UCSC C. elegans Gene Sorter

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UCSC C. elegans Gene Sorter

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#	Name	WormBase	BLASTP E-Value	Genome Position	Description
1	mrt-2	Y41C4A.14	2.0000000000000002e-129	chrIII 11,748,489	mrt-2 encodes a highly conserved DNA-damage checkpoint protein homologous to the RAD1 protein found in S. pombe, Drosophila, and mammals; MRT-2 interacts with HUS-1 and HPR-9, also conserved DNA-damage checkpoint proteins, and is required in the germline for maintaining chromosomal integrity; mrt-2 mutations result in a failure to induce apoptosis in response to DNA damage, progressive telomere loss, chromosome fusion, and aneuploidy, all leading eventually to germline immortality.
2	T26E4.5	T26E4.5	n/a	chrV 15,787,827	contains similarity to Interpro domain IPR008996 ()
3	pqn-27	E01G4.4	n/a	chrII 13,454,655	The protein product of this gene is predicted to contain a glutamine/asparagine (Q/N)-rich ('prion') domain, by the algorithm of Michelitsch and Weissman (as of the WS77 release of WormBase, i.e., in wormpep77).
4	K10D11.2	K10D11.2	n/a	chrIV 12,980,447	contains similarity to Pfam domain PF02408 CUB-like domain contains similarity to Interpro domain IPR003366 (CUB-like region)
5	T14B4.2	T14B4.2	n/a	chrII 6,736,402	contains similarity to Pfam domain PF01084 Ribosomal protein S18 contains similarity to Interpro domain IPR001648 (Ribosomal protein S18)
6	C46A5.2	C46A5.2	n/a	chrIV 7,761,432	contains similarity to Pfam domain PF00858 Amiloride-sensitive sodium channel contains similarity to Interpro domain IPR001873 (Na+ channel, amiloride-sensitive)
7	Y51H1A.2	Y51H1A.2	n/a	chrII 13,867,372	contains similarity to Pfam domain PF02759 RUN domain contains similarity to Interpro domain IPR004012 (RUN)
8	rpb-4	F43E2.2	n/a	chrII 7,374,771	C. elegans RPB-4 protein; contains similarity to Pfam domain PF03874 RNA polymerase Rpb4 contains similarity to Interpro domains IPR010997 (HRDC-like), IPR005574 (RNA polymerase II, Rpb4), IPR006590 (RNA polymerase II, Rpb4, core)
9	M142.5	M142.5	n/a	chrIII 10,931,599	contains similarity to Homo sapiens Isoform 1 of Protein LSM12 homolog; ENSEMBL:ENSP00000293406
10	taf-12	Y56A3A.4	n/a	chrIII 11,865,724	taf-12 encodes a homolog of transcription initiation factor TFIID 20/15 kDa subunits (TAFII-20/TAFII-15) with a glutamine/asparagine-rich N-terminal domain and a a TFIID-like C-terminal domain.
11	C11D9.1	C11D9.1	n/a	chrI 4,424,085	contains similarity to Pfam domain PF00621 RhoGEF domain contains similarity to Interpro domains IPR000219 (Dbl homology (DH) domain), IPR001478 (PDZ/DHR/GLGF)
12	fbxa-199	T06E6.3	n/a	chrV 15,398,082	srx-40 encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; this gene's encoded protein also contains an FTH/DUF38 motif, which may also mediate protein-protein interaction.
13	gcy-20	F21H7.9	n/a	chrV 16,251,158	gcy-20 encodes a predicted guanylate cyclase.
14	F56A6.4	F56A6.4	n/a	chrI 622,086
15	thoc-1	T02H6.2	n/a	chrII 705,367	C. elegans THOC-1 protein ; contains similarity to Danio rerio THO complex 1.; TR:Q7SYB2
16	ZC190.7	ZC190.7	n/a	chrV 8,686,461
17	srx-53	T27C5.2	n/a	chrV 17,400,916	C. elegans SRX-53 protein; contains similarity to Interpro domain IPR010989 (t-SNARE)
18	T23E1.2	T23E1.2	n/a	chrIV 3,144,252
19	F53G12.3	F53G12.3	n/a	chrI 141,205	F53G12.3 encodes a large partial homolog of dual oxidase ('Ce-Duox2'), with an N-terminal peroxidase domain, two central calmodulin-binding EF hands, and a C-terminal superoxide-generating NADPH-oxidase domain; F53G12.3 may be required for dityrosine cross-linking of collagen, and thus for cuticular integrity; F53G12.3 may use cytosolic NADPH to generate reactive oxygen, which then may drive the peroxidase ectodomain to cross-link free tyrosine in collagen; F53G12.3 has no visible expression pattern detectable by antibodies, implying very low or rare expression.
20	Y48B6A.1	Y48B6A.1	n/a	chrII 14,152,681	Y48B6A.1 encodes an ortholog of human BOP1 (OMIM:610596, overexpressed in colon cancer) and S. cerevisiae ERB1; Y48B6A.1 may suppress tumorous growth in the germline; like PRO-1, -2, and -3, Y48B6A.1 is probably required for ribosome biogenesis, suggesting a link between biogenesis in the distal sheath and control of cell division in the germline; however, BOP1 is also a phosphoprotein in mitotic spindles and required for normal chromosomal segregation, raising the possibility that Y48B6A.1 is multifunctional.
21	srz-90	C18D4.9	n/a	chrV 17,528,936	C. elegans SRZ-90 protein
22	F41G3.2	F41G3.2	n/a	chrII 6,759,863
23	srt-1	C13B7.1	n/a	chrV 2,436,754	C. elegans SRT-1 protein; contains similarity to Pfam domain PF01748 Caenorhabditis serpentine receptor-like protein contains similarity to Interpro domain IPR002651 (Protein of unknown function DUF32)
24	T26G10.1	T26G10.1	n/a	chrIII 9,405,416	contains similarity to Pfam domains PF00270 (DEAD/DEAH box helicase) , PF00271 (Helicase conserved C-terminal domain) contains similarity to Interpro domains IPR011545 (DNA/RNA helicase, DEAD/DEAH box type, N-terminal), IPR000629 (RNA helicase, ATP-dependent, DEAD-box, conserved site), IPR014021 (Helicase, superfamily 1 and 2, ATP-binding), IPR014014 (RNA helicase, DEAD-box type, Q motif), IPR014001 (DEAD-like helicase, N-terminal), IPR001650 (DNA/RNA helicase, C-terminal)
25	T21B4.3	T21B4.3	n/a	chrII 12,495,897	contains similarity to Pfam domain PF01681 C6 domain contains similarity to Interpro domain IPR002601 (Protein of unknown function C6)
26	F41C3.4	F41C3.4	n/a	chrII 4,740,995	contains similarity to Pfam domain PF04178 Got1-like family contains similarity to Interpro domain IPR007305 (Got1-like protein)
27	srj-32	F07G11.5	n/a	chrV 7,296,979	C. elegans SRJ-32 protein; contains similarity to Pfam domain PF01461 7TM chemoreceptor contains similarity to Interpro domain IPR003002 (7TM chemoreceptor, subfamily 1)
28	T07D3.3	T07D3.3	n/a	chrII 895,627	contains similarity to Homo sapiens CGI16-iso; ENSEMBL:ENSP00000368599
29	F23F1.5	F23F1.5	n/a	chrII 30,845	contains similarity to Interpro domains IPR012310 (ATP dependent DNA ligase, central), IPR017336 (Snurportin-1), IPR002652 (Importin-alpha-like, importin-beta-binding region)
30	vha-1	R10E11.8	n/a	chrIII 9,781,407	vha-1 encodes an ortholog of subunit c of the membrane-bound (V0) domain of vacuolar proton-translocating ATPase (V-ATPase); VHA-1 is a predicted V-ATPase transmembrane rotor component; VHA-1 and VHA-2/3 comprise a closely related family of subunit c co-orthologs, predicted to carry protons from the cytosol to a-subunits (VHA-5, VHA-6, VHA-7, or UNC-32) for transmembrane export; VHA-1, like VHA-12 and VHA-17, antagonizes EFF-1-mediated cell fusion in hypodermal cells; VHA-1 is required for ovulation and embryogenesis, since vha-1(RNAi) animals are sterile with polyploid, unmatured oocytes and dead progeny; VHA-1 is required for alae formation, like the V0 subunits VHA-4 and VHA-5, but not like the V1 subunits VHA-8 or VHA-13; vha-1 shares an operon with vha-2 and R10E11.6; both vha-1 and vha-2 are expressed in the excretory cell, the rectum, and a pair of cells near the anus.
31	C34C6.2	C34C6.2	n/a	chrII 8,681,696	contains similarity to Homo sapiens KIAA1219; ENSEMBL:ENSP00000302059
32	tra-3	LLC1.1	n/a	chrIV 14,440,241	tra-3 encodes an atypical calpain regulatory protease that lacks calcium-binding EF hand domains; during development, TRA-3 likely promotes female development in XX hermaphrodites by cleaving the membrane-associated TRA-2A protein to generate a TRA-2 peptide likely to have feminizing activity; in addition, TRA-3 is one of several proteases that mediate necrotic cell death during neurodegeneration.
33	cdk-8	F39H11.3	n/a	chrI 8,704,132	cdk-8 encodes a member of the cyclin-dependent serine/threonine protein kinase family orthologous to human CDK8 (OMIM:603184) which functions in transcriptional regulation with the positive regulatory factor cyclin C, is associated with the RNA polymerase II holoenzyme, and may regulate gene-specific activators; CDK-8 also contains a glutamine/asparagine-rich domain; loss of cdk-8 function via RNA-mediated interference (RNAi) results in sterility in the injected hermaphrodite, suggesting that in C. elegans, CDK-8 may play a role in germ-line development.
34	T27A3.2	T27A3.2	n/a	chrI 6,112,337	contains similarity to Pfam domains PF00443 (Ubiquitin carboxyl-terminal hydrolase) , PF00627 (UBA/TS-N domain) (2), PF02148 (Zn-finger in ubiquitin-hydrolases and other protein) contains similarity to Interpro domains IPR001394 (Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2), IPR016652 (Ubiquitinyl hydrolase), IPR005924 (Arginase), IPR000449 (Ubiquitin-associated/translation elongation factor EF1B, N-terminal), IPR001607 (Zinc finger, UBP-type), IPR015940 (Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)
35	W07E6.3	W07E6.3	n/a	chrII 496,617	contains similarity to Interpro domain IPR000326 (Phosphatidic acid phosphatase type 2/haloperoxidase)
36	K10C2.6	K10C2.6	n/a	chrX 6,451,568
37	srt-15	C50H11.10	n/a	chrV 3,060,908	C. elegans SRT-15 protein; contains similarity to Pfam domain PF01748 Caenorhabditis serpentine receptor-like protein contains similarity to Interpro domain IPR002651 (Protein of unknown function DUF32)
38	F28B1.3	F28B1.3	n/a	chrV 17,053,645	contains similarity to Interpro domain IPR009021 ()
39	H04M03.1	H04M03.1	n/a	chrIV 5,897,858	contains similarity to Pfam domain PF00821 Phosphoenolpyruvate carboxykinase contains similarity to Interpro domains IPR013035 (Phosphoenolpyruvate carboxykinase, C-terminal), IPR008210 (Phosphoenolpyruvate carboxykinase, N-terminal), IPR008209 (Phosphoenolpyruvate carboxykinase, GTP-utilising)
40	T01C3.2	T01C3.2	n/a	chrV 14,991,380	T01C3.2 encodes a divergent ortholog of Drosophila melanogaster E(Y)2 and budding yeast Sus1p; by orthology, T01C3.2 is predicted to enable both transcriptional activation and silencing in chromatin; however, T01C3.2 has no obvious function in mass RNAi assays.
41	dpm-1	Y66H1A.2	n/a	chrIV 447,058	dpm-1 encodes a putative catalytic subunit of dolichol phosphate mannosyltransferase, orthologous to budding yeast and human DPM1 (OMIM:603503, mutated in congenital disorder of glycosylation type Ie); in mass RNAi assays, DPM-1 is required for embryonic viability and proper cortical motion in the early embryo.
42	ZK185.2	ZK185.2	n/a	chrIV 4,539,155	ZK185.2 encodes an ortholog of human SLC41A1 (OMIM:610801) and bacterial MgtE; like its orthologs, ZK185.2 is predicted to transport Mg(2+) into cells; ZK185.2 is paralogous to K07H8.2 and ZK1053.6, and has no obvious function in mass RNAi assays.
43	K09B11.10	K09B11.10	n/a	chrIV 13,439,731	contains similarity to Interpro domain IPR000998 (MAM)
44	Y18D10A.1	Y18D10A.1	n/a	chrI 12,797,263	contains similarity to Pfam domain PF02178 AT hook motif contains similarity to Interpro domains IPR000116 (High mobility group proteins HMG-I and HMG-Y), IPR000637 (HMG-I and HMG-Y, DNA-binding)
45	H14E04.1	H14E04.1	n/a	chrIII 2,404,160	contains similarity to Pfam domains PF02353 (Cyclopropane-fatty-acyl-phospholipid synthase) , PF08242 (Methyltransferase domain) , PF08241 (Methyltransferase domain) , PF01209 (ubiE/COQ5 methyltransferase family) contains similarity to Interpro domains IPR004033 (UbiE/COQ5 methyltransferase), IPR003333 (Cyclopropane-fatty-acyl-phospholipid synthase), IPR013217 (Methyltransferase type 12), IPR013216 (Methyltransferase type 11)
46	K08F4.5	K08F4.5	n/a	chrIV 10,135,380	contains similarity to Paramecium tetraurelia Chromosome undetermined scaffold_96, whole genome shotgun sequence.; TR:A0EH68
47	T07D1.5	T07D1.5	n/a	chrX 2,419,146
48	F31D5.4	F31D5.4	n/a	chrII 4,179,466	contains similarity to Pfam domain PF01825 Latrophilin/CL-1-like GPS domain contains similarity to Interpro domain IPR000203 (GPS)
49	tag-179	T24D1.4	n/a	chrI 9,961,143	C. elegans TAG-179 protein; contains similarity to Pfam domain PF04922 DIE2/ALG10 family contains similarity to Interpro domains IPR016900 (Alpha-1, 2 glucosyltransferase Alg10), IPR007006 (DIE2/ALG10)
50	F23B2.8	F23B2.8	n/a	chrIV 9,152,242	contains similarity to Interpro domain IPR001478 (PDZ/DHR/GLGF)