UCSC C. elegans Gene Sorter

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UCSC C. elegans Gene Sorter

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#	Name	WormBase	BLASTP E-Value	Genome Position	Description
1	F13E6.5	F13E6.5	2e-177	chrX 10,696,500	contains similarity to Pfam domain PF01569 PAP2 superfamily contains similarity to Interpro domains IPR000326 (Phosphatidic acid phosphatase type 2/haloperoxidase), IPR016118 (Phosphatidic acid phosphatase/chloroperoxidase, N-terminal)
2	T10D4.6	T10D4.6	n/a	chrII 3,121,247	contains similarity to Pfam domain PF02178 AT hook motif contains similarity to Interpro domains IPR010993 (Sterile alpha motif homology), IPR009057 (Homeodomain-like)
3	figl-1	F32D1.1	n/a	chrV 4,343,730	F32D1.1 encodes an homolog of human SPASTIN (OMIM:604277, mutated in spastic paraplegia), FIDGETIN (OMIM:605295, mutated in fidget mice), and FIDGETIN-LIKE-1, and of Drosophila SPASTIN; recombinant F32D1.1 protein has N-ethylmaleimide-sensitive ATPase activity in vitro, which is strongly dependent on the C368 residue immediately C-terminal to its Walker A motif; F32D1.1 is required for persistence of the germline in RNAi assays.
4	Y45F10D.6	Y45F10D.6	n/a	chrIV 13,797,043
5	dcs-1	Y113G7A.9	n/a	chrV 20,084,683	dcs-1 encodes a scavenger mRNA decapping enzyme; dcs-1 exhibits hydrolase activity in vitro, with specificity for 7meGMP in its primary nucleoside monophosphate binding site; dcs-1 is the upstream gene in an operon with fre-1, which encodes an NADPH-dependent flavin reductase; reporter fusions using dcs-1 upstream sequence direct expression throughout the life cycle in neurons and pharyngeal muscle; expression is present in dauer larvae and enhanced by heat shock.
6	srd-72	Y45G12C.9	n/a	chrV 2,533,025	C. elegans SRD-72 protein; contains similarity to Pfam domain PF01461 7TM chemoreceptor contains similarity to Interpro domains IPR001614 (Myelin proteolipid protein PLP), IPR003002 (7TM chemoreceptor, subfamily 1), IPR002016 (Haem peroxidase, plant/fungal/bacterial)
7	tap-1	C44H4.5	n/a	chrX 14,590,650	C. elegans TAP-1 protein; contains similarity to Pfam domain PF00481 Protein phosphatase 2C contains similarity to Interpro domains IPR001932 (Protein phosphatase 2C-related), IPR014045 (Protein phosphatase 2C, N-terminal), IPR015655 (Protein phosphatase 2C)
8	Y45G12B.3	Y45G12B.3	n/a	chrV 2,691,488	contains similarity to Pfam domain PF01266 FAD dependent oxidoreductase contains similarity to Interpro domains IPR006076 (FAD dependent oxidoreductase), IPR000447 (FAD-dependent glycerol-3-phosphate dehydrogenase), IPR016040 (NAD(P)-binding)
9	clh-6	R07B7.1	n/a	chrV 12,061,778	clh-6 encodes a voltage-gated chloride channel orthologous to the human CLCN7 chloride channel (OMIM:602727, which when mutated lead to osteopetrosis); although the precise role of CLH-6 in C. elegans development and/or behavior is not yet known, CLH-6 expression is detected in two GABA-ergic neurons, RMEL and RMER, suggesting that CLH-6 could play a role in membrane excitability and/or GABA packaging; as CLH-6 is also detected in many non-neuronal tissues, such as the gut and body wall muscle, it could also have a broader role in such as processes as transepithelial transport and muscle excitation.
10	Y48E1C.2	Y48E1C.2	n/a	chrII 13,426,646	contains similarity to Pfam domain PF07942 N2227-like protein contains similarity to Interpro domain IPR012901 (N2227-like)
11	C06H5.6	C06H5.6	n/a	chrV 17,884,381	contains similarity to Pfam domains PF00083 (Sugar (and other) transporter) , PF07690 (Major Facilitator Superfamily) contains similarity to Interpro domains IPR007114 (Major facilitator superfamily), IPR011701 (Major facilitator superfamily MFS-1), IPR005828 (General substrate transporter), IPR016196 (MFS general substrate transporter)
12	Y44E3A.4	Y44E3A.4	n/a	chrI 3,325,798	contains similarity to Pfam domains PF07653 (Variant SH3 domain) (2), PF00018 (SH3 domain) (2)contains similarity to Interpro domains IPR000104 (Antifreeze protein, type I), IPR001452 (Src homology-3), IPR000108 (Neutrophil cytosol factor 2), IPR000694 (Proline-rich region), IPR011511 (Variant SH3), IPR003071 (Orphan nuclear receptor, HMR type)
13	ZK154.4	ZK154.4	n/a	chrX 7,779,677
14	F20D6.11	F20D6.11	n/a	chrV 8,197,919	F20D6.11 encodes a putative flavin-adenine dinucleotide (FAD)-binding oxidoreductase orthologous to human AIFM3 (AIFL), and paralogous to WAH-1 and mammalian PDCD8 (AIF; OMIM:300169, mutated in Harlequin mice); F20D6.11 is expressed in pharynx, anal depressor and body wall muscles, the reproductive system (including spermatheca), and unidentified tail cells; given its orthology to AIFM3, F20D6.11 may promote apoptosis; however, F20D6.11 has no obvious function in mass RNAi assays.
15	F53F1.3	F53F1.3	n/a	chrV 13,409,019	contains similarity to Pfam domain PF00248 Aldo/keto reductase family contains similarity to Interpro domain IPR001395 (Aldo/keto reductase)
16	R02E12.4	R02E12.4	n/a	chrX 4,005,562	contains similarity to Pfam domains PF03148 (Tektin family) , PF00097 (Zinc finger, C3HC4 type (RING finger)) contains similarity to Interpro domains IPR001841 (Zinc finger, RING-type), IPR000435 (Tektin), IPR013083 (Zinc finger, RING/FYVE/PHD-type)
17	T26E4.5	T26E4.5	n/a	chrV 15,787,827	contains similarity to Interpro domain IPR008996 ()
18	vhl-1	F08G12.4	n/a	chrX 11,307,692	vhl-1 is orthologous to the mammalian tumor suppressor gene Von Hippel-Landau syndrome (VHL; OMIM:193300), which is part of a ubiquitylation complex targetting proteins for proteasomal degradation.
19	Y43F4B.7	Y43F4B.7	n/a	chrIII 13,310,326	contains similarity to Pfam domain PF01490 Transmembrane amino acid transporter protein contains similarity to Interpro domains IPR013057 (Amino acid transporter, transmembrane), IPR003568 (Cytochrome c-type biogenesis protein CcmF)
20	W04B5.4	W04B5.4	n/a	chrIII 2,408,633	W04B5.4 encodes a putative mitochondrial ribosomal protein L30 that inhibits DHC-1 in vivo; W04B5.4 is orthologous to human MRPL3; W04B5.4(RNAi) suppresses the lethality of conditional dhc-1 mutations, as well as the spindle length and cytokinesis defects of dhc-1(or195), indicating that W04B5.4 negatively regulates dynein; W04B5.4 is required for embryonic and larval development in mass RNAi assays.
21	F53G12.3	F53G12.3	n/a	chrI 141,205	F53G12.3 encodes a large partial homolog of dual oxidase ('Ce-Duox2'), with an N-terminal peroxidase domain, two central calmodulin-binding EF hands, and a C-terminal superoxide-generating NADPH-oxidase domain; F53G12.3 may be required for dityrosine cross-linking of collagen, and thus for cuticular integrity; F53G12.3 may use cytosolic NADPH to generate reactive oxygen, which then may drive the peroxidase ectodomain to cross-link free tyrosine in collagen; F53G12.3 has no visible expression pattern detectable by antibodies, implying very low or rare expression.
22	F44E2.3	F44E2.3	n/a	chrIII 8,828,256	contains similarity to Interpro domain IPR000694 (Proline-rich region)
23	ubc-20	F40G9.3	n/a	chrIII 189,890	C. elegans UBC-20 protein; contains similarity to Pfam domain PF00179 Ubiquitin-conjugating enzyme contains similarity to Interpro domains IPR000608 (Ubiquitin-conjugating enzyme, E2), IPR009060 (UBA-like), IPR016135 (Ubiquitin-conjugating enzyme/RWD-like), IPR015940 (Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)
24	F34H10.2	F34H10.2	n/a	chrX 9,630,584	contains similarity to Anabaena sp Hypothetical protein Alr0331.; TR:Q8YZX4
25	C35B1.2	C35B1.2	n/a	chrIV 4,094,546	n/a
26	cacn-1	W03H9.4	n/a	chrII 14,137,700	cacn-1 encodes an ortholog of Drosophila CACTIN and human C19orf29 that is required for normal distal tip cell migration, embryonic viability, fertility, locomotion, vulval morphogenesis, and normally rapid growth; like CACTIN, CACN-1 contains predicted coiled-coil domains, but otherwise lacks recognizable similarity to known proteins.
27	pbo-4	K09C8.1	n/a	chrX 10,956,107	pbo-4 encodes a sodium/proton exchanger (also known as nhx-7), with a potential Ca[2+]/calmodulin binding domain in its C-terminal cytosolic region that could mediate calcium signaling; PBO-4 is expressed in the basolateral membrane of posterior intestinal cells; PBO-4 is required for normal posterior body muscle contraction (pBoc) during the defecation cycle; PBO-4 is thought to prevent intracellular acidification by catalysing the electroneutral exchange of extracellular sodium for an intracellular proton; specifically, PBO-4 may enable intercellular signals from intestinal cells (by secreting protons which then might activate PBO-5 in adjacent muscle cells).
28	fbxa-84	T09F5.11	n/a	chrV 15,183,260	This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; this gene's encoded protein also contains an FTH/DUF38 motif, which may also mediate protein-protein interaction.
29	pqn-27	E01G4.4	n/a	chrII 13,454,655	The protein product of this gene is predicted to contain a glutamine/asparagine (Q/N)-rich ('prion') domain, by the algorithm of Michelitsch and Weissman (as of the WS77 release of WormBase, i.e., in wormpep77).
30	T10F2.4	T10F2.4	n/a	chrIII 5,171,158	contains similarity to Pfam domains PF08606 (Prp19/Pso4-like) , PF00400 (WD domain, G-beta repeat) (6)contains similarity to Interpro domains IPR003613 (U box), IPR011046 (WD40 repeat-like), IPR013083 (Zinc finger, RING/FYVE/PHD-type), IPR009053 (Prefoldin), IPR001680 (WD40 repeat), IPR013915 (Pre-mRNA-splicing factor 19), IPR011042 (Six-bladed beta-propeller, TolB-like), IPR015943 (WD40/YVTN repeat-like)
31	W04A8.2	W04A8.2	n/a	chrI 13,840,793	contains similarity to Streptococcus pyogenes Putative type I site-specific deoxyribonuclease hsdS subunit.; TR:Q8K5V9
32	F09E10.5	F09E10.5	n/a	chrX 1,492,033
33	C11D9.1	C11D9.1	n/a	chrI 4,424,085	contains similarity to Pfam domain PF00621 RhoGEF domain contains similarity to Interpro domains IPR000219 (Dbl homology (DH) domain), IPR001478 (PDZ/DHR/GLGF)
34	C18B12.6	C18B12.6	n/a	chrX 15,005,608	contains similarity to Pfam domain PF07970 Protein of unknown function (DUF1692) contains similarity to Interpro domain IPR012936 (Protein of unknown function DUF1692)
35	C36B1.9	C36B1.9	n/a	chrI 8,745,380	contains similarity to Pfam domain PF00097 Zinc finger, C3HC4 type (RING finger) contains similarity to Interpro domains IPR001841 (Zinc finger, RING-type), IPR003604 (Zinc finger, U1-type), IPR013083 (Zinc finger, RING/FYVE/PHD-type), IPR000568 (ATPase, F0 complex, subunit A)
36	Y51H1A.2	Y51H1A.2	n/a	chrII 13,867,372	contains similarity to Pfam domain PF02759 RUN domain contains similarity to Interpro domain IPR004012 (RUN)
37	C06E1.3	C06E1.3	n/a	chrIII 8,582,414	contains similarity to Drosophila melanogaster Flybase gene name is mol-PD;; FLYBASE:CG4482
38	ZK185.2	ZK185.2	n/a	chrIV 4,539,155	ZK185.2 encodes an ortholog of human SLC41A1 (OMIM:610801) and bacterial MgtE; like its orthologs, ZK185.2 is predicted to transport Mg(2+) into cells; ZK185.2 is paralogous to K07H8.2 and ZK1053.6, and has no obvious function in mass RNAi assays.
39	F28B1.3	F28B1.3	n/a	chrV 17,053,645	contains similarity to Interpro domain IPR009021 ()
40	F53H1.3	F53H1.3	n/a	chrIV 1,334,268	contains similarity to Pfam domain PF07792 Protein of unknown function (DUF1630) contains similarity to Interpro domain IPR012860 (Protein of unknown function DUF1630)
41	F56D2.3	F56D2.3	n/a	chrIII 5,585,825
42	taf-2	Y37E11B.4	n/a	chrIV 3,588,951	taf-2 encodes a member of the peptidase M1 family, a predicted aminopeptidase with similarity to human TBP-associated factor 2.
43	C04C3.3	C04C3.3	n/a	chrIV 3,401,683	contains similarity to Pfam domains PF02780 (Transketolase, C-terminal domain) , PF02779 (Transketolase, pyrimidine binding domain) contains similarity to Interpro domains IPR005476 (Transketolase, C-terminal), IPR005475 (Transketolase, central region), IPR015941 (Transketolase C-terminal-like)
44	C25G6.5	C25G6.5	n/a	chrX 1,253,316	contains similarity to Pfam domain PF00001 7 transmembrane receptor (rhodopsin family) contains similarity to Interpro domains IPR017452 (GPCR, rhodopsin-like superfamily), IPR002232 (5-Hydroxytryptamine 6 receptor), IPR000611 (Neuropeptide Y receptor), IPR000276 (GPCR, rhodopsin-like)
45	ZK596.3	ZK596.3	n/a	chrIV 10,903,190	contains similarity to Mus musculus DNA-dependent protein kinase catalytic subunit (EC 2.7.1.37) (DNA-sPKcs) (P460).; SW:PRKD_MOUSE
46	dapk-1	K12C11.4	n/a	chrI 1,316,902	C. elegans DAPK-1 protein; contains similarity to Pfam domains PF00531 (Death domain) , PF00069 (Protein kinase domain) , PF00023 (Ankyrin repeat) (8)contains similarity to Interpro domains IPR017441 (Protein kinase ATP binding, conserved site), IPR002290 (Serine/threonine protein kinase), IPR011029 (DEATH-like), IPR011009 (Protein kinase-like), IPR008271 (Serine/threonine protein kinase, active site), IPR000719 (Protein kinase, core), IPR002110 (Ankyrin), IPR001245 (Tyrosine protein kinase), IPR017442 (Serine/threonine protein kinase-related), IPR000488 (Death)
47	F18A12.7	F18A12.7	n/a	chrII 3,412,942	contains similarity to Pfam domain PF07735 F-box associated contains similarity to Interpro domain IPR012885 (F-box associated type 2)
48	cif-1	K08F11.3	n/a	chrIV 4,708,690	C. elegans CIF-1 protein; contains similarity to Pfam domain PF01399 PCI domain contains similarity to Interpro domain IPR000717 (Proteasome component region PCI)
49	glt-7	W03G1.1	n/a	chrIV 533,911	C. elegans GLT-7 protein; contains similarity to Pfam domain PF00375 Sodium:dicarboxylate symporter family contains similarity to Interpro domain IPR001991 (Sodium:dicarboxylate symporter)
50	K09C4.5	K09C4.5	n/a	chrX 3,284,155	contains similarity to Pfam domains PF07690 (Major Facilitator Superfamily) , PF00083 (Sugar (and other) transporter) contains similarity to Interpro domains IPR007114 (Major facilitator superfamily), IPR011701 (Major facilitator superfamily MFS-1), IPR005828 (General substrate transporter), IPR016196 (MFS general substrate transporter)