Alignment between ABCA8 (top ENST00000586539.6 1621aa) and ABCA1 (bottom ENST00000374736.8 2261aa) score 23123

0164 DVYCEVSVFWKEGFVALQAAINAAIIEITTNHSVMEELMSVTGKNMKMHSFIGQSGV--- 0220
     | + ++   |  ||  ||  +  ||| + |     |+   |  + |    ++    +   
0581 DPFEDMRYVW-GGFAYLQDVVEQAIIRVLTG---TEKKTGVYMQQMPYPCYVDDIFLRVM 0636

0221 -------ITDLYLFSCIISFSSFIYYASVNVTRERKRMKALMTMMGLRDSAFWLSWGLLY 0273
            +|  +++|  +     +|        +  |+|  | +||| +|  | || +  
0637 SRSMPLFMTLAWIYSVAVIIKGIVY-------EKEARLKETMRIMGLDNSILWFSWFISS 0689

0274 AGFIFIMALFLALVIRSTQFIILSGFMVVFSLFLLYGLSLVALAFLMSILVKKSFLT--- 0330
        + + |  | ++++    +  |   |||    ++ +  +   ||+| |  ++ |    
0690 LIPLLVSAGLLVVILKLGNLLPYSDPSVVFVFLSVFAVVTILQCFLISTLFSRANLAAAC 0749

0331 -GLVVF------LLTVFW-GCLGFTSLYRHLPASLEWILSLLSPFAFMLGM-------AQ 0375
      |++ |      +| | |   +|||         |+   ||||| ||  |         |
0750 GGIIYFTLYLPYVLCVAWQDYVGFT---------LKIFASLLSPVAFGFGCEYFALFEEQ 0800

0376 LLHLDYDLNSNAFPHP--SDGSNLIVATNFMLAFDTCLYLALAIYFEKILPNEYGHRRPP 0433
      + + +|   | |  |   || ||  + + || ||| ||  +  | | + | +||  || 
0801 GIGVQWD---NLFESPVEEDGFNLTTSVSMML-FDTFLYGVMTWYIEAVFPGQYGIPRPW 0856

0434 LFFLKSSFW--SQTQKTDHVALEDEMDADPSFHDSFEQAPPEFQGKEAIRIRNVTKEYKG 0491
      |    |+|   ++ +  |     +  ++       |+ |     |  + |+|+ | |+ 
0857 YFPCTKSYWFGEESDEKSHPGSNQKRISE----ICMEEEPTHL--KLGVSIQNLVKVYR- 0909

0492 KPDKIE-ALKDLVFDIYEGQITAILGHSGAGKSTLLNILSGLSVPTKGSVTIYNNKL-SE 0549
       | ++ |+  |  + ||||||+ |||+||||+| ++||+||  || |+  |    + ||
0910 --DGMKVAVDGLALNFYEGQITSFLGHNGAGKTTTMSILTGLFPPTSGTAYILGKDIRSE 0967

0550 MADL-ENLSKLTGVCPQSNVQFDFLTVRENLRLFAKIKGILPQEVDKEIQRVLLE--LEM 0606
     |+ + +||    ||||| || || ||| |++  +|++||+  + |  |++++ |+  |  
0968 MSTIRQNL----GVCPQHNVLFDMLTVEEHIWFYARLKGLSEKHVKAEMEQMALDVGLPS 1023

0607 KNIQDVLAQNLSGGQKRKLTFGIAILGDPQIFLLDEPTAGLDPFSRHQVWNLLKERKTDR 0666
       ++   +| |||| +|||+  +| +|  ++ +|||||||+||+||  +| || + +  |
1024 SKLKSKTSQ-LSGGMQRKLSVALAFVGGSKVVILDEPTAGVDPYSRRGIWELLLKYRQGR 1082

0667 VILFSTQFMDEADILADRKVFLSQGKLKCAGSSLFLKKKWGIGYHLSLQLNEI------C 0720
      |+ ||  |||||+| ||   +| ||| | ||||||| + | ||+|+|   ++      |
1083 TIILSTHHMDEADVLGDRIAIISHGKLCCVGSSLFLKNQLGTGYYLTLVKKDVESSLSSC 1142

0721 VEEN------------------------------------ITSLVKQHIPDAKLSAKSEG 0744
        +                                    |++|+++|+ +|+|      
1143 RNSSSTVSYLKKEDSVSQSSSDAGLGSDHESDTLTIDVSAISNLIRKHVSEARLVEDIGH 1202

0745 KLIYTLPLE--RTNKFPELYKDLDS-YPDLGIENYGVSMTTLNEVFLKLEGKSTIN--ES 0799
     +| | || |  +   | ||+ ++|    |||| +||+| ||| |+|||+  +| ++   |
1203 ELTYVLPYEAAKEGAFVELFHEIDDRLSDLGISSYGISETTLEEIFLKVAEESGVDAETS 1262

0800 DIAI--------LGEVQA--------EKADDTERLVEME----QVLSSLN-KMRKTIGGV 0838
     |  +         |+ |+        + ||  +  ++ |     +|| ++ |    + | 
1263 DGTLPARRNRRAFGDKQSCLRPFTEDDAADPNDSDIDPESRETDLLSGMDGKGSYQVKGW 1322

0839 ALWRQQICAIARVRLLKLKHERKALLALLLILMAGFCPLLVEYTMVKIYQNSYTWELSPH 0898
      | +||  |+   |||  +  ||   | +++     |  ||   +|  +    + || | 
1323 KLTQQQFVALLWKRLLIARRSRKGFFAQIVLPAVFVCIALVFSLIVPPFGKYPSLELQPW 1382

0899 LY-----FLA-------------------PG----------------------------- 0905
     +|     |++                   ||                             
1383 MYNEQYTFVSNDAPEDTGTLELLNALTKDPGFGTRCMEGNPIPDTPCQAGEEEWTTAPVP 1442

0906 --------------QQP-------HDPLTQLLIINKTGA----------SIDDFIQSVEH 0934
                   | |        | + ++| +   ||          +  | +| +  
1443 QTIMDLFQNGNWTMQNPSPACQCSSDKIKKMLPVCPPGAGGLPPPQRKQNTADILQDLTG 1502

0935 QNIA-------LEVDAFGTRN--GTDDPSYNGAITVCCN-----------------EKNY 0968
     +||+       +++ |   +|    ++  | |      |                 +|+ 
1503 RNISDYLVKTYVQIIAKSLKNKIWVNEFRYGGFSLGVSNTQALPPSQEVNDAIKQMKKHL 1562

0969 SFSLACNAKR----LNCFPVLMDIVSNGLLGMVKPSVHIRTERSTFLENG--------QD 1016
       +   +| |    |  |   +|  +|  +       |  +     + |          +
1563 KLAKDSSADRFLNSLGRFMTGLDTKNNVKVWFNNKGWHAISSFLNVINNAILRANLQKGE 1622

1017 NPIGF---------------LAYIMFWL----VLTSSC--------PPYIAMSSIDDYKN 1049
     ||  +               |+ +        || | |        |    +  | +  +
1623 NPSHYGITAFNHPLNLTKQQLSEVALMTTSVDVLVSICVIFAMSFVPASFVVFLIQERVS 1682

1050 RARSQLRISGLSPSAYWFGQALVDV-------SLYFLVFVFIYLMSYISNFEDMLLTIIH 1102
     +|+    |||+ |  ||    + |+       +|  ++|+     ||+|+    +| ++ 
1683 KAKHLQFISGVKPVIYWLSNFVWDMCNYVVPATLVIIIFICFQQKSYVSSTNLPVLALLL 1742

1103 IIQIPCAVGYSFSLIFMTYVISFIFRKGRKNSGIWSFCFYVVTVF--------SVAGFAF 1154
     ++       | +|+  + |  ||+|+       | |  + |+|          ||| |  
1743 LL-------YGWSITPLMYPASFVFK-------IPSTAYVVLTSVNLFIGINGSVATFVL 1788

1155 SIFE----SDIPFIF--TFLIPPATMIG---CLFLSSHLLFSSL--FSEERM------DV 1197
      +|     ++|  |    ||| |   +|      + +  +  +|  | | |       |+
1789 ELFTDNKLNNINDILKSVFLIFPHFCLGRGLIDMVKNQAMADALERFGENRFVSPLSWDL 1848

1198 QPFLVFLIPFLHFIIFLFTLRCLEWKFGKKSMRKDPFFRISPRSSDVCQNPEEPEGEDED 1257
         +| +     + || |+  ++++|         | |  ||  +   +|     ||||
1849 VGRNLFAMAVEGVVFFLITV-LIQYRF---------FIR--PRPVNAKLSP--LNDEDED 1894

1258 VQMERVRTANALNSTNFDEKPVIIASCLRKEYAGKRKGCFSKRKNKIATRNVSFCVRKGE 1317
     |+ || |  +        +  ++    | | |         +|| | |   +   +  ||
1895 VRRERQRILD-----GGGQNDILEIKELTKIY---------RRKRKPAVDRICVGIPPGE 1940

1318 VLGLLGHNGAGKSTSIKVITGDTKPTAGQVLLKG----SGGGDALEFLGYCPQENALWPN 1373
       |||| ||||||++ |++||||  | |   |      |   +  + +||||| +|+   
1941 CFGLLGVNGAGKSSTFKMLTGDTTVTRGDAFLNKNSILSNIHEVHQNMGYCPQFDAITEL 2000

1374 LTVRQHLEVYAAVKGLRKGDAEVAITRLVDALKLQDQLKSPVKTLSEGIKRKLCFVLSIL 1433
     || |+|+| +| ++|+ + +        +  | |    +      | | ||||   ++++
2001 LTGREHVEFFALLRGVPEKEVGKVGEWAIRKLGLVKYGEKYAGNYSGGNKRKLSTAMALI 2060

1434 GNPSVVLLDEPSTGMDPEGQQQMWQAIRATFRNTERGALLTTHYMAEAEAVCDRVAIMVS 1493
     | | || ||||+|||||+ ++ +|    +  +   |  +||+| | | ||+| |+||||+
2061 GGPPVVFLDEPTTGMDPKARRFLWNCALSVVKE-GRSVVLTSHSMEECEALCTRMAIMVN 2119

1494 GRLRCIGSIQHLKSKFGKDYLLEMKVK-NLAQVEPLHAEILRLFPQAARQERYSSLMVYK 1552
     || ||+||+||||++||  | + +++  +   ++|+       || +  +|++ +++ |+
2120 GRFRCLGSVQHLKNRFGDGYTIVVRIAGSNPDLKPVQDFFGLAFPGSVLKEKHRNMLQYQ 2179

1553 LPVEDVQPLAQAFFKLEKVKQSFDLEEYSLSQSTLEQVFLELSKEQELGDFEED 1606
     ||   +  ||+ |  | + |+   +|+||+||+||+|||+  +|+|   |  +|
2180 LP-SSLSSLARIFSILSQSKKRLHIEDYSVSQTTLDQVFVNFAKDQSDDDHLKD 2232