UCSC C. elegans Gene Sorter

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UCSC C. elegans Gene Sorter

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#	Name	WormBase	BLASTP E-Value	Genome Position	Description
1	F12F6.8	F12F6.8	0	chrIV 11,556,346	contains similarity to Schizosaccharomyces pombe Adenylate cyclase (EC 4.6.1.1) (ATP pyrophosphate-lyase) (Adenylylscyclase).; SW:CYAA_SCHPO
2	T26E4.5	T26E4.5	n/a	chrV 15,787,827	contains similarity to Interpro domain IPR008996 ()
3	Y53C12B.6	Y53C12B.6	n/a	chrII 9,723,099	contains similarity to Pfam domain PF00100 Zona pellucida-like domain contains similarity to Interpro domain IPR001507 (Endoglin/CD105 antigen)
4	C18A3.2	C18A3.2	n/a	chrII 5,719,035	contains similarity to Pfam domain PF02535 ZIP Zinc transporter contains similarity to Interpro domain IPR003689 (Zinc/iron permease)
5	C41H7.4	C41H7.4	n/a	chrII 3,004,748	contains similarity to Pfam domain PF03353 DUF278 contains similarity to Interpro domain IPR005020 (Protein of unknown function DUF278)
6	T10C6.5	T10C6.5	n/a	chrV 16,023,741	contains similarity to Pfam domain PF04889 Cwf15/Cwc15 cell cycle control protein contains similarity to Interpro domain IPR006973 (Cwf15/Cwc15 cell cycle control protein)
7	rpb-4	F43E2.2	n/a	chrII 7,374,771	C. elegans RPB-4 protein; contains similarity to Pfam domain PF03874 RNA polymerase Rpb4 contains similarity to Interpro domains IPR010997 (HRDC-like), IPR005574 (RNA polymerase II, Rpb4), IPR006590 (RNA polymerase II, Rpb4, core)
8	F23F1.5	F23F1.5	n/a	chrII 30,845	contains similarity to Interpro domains IPR012310 (ATP dependent DNA ligase, central), IPR017336 (Snurportin-1), IPR002652 (Importin-alpha-like, importin-beta-binding region)
9	F41G3.2	F41G3.2	n/a	chrII 6,759,863
10	F56D2.3	F56D2.3	n/a	chrIII 5,585,825
11	F53G12.3	F53G12.3	n/a	chrI 141,205	F53G12.3 encodes a large partial homolog of dual oxidase ('Ce-Duox2'), with an N-terminal peroxidase domain, two central calmodulin-binding EF hands, and a C-terminal superoxide-generating NADPH-oxidase domain; F53G12.3 may be required for dityrosine cross-linking of collagen, and thus for cuticular integrity; F53G12.3 may use cytosolic NADPH to generate reactive oxygen, which then may drive the peroxidase ectodomain to cross-link free tyrosine in collagen; F53G12.3 has no visible expression pattern detectable by antibodies, implying very low or rare expression.
12	mdt-29	K08E3.8	n/a	chrIII 13,776,056	mdt-29 encodes a putative mediator subunit with a prion-like (asparagine- or glutamine-rich) domain; note that K08E3.8 is allegedly an ortholog of Drosophila INTERSEX/IX, but the actual C. elegans IX ortholog appears to be PQN-15); in yeast two-hybrid screens, MDT-29 interacts with SEL-7 and SEL-8; MDT-29 protein also self-associates; RNAi of K08E3.8 weakly enhances the two-anchor-cell phenotype of lin-12(ar170), roughly as much as sel-7 RNAi; since SEL-7 is a novel nuclear protein, MDT-29/SEL-7/SEL-8 is likely to form a nuclear complex formed in response to LIN-12 activation.
13	F36D1.1	F36D1.1	n/a	chrI 11,278,248	contains similarity to Interpro domain IPR006578 (MADF)
14	gpn-1	F59D12.4	n/a	chrX 15,684,484	gpn-1 encodes a glypican, a heparan sulfate proteoglycan anchored to the cell membrane by a GPI linkage, that is orthologous to Drosophila Dally-like (Dlp) and mammalian glypicans (OMIM:312870, mutated in Simpson-Golabi-Behmel overgrowth syndrome); by homology, GPN-1 is predicted to function as a cell surface protein that regulates intercellular signaling, perhaps within the context of cell division and growth regulation; however, as loss of gpn-1 activity via large-scale RNAi screens does not result in any obvious abnormalities, the precise role of GPN-1 in C. elegans development and/or behavior is not yet known.
15	dpm-1	Y66H1A.2	n/a	chrIV 447,058	dpm-1 encodes a putative catalytic subunit of dolichol phosphate mannosyltransferase, orthologous to budding yeast and human DPM1 (OMIM:603503, mutated in congenital disorder of glycosylation type Ie); in mass RNAi assays, DPM-1 is required for embryonic viability and proper cortical motion in the early embryo.
16	M199.2	M199.2	n/a	chrIV 15,109,806	contains similarity to Pfam domain PF00635 MSP (Major sperm protein) domain contains similarity to Interpro domains IPR008962 (PapD-like), IPR000535 (Major sperm protein)
17	pqn-27	E01G4.4	n/a	chrII 13,454,655	The protein product of this gene is predicted to contain a glutamine/asparagine (Q/N)-rich ('prion') domain, by the algorithm of Michelitsch and Weissman (as of the WS77 release of WormBase, i.e., in wormpep77).
18	mrt-2	Y41C4A.14	n/a	chrIII 11,748,489	mrt-2 encodes a highly conserved DNA-damage checkpoint protein homologous to the RAD1 protein found in S. pombe, Drosophila, and mammals; MRT-2 interacts with HUS-1 and HPR-9, also conserved DNA-damage checkpoint proteins, and is required in the germline for maintaining chromosomal integrity; mrt-2 mutations result in a failure to induce apoptosis in response to DNA damage, progressive telomere loss, chromosome fusion, and aneuploidy, all leading eventually to germline immortality.
19	taf-4	R119.6	n/a	chrI 385,688	taf-4 encodes a TAFII (TBP(TATA-binding protein)-associated factor) that is orthologous to human TAF4 (hTAFII130); TAF-4 is predicted to be a component of the TFIID mRNA transcription complex and is generally required for early embryonic mRNA transcription; consistent with this observation, taf-4(RNAi) results in embryonic lethality at the ~100-cell stage with little cell differentiation, similar to the loss of AMA-1/RNA polymerase II activity; TAF-4 is detected in nuclei in the adult germline, oocytes, and embryo, from the 2-cell stage through early morphogenesis.
20	C49D10.10	C49D10.10	n/a	chrII 3,875,377	C49D10.10 encodes a neprilysin; neprilysins are thermolysin-like zinc metallopeptidases, found on the outer surface of animal cells, that negatively regulate small signalling peptides (e.g., enkephalin, tachykinin, insulin, and natriuretic peptides) by cleaving them; C49D10.10 has no clear orthologs in other organisms.
21	chw-1	F22E12.2	n/a	chrV 10,463,355	C. elegans CHW-1 protein; contains similarity to Pfam domains PF00071 (Ras family) , PF08477 (Miro-like protein) contains similarity to Interpro domains IPR002041 (Ran GTPase), IPR003577 (Ras small GTPase, Ras type), IPR013684 (Miro-like), IPR003578 (Ras small GTPase, Rho type), IPR005225 (Small GTP-binding protein), IPR001806 (Ras GTPase), IPR003579 (Ras small GTPase, Rab type), IPR013753 (Ras)
22	srt-15	C50H11.10	n/a	chrV 3,060,908	C. elegans SRT-15 protein; contains similarity to Pfam domain PF01748 Caenorhabditis serpentine receptor-like protein contains similarity to Interpro domain IPR002651 (Protein of unknown function DUF32)
23	T23E1.2	T23E1.2	n/a	chrIV 3,144,252
24	C24D10.4	C24D10.4	n/a	chrIV 5,160,919
25	C11D9.1	C11D9.1	n/a	chrI 4,424,085	contains similarity to Pfam domain PF00621 RhoGEF domain contains similarity to Interpro domains IPR000219 (Dbl homology (DH) domain), IPR001478 (PDZ/DHR/GLGF)
26	C07E3.6	C07E3.6	n/a	chrII 10,368,675	contains similarity to Pfam domain PF00046 Homeobox domain contains similarity to Interpro domains IPR012287 (Homeodomain-related), IPR001356 (Homeobox), IPR009057 (Homeodomain-like)
27	srz-90	C18D4.9	n/a	chrV 17,528,936	C. elegans SRZ-90 protein
28	thoc-1	T02H6.2	n/a	chrII 705,367	C. elegans THOC-1 protein ; contains similarity to Danio rerio THO complex 1.; TR:Q7SYB2
29	K02F3.2	K02F3.2	n/a	chrIII 848,051	The K02F3.2 gene encodes a homolog of human SLC25A13, which when mutated leads to adult onset type II citrullinaemia (OMIM:603471).
30	T22C1.6	T22C1.6	n/a	chrI 7,944,147	contains similarity to Homo sapiens Alpha-taxilin; ENSEMBL:ENSP00000362711
31	T27A3.2	T27A3.2	n/a	chrI 6,112,337	contains similarity to Pfam domains PF00443 (Ubiquitin carboxyl-terminal hydrolase) , PF00627 (UBA/TS-N domain) (2), PF02148 (Zn-finger in ubiquitin-hydrolases and other protein) contains similarity to Interpro domains IPR001394 (Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2), IPR016652 (Ubiquitinyl hydrolase), IPR005924 (Arginase), IPR000449 (Ubiquitin-associated/translation elongation factor EF1B, N-terminal), IPR001607 (Zinc finger, UBP-type), IPR015940 (Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)
32	T22B11.2	T22B11.2	n/a	chrIV 4,690,180	contains similarity to Pfam domain PF01762 Galactosyltransferase contains similarity to Interpro domain IPR002659 (Glycosyl transferase, family 31)
33	Y44E3A.4	Y44E3A.4	n/a	chrI 3,325,798	contains similarity to Pfam domains PF07653 (Variant SH3 domain) (2), PF00018 (SH3 domain) (2)contains similarity to Interpro domains IPR000104 (Antifreeze protein, type I), IPR001452 (Src homology-3), IPR000108 (Neutrophil cytosol factor 2), IPR000694 (Proline-rich region), IPR011511 (Variant SH3), IPR003071 (Orphan nuclear receptor, HMR type)
34	C18H7.5	C18H7.5	n/a	chrIV 587,001
35	C43H6.7	C43H6.7	n/a	chrX 2,400,426	contains similarity to Pfam domain PF01529 DHHC zinc finger domain contains similarity to Interpro domains IPR001594 (Zinc finger, DHHC-type), IPR016201 (Plexin-like fold)
36	W02B3.6	W02B3.6	n/a	chrIII 690,542	contains similarity to Pfam domain PF01744 GLTT repeat (6 copies) contains similarity to Interpro domain IPR008164 (Repeat of unknown function XGLTT)
37	pax-1	K07C11.1	n/a	chrV 8,225,481	C. elegans PAX-1 protein; contains similarity to Pfam domain PF00292 'Paired box' domain contains similarity to Interpro domains IPR001523 (Paired box protein, N-terminal), IPR011991 (Winged helix repressor DNA-binding), IPR009057 (Homeodomain-like)
38	fbxb-31	M151.5	n/a	chrII 3,638,541	C. elegans FBXB-31 protein; contains similarity to Pfam domains PF07735 (F-box associated) , PF00646 (F-box domain) contains similarity to Interpro domains IPR001810 (Cyclin-like F-box), IPR012885 (F-box associated type 2)
39	T05H4.11	T05H4.11	n/a	chrV 6,425,085
40	C29G2.3	C29G2.3	n/a	chrV 2,581,907
41	K05F6.4	K05F6.4	n/a	chrII 1,544,461	This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; its encoded protein also contains a Pfam-B45 motif of presently unknown function.
42	F09E10.5	F09E10.5	n/a	chrX 1,492,033
43	ZK596.3	ZK596.3	n/a	chrIV 10,903,190	contains similarity to Mus musculus DNA-dependent protein kinase catalytic subunit (EC 2.7.1.37) (DNA-sPKcs) (P460).; SW:PRKD_MOUSE
44	C46A5.2	C46A5.2	n/a	chrIV 7,761,432	contains similarity to Pfam domain PF00858 Amiloride-sensitive sodium channel contains similarity to Interpro domain IPR001873 (Na+ channel, amiloride-sensitive)
45	F41C3.4	F41C3.4	n/a	chrII 4,740,995	contains similarity to Pfam domain PF04178 Got1-like family contains similarity to Interpro domain IPR007305 (Got1-like protein)
46	Y48E1C.2	Y48E1C.2	n/a	chrII 13,426,646	contains similarity to Pfam domain PF07942 N2227-like protein contains similarity to Interpro domain IPR012901 (N2227-like)
47	tra-3	LLC1.1	n/a	chrIV 14,440,241	tra-3 encodes an atypical calpain regulatory protease that lacks calcium-binding EF hand domains; during development, TRA-3 likely promotes female development in XX hermaphrodites by cleaving the membrane-associated TRA-2A protein to generate a TRA-2 peptide likely to have feminizing activity; in addition, TRA-3 is one of several proteases that mediate necrotic cell death during neurodegeneration.
48	C17H11.5	C17H11.5	n/a	chrX 8,183,262
49	dgn-1	T21B6.1	n/a	chrX 10,922,297	C. elegans DGN-1 protein; contains similarity to Interpro domains IPR015919 (Cadherin-like), IPR013783 (Immunoglobulin-like fold), IPR006644 (Dystroglycan-type cadherin-like), IPR003992 (Pertactin virulence factor, N-terminal)
50	F56A6.4	F56A6.4	n/a	chrI 622,086