UCSC C. elegans Gene Sorter

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UCSC C. elegans Gene Sorter

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#	Name	WormBase	BLASTP E-Value	Genome Position	Description
1	fbxa-45	F09C6.6	4e-177	chrV 16,898,926	This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; this gene's encoded protein also contains an FTH/DUF38 motif, which may also mediate protein-protein interaction.
2	apx-1	K08D9.3	n/a	chrV 3,216,670	apx-1 encodes one of ten C. elegans DSL (Delta, Serrate, LAG-2) proteins, integral transmembrane and secreted proteins that function as signaling ligands for the Notch family receptors GLP-1 and LIN-12; in the 4-cell embryo, maternally supplied APX-1 functions as a GLP-1 ligand for an inductive interaction that specifies the fate of the ABp blastomere; later in embryogenesis, APX-1 is required for formation of the LIN-12-dependent, invariant asymmetrical twist that occurs as part of normal gut morphogenesis; during larval development, APX-1 is required redundantly with DSL-1 and LAG-2 for the LIN-12-mediated lateral signal that spatially patterns the primary and secondary vulval cell lineages; in the early embryo, APX-1 is first detected at the anterior edge of the P1 blastomere, with later expression visible in P2 at sites of contact with ABp, and in the cytoplasm of the EMS and P3 blastomeres; expression in the vulval precursor cells (VPCs) is detected in the primary VPC, P6.p, and its descendants; embryonic APX-1 expression is dependent upon PIE-1 activity, while later vulval expression is mediated by the Ras signaling pathway and the SUR-2 transcriptional cofactor.
3	immp-1	C24H11.6	n/a	chrIII 11,775,731	C. elegans IMMP-1 protein; contains similarity to Pfam domain PF00717 Peptidase S24-like contains similarity to Interpro domains IPR001733 (Peptidase S26B, eukaryotic signal peptidase), IPR015927 (Peptidase S24, S26A, S26B and S26C), IPR014037 (Peptidase S26A), IPR011056 (Peptidase S24, S26A and S26B, C-terminal), IPR000223 (Peptidase S26A, signal peptidase I)
4	srh-136	F36D3.6	n/a	chrV 16,496,767	C. elegans SRH-136 protein; contains similarity to Pfam domain PF01461 7TM chemoreceptor contains similarity to Interpro domain IPR003002 (7TM chemoreceptor, subfamily 1)
5	C03B1.9	C03B1.9	n/a	chrX 6,346,694
6	B0511.5	B0511.5	n/a	chrI 10,630,197	contains similarity to Pfam domain PF00100 Zona pellucida-like domain contains similarity to Interpro domain IPR001507 (Endoglin/CD105 antigen)
7	athp-1	C44B9.4	n/a	chrIII 10,887,899	C. elegans ATHP-1 protein; contains similarity to Pfam domains PF02178 (AT hook motif) (2), PF00628 (PHD-finger) contains similarity to Interpro domains IPR008984 (SMAD/FHA domain), IPR001965 (Zinc finger, PHD-type), IPR000637 (HMG-I and HMG-Y, DNA-binding), IPR013083 (Zinc finger, RING/FYVE/PHD-type), IPR000294 (Vitamin K-dependent carboxylation/gamma-carboxyglutamic region), IPR000253 (Forkhead-associated), IPR011011 (Zinc finger, FYVE/PHD-type)
8	F08B4.3	F08B4.3	n/a	chrIV 8,666,337	contains similarity to Interpro domain IPR000719 (Protein kinase, core)
9	Y45F3A.5	Y45F3A.5	n/a	chrIII 10,585,998	contains similarity to Saccharomyces cerevisiae Protein involved in pre-rRNA processing, 18S rRNA synthesis, and snoRNA synthesis; component of the small subunit processome complex, which is required for processing of pre-18S rRNA; SGD:YOR310C
10	F55F8.3	F55F8.3	n/a	chrI 5,651,700	contains similarity to Pfam domains PF04047 (Periodic tryptophan protein 2 WD repeat associated presumed domain) , PF00400 (WD domain, G-beta repeat) (5)contains similarity to Interpro domains IPR000009 (Protein phosphatase 2A, regulatory subunit PR55), IPR017441 (Protein kinase ATP binding, conserved site), IPR011046 (WD40 repeat-like), IPR007190 (Periodic tryptophan protein-associated region), IPR001680 (WD40 repeat), IPR015943 (WD40/YVTN repeat-like)
11	srh-10	Y38A10A.3	n/a	chrV 6,066,281	C. elegans SRH-10 protein; contains similarity to Pfam domain PF01461 7TM chemoreceptor contains similarity to Interpro domain IPR003002 (7TM chemoreceptor, subfamily 1)
12	F35E2.2	F35E2.2	n/a	chrI 11,737,158	This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins.
13	srh-77	DC2.6	n/a	chrV 224,988	C. elegans SRH-77 protein; contains similarity to Pfam domain PF01461 7TM chemoreceptor contains similarity to Interpro domain IPR003002 (7TM chemoreceptor, subfamily 1)
14	F35F10.14	F35F10.14	n/a	chrV 3,319,580
15	ptr-13	K07C10.1	n/a	chrII 11,159,735	ptr-13 encodes a nematode-specific member of the sterol sensing domain (SSD) proteins, distantly paralogous to Drosophila PATCHED (PTC) and human PTCH (OMIM:601309, mutated in basal cell nevus syndrome); PTR-13 is weakly required for normal molting from L4 to adult stages; PTR-13 is also required for normal growth to full size and locomotion.
16	Y79H2A.4	Y79H2A.4	n/a	chrIII 12,041,576	contains similarity to Interpro domains IPR012677 (Nucleotide-binding, alpha-beta plait), IPR000504 (RNA recognition motif, RNP-1)
17	C09G9.3	C09G9.3	n/a	chrIV 8,871,534	contains similarity to Pfam domain PF01681 C6 domain contains similarity to Interpro domain IPR002601 (Protein of unknown function C6)
18	str-122	W03D2.10	n/a	chrIV 4,067,151	C. elegans STR-122 protein; contains similarity to Pfam domain PF01461 7TM chemoreceptor contains similarity to Interpro domain IPR003002 (7TM chemoreceptor, subfamily 1)
19	grl-1	C24G6.7	n/a	chrV 5,532,342	grl-1 encodes a hedgehog-like protein, with an N-terminal signal sequence, a central proline-rich region, and a C-terminal Ground-like (Grl) domain; GRL-1 is expressed in intestine, neurons, and larval arcade cells; the Grl domain is predicted to form a cysteine-crosslinked protein involved in intercellular signalling, and it has subtle similarity to the N-terminal Hedge domain of HEDGEHOG proteins.
20	W04C9.6	W04C9.6	n/a	chrI 485,237	contains similarity to Pfam domain PF07690 Major Facilitator Superfamily contains similarity to Interpro domains IPR000694 (Proline-rich region), IPR011701 (Major facilitator superfamily MFS-1), IPR016196 (MFS general substrate transporter)
21	cdh-1	R10F2.1	n/a	chrIII 2,923,253	cdh-1 encodes a cadherin that is similar, in the extracellular domain, to the Drosophila cadherin Dachsous (Ds); although the precise role of cdh-1 in C. elegans development and/or behavior is not yet known, loss of cdh-1 activity via RNAi using the hypersensitive rrf-3 strain can result in locomotion and growth defects, as well as larval lethality.
22	tag-236	R11B5.1	n/a	chrX 2,528,819	C. elegans TAG-236 protein; contains similarity to Pfam domain PF00566 TBC domain contains similarity to Interpro domain IPR000195 (RabGAP/TBC)
23	C04E12.5	C04E12.5	n/a	chrV 3,359,866	contains similarity to Pfam domain PF04721 Domain of unknown function (DUF750) contains similarity to Interpro domain IPR006588 (Protein of unknown function PAW)
24	Y116A8C.9	Y116A8C.9	n/a	chrIV 16,943,608	contains similarity to Danio rerio Transmembrane protein 185-like.; SW:Q7SYC7
25	F09E10.6	F09E10.6	n/a	chrX 1,496,339
26	evl-20	F22B5.1	n/a	chrII 8,444,637	evl-20 encodes a functional ortholog of human ADP-ribosylation factor-like protein 2 (ARL2; OMIM:601175), with evl-20(ar103) mutants being rescued by transgenic human ARL2 but not ARL1 or ARL3-7; EVL-20 is required for cortical microtubule formation during cytokinesis and morphogenesis; EVL-20 is required for vulval, gonadal, and male tail development, as well as for embryonic mitosis, hypodermal enclosure, and elongation; EVL-20 is expressed in migrating hypodermal embryonic cells, larval vulval and somatic gonad cells, larval and adult neurons, and adult male proctodeal cells, being subcellularly associated with both the cell cortex and astral microtubules.
27	clec-90	F57C9.2	n/a	chrI 4,846,413	C. elegans CLEC-90 protein; contains similarity to Interpro domains IPR002919 (Protease inhibitor I8, cysteine-rich trypsin inhibitor-like), IPR001304 (C-type lectin)
28	srsx-27	C51E3.2	n/a	chrV 10,151,415	C. elegans SRSX-27 protein; contains similarity to Pfam domain PF00001 7 transmembrane receptor (rhodopsin family) contains similarity to Interpro domains IPR017452 (GPCR, rhodopsin-like superfamily), IPR000276 (GPCR, rhodopsin-like)
29	sru-19	T04A11.8	n/a	chrIV 12,499,445	C. elegans SRU-19 protein; contains similarity to Pfam domain PF02688 Domain of unknown function DUF215 contains similarity to Interpro domain IPR003839 (Protein of unknown function DUF215)
30	clec-245	C31G12.2	n/a	chrV 18,187,150	C. elegans CLEC-245 protein; contains similarity to Pfam domain PF00059 Lectin C-type domain contains similarity to Interpro domains IPR016187 (C-type lectin fold), IPR016186 (C-type lectin-like), IPR001304 (C-type lectin)
31	str-240	K02H11.2	n/a	chrV 1,521,205	C. elegans STR-240 protein; contains similarity to Pfam domain PF01461 7TM chemoreceptor contains similarity to Interpro domain IPR003002 (7TM chemoreceptor, subfamily 1)
32	F07H5.6	F07H5.6	n/a	chrII 8,792,268	contains similarity to Interpro domain IPR002952 (Eggshell protein)
33	E04A4.6	E04A4.6	n/a	chrIV 4,746,804	contains similarity to Homo sapiens Isoform 5 of Tectonic-1 precursor; ENSEMBL:ENSP00000380771
34	T08G5.7	T08G5.7	n/a	chrV 14,044,675	contains similarity to Interpro domains IPR015880 (Zinc finger, C2H2-like), IPR003656 (Zinc finger, BED-type predicted), IPR007087 (Zinc finger, C2H2-type)
35	twk-3	M110.2	n/a	chrII 8,211,638	C. elegans TWK-3 protein; contains similarity to Pfam domain PF07885 Ion channel contains similarity to Interpro domains IPR003280 (Potassium channel, two pore-domain), IPR013099 (Ion transport 2)
36	T26C12.2	T26C12.2	n/a	chrIV 3,264,607	contains similarity to Interpro domain IPR001991 (Sodium:dicarboxylate symporter)
37	his-4	T10C6.11	n/a	chrV 16,040,303	his-4 encodes an H2B histone.
38	B0250.2	B0250.2	n/a	chrV 20,473,310	contains similarity to Drosophila erecta Female-specific transformer protein.; SW:TRSF_DROER
39	C44H4.6	C44H4.6	n/a	chrX 14,597,741	contains similarity to Pfam domain PF00069 Protein kinase domain contains similarity to Interpro domains IPR017441 (Protein kinase ATP binding, conserved site), IPR002290 (Serine/threonine protein kinase), IPR011009 (Protein kinase-like), IPR008271 (Serine/threonine protein kinase, active site), IPR000719 (Protein kinase, core), IPR001245 (Tyrosine protein kinase), IPR017442 (Serine/threonine protein kinase-related)
40	srt-5	C50H11.14	n/a	chrV 3,080,169	C. elegans SRT-5 protein; contains similarity to Pfam domain PF01748 Caenorhabditis serpentine receptor-like protein contains similarity to Interpro domain IPR002651 (Protein of unknown function DUF32)
41	acbp-4	F56C9.5	n/a	chrIII 7,308,549	acbp-4 encodes an Acyl-CoA-binding protein.
42	cdh-8	F18F11.3	n/a	chrIV 351,612	cdh-8 encodes a cadherin that may be nematode specific; CDH-8 is predicted to function as a membrane protein that plays a role in cell adhesion and/or morphogenesis, but as loss of cdh-8 activity via mutation or large-scale RNAi experiments results in no obvious abnormalities, the precise role of cdh-8 in C. elegans development and/or behavior is not yet known.
43	C31E10.1	C31E10.1	n/a	chrX 13,985,013	contains similarity to Pfam domain PF01461 7TM chemoreceptor contains similarity to Interpro domains IPR003002 (7TM chemoreceptor, subfamily 1), IPR000238 (Ribosome-binding factor A)
44	T14G10.8	T14G10.8	n/a	chrIV 10,146,609	contains similarity to Homo sapiens Splice isoform 1 of P08235 Mineralocorticoid receptor; ENSEMBL:ENSP00000281330
45	C03B1.10	C03B1.10	n/a	chrX 6,357,809	contains similarity to Homo sapiens cDNA FLJ42885 fis, clone BRHIP3007586; HI:HIT000044748
46	F54E4.4	F54E4.4	n/a	chrX 14,643,359	contains similarity to Pfam domain PF03931 Skp1 family, tetramerisation domain contains similarity to Interpro domains IPR001232 (SKP1 component), IPR011333 (BTB/POZ fold), IPR016073 (SKP1 component, POZ)
47	clec-11	C54C8.7	n/a	chrI 12,460,190	C. elegans CLEC-11 protein; contains similarity to Pfam domains PF00431 (CUB domain) , PF00059 (Lectin C-type domain) (2)contains similarity to Interpro domains IPR000859 (CUB), IPR016187 (C-type lectin fold), IPR016186 (C-type lectin-like), IPR001304 (C-type lectin)
48	sru-25	F31F4.14	n/a	chrV 673,072	C. elegans SRU-25 protein; contains similarity to Pfam domain PF02688 Domain of unknown function DUF215 contains similarity to Interpro domain IPR003839 (Protein of unknown function DUF215)
49	hpl-1	K08H2.6	n/a	chrX 13,246,140	hpl-1 encodes one of two C. elegans heterochromatin protein 1 (HP1) homologs; loss of hpl-1 activity alone results in no obvious defects, but animals doubly mutant for hpl-1 and hpl-2 have defects in larval, somatic gonad and germline development; in addition, hpl-1 functions redundantly with hpl-2 and lin-13 in vulval development; rescuing HPL-1::GFP fusion proteins are expressed in nuclei throughout the life cycle, beginning at approximately the 50-cell stage of embryogenesis and continuing through larval and adult stages; expression is observed in most, but not all, cells and is particularly strong in head and tail hypodermal and neuronal nuclei; in nuclei, HPL-1::GFP is seen in foci that do not significantly overlap with those of HPL-2.
50	phat-1	C46H11.8	n/a	chrI 5,045,010	C. elegans PHAT-1 protein; contains similarity to Pfam domain PF01549 ShK domain-like contains similarity to Interpro domain IPR003582 (Metridin-like ShK toxin)