UCSC C. elegans Gene Sorter

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UCSC C. elegans Gene Sorter

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#	Name	WormBase	BLASTP E-Value	Genome Position	Description
1	aak-2	T01C8.1b	0	chrX 16,799,385	aak-2 encodes one of two C. elegans homologs of the catalytic alpha subunit of AMP-activated protein kinases (AMPKs); in C. elegans, aak-2 functions downstream of stressors and energy level signals, as well as daf-2-mediated insulin signaling, to positively regulate adult lifespan; in addition, genetic analysis with daf-16 mutants indicates that, in regulating lifespan, AAK-2 likely acts in parallel with DAF-16; aak-2 activity is also required for dauer formation of daf-2 mutant animals at high temperature, in a manner that does not appear to be dependent upon the AMP:ATP ratio; in the germline, aak-2 functions downstream of daf-2 and daf-7, and in parallel to par-4 and aak-1, to negatively regulate germline proliferation during dauer development; in vitro, AAK-2 exhibits AMP-enhanced kinase activity against a known AMPK substrate.