AINRAKGLKHVVQCMFVAISTIGNIVLVTTLLQFMFACIGVQLFKGKFFRCTDLSKMTEE 0966

1197 R----FDISEVNNKSECESLMHTGQVRWLNVKVNYDNVGLGYLSLLQVATFKGWMDIMYA 1252
          + + +  +  + | | |     |++   ++|||    +||  |+||+||  ++| 
0967 ECRGYYYVYKDGDPMQIE-LRHR---EWVHSDFHFDNVLSAMMSLFTVSTFEGWPQLLYK 1022

1253 AVDSREKEEQPQYEVNLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKLGGKDIFM 1312
     |+||  ++  | |   + | ++|+|+||  +|| +|+|+| +|  | +|     |+  + 
1023 AIDSNAEDVGPIYNNRVEMAIFFIIYIILIAFFMMNIFVGFVIVTFQEQ-----GETEYK 1077

1313 TEEQKKYYNAMKKLGSKKPQKPIPRPQNKIQGMVYDLVTKQAFDITIMILICLNMVTMMV 1372
       |  |      +   |        |+|  |  |+ +||   |+  +  || || + + +
1078 NCELDKNQRQCVQYALKARPLRCYIPKNPYQYQVWYIVTSSYFEYLMFALIMLNTICLGM 1137

1373 ETDNQSQLKVDILYNINMIFIIIFTGECVLKMLALR-QYYFTVGWNIFDFVVVILSIVGL 1431
     +  |||+    |   +|+ | |||| | +||++| + + ||   ||+|||++|| ||+ +
1138 QHYNQSEQMNHISDILNVAFTIIFTLEMILKLMAFKARGYFGDPWNVFDFLIVIGSIIDV 1197

1432 ALSDLIQKYFVSPTLF-------------------RVIRLARIGRVLRLIRGAKGIRTLL 1472
      ||++      |  |+                      || |+ |+++|+  |+|+||||
1198 ILSEIDTFLASSGGLYCLGGGCGNVDPDESARISSAFFRLFRVMRLIKLLSRAEGVRTLL 1257

1473 FALMMSLPALFNIGLLLFLVMFIYSIFGMSNFAYVKKESG--IDDMFNFETFGNSIICLF 1530
     +  + |  ||  + ||+ ++ |||++ ||  |  +    |  |+   ||+||  +++ ||
1258 WTFIKSFQALPYVALLIVMLFFIYAVIGMQMFGKIALVDGTQINRNNNFQTFPQAVLLLF 1317

1531 EITTSAGWDGLLNPILNSGPPDCDPNLE-NPGTSVKGDCGNPSIGICFFCSYIIISFLIV 1589
        |   |  +|  +  |    |||  +  ||      ||  +    +| |+ ++   +|
1318 RCATGEAWQEIL--LACSYGKLCDPESDYAPGEEY--TCGT-NFAYYYFISFYMLCAFLV 1372

1590 VNMYIAIILENFNVATEESSEPLGEDDFEMFYETWEKFDPDATQFIAYSRLSDFVDTLQE 1649
     +|+++|+|++||+  | + |  ||    + |   | ++||+|   | +  +   +  +| 
1373 INLFVAVIMDNFDYLTRDWS-ILGPHHLDEFKAIWAEYDPEAKGRIKHLDVVTLLRRIQP 1431

1650 PLRIAK--PNKI---KLITLDLPMVPGDKIHCLDILFALTKEVLGDSGEMDALKQTMEEK 1704
     ||   |  |+++   +|+ +++|+     +     |||| +          |||   |  
1432 PLGFGKFCPHRVACKRLVGMNMPLNSDGTVTFNATLFALVR---------TALKIKTEGN 1482

1705 FMAAN 1709
     |  ||
1483 FEQAN 1487