UCSC C. elegans Gene Sorter

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UCSC C. elegans Gene Sorter

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#	Name	WormBase	BLASTP E-Value	Genome Position	Description
1	fbxa-10	T12B5.3	3e-175	chrIII 953,160	This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; this gene's encoded protein also contains an FTH/DUF38 motif, which may also mediate protein-protein interaction.
2	T26E4.5	T26E4.5	n/a	chrV 15,787,827	contains similarity to Interpro domain IPR008996 ()
3	pgp-10	C54D1.1	n/a	chrX 7,162,476	pgp-10 encodes an ATP-binding protein that is a member of the P-glycoprotein subclass of the ATP-binding cassette (ABC) transporter superfamily; PGP-10 is predicted to function as a transmembrane protein that couples energy to transport of various molecules across membranes, but as loss of pgp-10 activity via RNAi results in no obvious defects, the exact role of pgp-10 in C. elegans development and/or behavior is not yet known; pgp-10 promoter-gfp fusion proteins are expressed in larvae and adults in the intestine and hypodermis.
4	ZK856.6	ZK856.6	n/a	chrV 10,199,178	contains similarity to Ralstonia solanacearum Composite TWO-component regulatory (Sensor kinase and responsesregulator hybrid) transcription regulator protein.; TR:Q8XWL8
5	kqt-3	Y54G9A.3	n/a	chrII 13,704,530	kqt-3 encodes one of three C. elegans KCNQ-like potassium channel subunits and, with respect to humans, is most similar to the KCNQ1 channel protein which when mutated leads to inherited long QT syndrome (OMIM:607542); although loss of KQT-3 activity via large-scale RNAi screens results in no obvious abnormalities, KQT-3 likely functions to regulate cellular excitability as expression of KQT-3 in Xenopus oocytes can produce K+ channel currents that functionally resemble vertebrate M-currents; activity of these KQT-3 channels can be suppressed by coexpression with the human M1 muscarinic receptor and treatment with diacylglycerol analogs, although KQT-3 is less sensitive to each of these treatments than KQT-1; a KQT-3::GFP fusion protein is expressed in the anterior- and posterior-most intestinal cells, the anterior and posterior mechanosensory neurons ALM and PLM, amphid and phasmid neurons, and in some additional head neurons.
6	F42G8.5	F42G8.5	n/a	chrIV 8,137,753
7	ckr-1	T23B3.4	n/a	chrI 6,688,888	T23B3.4 encodes a seven transmembrane receptor that is most closely related to the mammalian cholecystokinin receptors; loss of T23B3.4 activity via RNAi, either singly or in combination with another cholecystokinin receptor-encoding gene, Y39A3B.5, has no effect on fat metabolism, however large-scale RNAi screens have reported that T23B3.4(RNAi) results in embryonic lethality and reduced brood sizes; a T23B3.4::GFP reporter is expressed in a subset of nerve ring neurons.
8	ser-5	F16D3.7	n/a	chrI 8,385,819	F16D3.7 encodes a homolog of mammalian alpha-adrenergic receptors that is expressed in vulval and bodywall muscle cells, intestine, and head neurons; heterologously expressed F16D3.7 has no effect on adenylate cyclase signalling; F16D3.7 has no obvious function in RNAi assays of brood size, egg laying, pharyngeal pumping, locomotion, or male mating.
9	str-92	F59A1.3	n/a	chrV 17,675,766	C. elegans STR-92 protein; contains similarity to Pfam domain PF01461 7TM chemoreceptor contains similarity to Interpro domain IPR003002 (7TM chemoreceptor, subfamily 1)
10	srx-68	K07C6.11	n/a	chrV 3,913,635	C. elegans SRX-68 protein; contains similarity to Pfam domain PF01748 Caenorhabditis serpentine receptor-like protein contains similarity to Interpro domains IPR017452 (GPCR, rhodopsin-like superfamily), IPR002651 (Protein of unknown function DUF32)
11	C49A9.7	C49A9.7	n/a	chrIV 6,203,875	contains similarity to Pfam domain PF00001 7 transmembrane receptor (rhodopsin family) contains similarity to Interpro domains IPR017452 (GPCR, rhodopsin-like superfamily), IPR001681 (Neurokinin receptor), IPR005395 (Neuropeptide FF receptor), IPR005384 (Duffy antigen/chemokine receptor), IPR000611 (Neuropeptide Y receptor), IPR000276 (GPCR, rhodopsin-like)
12	egl-36	R07A4.1	n/a	chrX 10,739,267	egl-36 encodes a Shaw-type voltage-gated potassium channel that regulates egg laying and defecation; expression of egl-36::gfp reporters is observed in several different cell types including muscle cells such as the uterine and vulval egg-laying muscles, sensory, motor and interneurons, and the distal tip cells of the gonad; when expressed in a heterologous system, EGL-36 exhibits channel activity.
13	Y54E2A.10	Y54E2A.10	n/a	chrII 14,791,729	contains similarity to Dictyostelium discoideum Protein-tyrosine phosphatase 3 (EC 3.1.3.48) (Protein-tyrosine-sphosphate phosphohydrolase 3).; SW:PTP3_DICDI
14	F59B1.6	F59B1.6	n/a	chrV 3,630,559	contains similarity to Pfam domain PF01461 7TM chemoreceptor contains similarity to Interpro domain IPR003002 (7TM chemoreceptor, subfamily 1)
15	srt-14	ZC142.2	n/a	chrV 4,255,024	C. elegans SRT-14 protein; contains similarity to Pfam domain PF01748 Caenorhabditis serpentine receptor-like protein contains similarity to Interpro domain IPR002651 (Protein of unknown function DUF32)
16	F09D1.1	F09D1.1	n/a	chrII 2,570,590	contains similarity to Pfam domains PF00443 (Ubiquitin carboxyl-terminal hydrolase) , PF02148 (Zn-finger in ubiquitin-hydrolases and other protein) contains similarity to Interpro domains IPR001394 (Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2), IPR001607 (Zinc finger, UBP-type)
17	F02H6.7	F02H6.7	n/a	chrIV 14,227,256	contains similarity to Interpro domain IPR000884 (Thrombospondin, type I)
18	srx-2	R03H4.2	n/a	chrV 9,010,093	C. elegans SRX-2 protein; contains similarity to Pfam domain PF01748 Caenorhabditis serpentine receptor-like protein contains similarity to Interpro domain IPR002651 (Protein of unknown function DUF32)
19	M01F1.7	M01F1.7	n/a	chrIII 3,525,420	M01F1.7 encodes a phosphatidylinositol transfer protein, with a C-terminal DDHD domain, that is orthologous to RETINAL DEGENERATION B (RDGB) in D. melanogaster, as well as other orthologs in mammals (NIR1-3); M01F1.7 is expressed in the egg membrane, the germline, the spermatheca and three pairs of head neurons; while M01F1.7 would be expected to mediate PIP(2) signalling in either neuronal function or cytokinesis, it has not yet had a published mutant phenotype, and has no obvious function in mass RNAi assays.
20	W01C9.2	W01C9.2	n/a	chrII 8,537,366	contains similarity to Chlamydia pneumoniae Probable serine/threonine-protein kinase 1 (EC 2.7.1.37).; SW:PKN1_CHLPN
21	srt-5	C50H11.14	n/a	chrV 3,080,169	C. elegans SRT-5 protein; contains similarity to Pfam domain PF01748 Caenorhabditis serpentine receptor-like protein contains similarity to Interpro domain IPR002651 (Protein of unknown function DUF32)
22	unc-122	F11C3.2	n/a	chrI 14,873,757	unc-122 encodes a predicted type II transmembrane protein with extracellular collagen-like domains and a highly conserved olfactomedin (OLF) domain that is found in a family of secreted proteins involved in formation and function of nervous systems; UNC-122 is required for proper locomotion and for normal morphology of the DVB motorneuron, and may regulate neuromuscular function by acting in an aminergic/peptidergic pathway parallel to cholinergic neurotransmission; although mosaic analysis indicates that UNC-122 activity is required in muscle cells, the precise expression and localization patterns of UNC-122 are not yet known.
23	tsp-11	B0563.2	n/a	chrX 9,164,502	C. elegans TSP-11 protein; contains similarity to Pfam domain PF00335 Tetraspanin family contains similarity to Interpro domains IPR000301 (CD9/CD37/CD63 antigen), IPR008952 (Tetraspanin)
24	ncs-3	K03E6.3	n/a	chrX 1,055,449	ncs-3 encodes a neuronal calcium sensor (NCS) protein with no obvious null phenotype.
25	srh-208	C43D7.6	n/a	chrV 19,317,895	This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins.
26	srh-229	C04F2.4	n/a	chrV 7,503,586	C. elegans SRH-229 protein; contains similarity to Pfam domain PF01461 7TM chemoreceptor contains similarity to Interpro domain IPR003002 (7TM chemoreceptor, subfamily 1)
27	sre-52	C50E10.5	n/a	chrII 12,336,826	C. elegans SRE-52 protein; contains similarity to Pfam domain PF03125 C. elegans Sre G protein-coupled chemoreceptor contains similarity to Interpro domains IPR005410 (Potassium channel, two pore-domain, THIK), IPR004151 (C. elegans Sre G protein-coupled chemoreceptor)
28	ZK938.6	ZK938.6	n/a	chrII 9,844,266	contains similarity to Pfam domain PF00704 Glycosyl hydrolases family 18 contains similarity to Interpro domains IPR011583 (Chitinase II), IPR017853 (Glycoside hydrolase, catalytic core), IPR001223 (Glycoside hydrolase, family 18, catalytic domain), IPR013781 (Glycoside hydrolase, subgroup, catalytic core)
29	fbxa-168	C31C9.4	0.00003	chrII 13,647,223	This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; this gene's encoded protein also contains an FTH/DUF38 motif, which may also mediate protein-protein interaction.
30	C53A5.9	C53A5.9	n/a	chrV 14,557,956	contains similarity to Pfam domains PF01344 (Kelch motif) (5), PF07646 (Kelch motif) (3), PF02984 (Cyclin, C-terminal domain) contains similarity to Interpro domains IPR011043 (Galactose oxidase/kelch, beta-propeller), IPR004367 (Cyclin, C-terminal), IPR006652 (Kelch repeat type 1), IPR011498 (Kelch repeat type 2), IPR015916 (Galactose oxidase, beta-propeller), IPR013089 (Kelch related), IPR006651 (Kelch), IPR015915 (Kelch-type beta propeller)
31	cyp-25A5	F42A6.4	n/a	chrIV 3,328,559	C. elegans CYP-25A5 protein; contains similarity to Pfam domain PF00067 Cytochrome P450 contains similarity to Interpro domains IPR001128 (Cytochrome P450), IPR002401 (Cytochrome P450, E-class, group I), IPR002402 (Cytochrome P450, E-class, group II), IPR002403 (Cytochrome P450, E-class, group IV), IPR002397 (Cytochrome P450, B-class)
32	F10E7.2	F10E7.2	n/a	chrII 7,123,253	contains similarity to Schistocerca gregaria Homeobox protein abdominal-A homolog (Fragment).; SW:P29556
33	W10G11.4	W10G11.4	n/a	chrII 3,563,054	contains similarity to Pfam domain PF01579 Domain of unknown function DUF19 contains similarity to Interpro domains IPR016638 (Uncharacterised conserved protein UPF0376), IPR002542 (Protein of unknown function DUF19)
34	T22C8.7	T22C8.7	n/a	chrII 8,632,480	contains similarity to Pfam domain PF00100 Zona pellucida-like domain contains similarity to Interpro domain IPR001507 (Endoglin/CD105 antigen)
35	ZC317.2	ZC317.2	n/a	chrV 5,460,748
36	W02D7.9	W02D7.9	n/a	chrV 8,326,331
37	F25G6.1	F25G6.1	n/a	chrV 8,577,457
38	F52E1.9	F52E1.9	n/a	chrV 8,398,736	contains similarity to Interpro domain IPR011332 (Ribosomal protein, zinc-binding)
39	C01C4.2	C01C4.2	n/a	chrX 3,717,428
40	F23D12.1	F23D12.1	n/a	chrX 14,425,936	contains similarity to Clostridium perfringens Hypothetical protein CPE1252.; TR:Q8XKZ0
41	ifta-1	C54G7.4	n/a	chrX 5,549,123	C. elegans IFTA-1 protein; contains similarity to Pfam domain PF00400 WD domain, G-beta repeat contains similarity to Interpro domains IPR011046 (WD40 repeat-like), IPR017233 (WD repeat protein 35), IPR001680 (WD40 repeat), IPR015943 (WD40/YVTN repeat-like), IPR011011 (Zinc finger, FYVE/PHD-type)
42	C50H2.5	C50H2.5	n/a	chrV 9,919,252	contains similarity to Interpro domains IPR001356 (Homeobox), IPR009057 (Homeodomain-like)
43	sri-31	B0454.2	n/a	chrII 3,051,657	C. elegans SRI-31 protein; contains similarity to Pfam domain PF01461 7TM chemoreceptor contains similarity to Interpro domain IPR003002 (7TM chemoreceptor, subfamily 1)
44	fbxa-3	T08E11.7	5e-47	chrII 1,819,483	This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; this gene's encoded protein also contains an FTH/DUF38 motif, which may also mediate protein-protein interaction.
45	B0212.1	B0212.1	n/a	chrIV 3,575,057	contains similarity to Pfam domain PF03189 Protein of unknown function, DUF270 contains similarity to Interpro domain IPR004878 (Protein of unknown function DUF270)
46	F48C5.1	F48C5.1	n/a	chrX 11,445,448	contains similarity to Pfam domain PF00047 Immunoglobulin domain contains similarity to Interpro domains IPR003598 (Immunoglobulin subtype 2), IPR000742 (EGF-like, type 3), IPR007110 (Immunoglobulin-like), IPR013032 (EGF-like region, conserved site), IPR013151 (Immunoglobulin)
47	srz-47	Y68A4A.2	n/a	chrV 17,191,554	C. elegans SRZ-47 protein ;
48	Y6E2A.1	Y6E2A.1	n/a	chrV 15,710,013	contains similarity to Pfam domain PF01461 7TM chemoreceptor contains similarity to Interpro domains IPR003002 (7TM chemoreceptor, subfamily 1), IPR000832 (GPCR, family 2, secretin-like)
49	ceh-24	F55B12.1	n/a	chrV 13,814,273	ceh-24 is orthologous to the human gene SIMILAR TO THYROID TRANSCRIPTION FACTOR 1 (TITF1; OMIM:600635), which when mutated leads to disease.
50	fbxa-135	T06E6.5	n/a	chrV 15,402,649	This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; this gene's encoded protein also contains an FTH/DUF38 motif, which may also mediate protein-protein interaction.