UCSC C. elegans Gene Sorter

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UCSC C. elegans Gene Sorter

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#	Name	WormBase	BLASTP E-Value	Genome Position	Description
1	T22F7.1	T22F7.1	0	chrIII 544,286	contains similarity to Pfam domains PF07690 (Major Facilitator Superfamily) , PF00083 (Sugar (and other) transporter) contains similarity to Interpro domains IPR007114 (Major facilitator superfamily), IPR006655 (Molybdopterin oxidoreductase, prokaryotic, conserved site), IPR001991 (Sodium:dicarboxylate symporter), IPR011701 (Major facilitator superfamily MFS-1), IPR005828 (General substrate transporter), IPR016196 (MFS general substrate transporter)
2	F25B4.2	F25B4.2	n/a	chrV 5,710,856	contains similarity to Pfam domain PF04710 Pellino contains similarity to Interpro domain IPR006800 (Pellino)
3	hsp-6	C37H5.8	n/a	chrV 4,825,414	hsp-6 encodes a mitochondrial-specific chaperone that is a member of the DnaK/Hsp70 superfamily of molecular chaperones; hsp-6 is believed to be involved in the mitochondrial unfolded protein response, as hsp-6 expression, normally broadly detected from the L1 larval through adult stages of development, is greatly increased in response to treatments that disrupt mitochondrial protein handling; loss of hsp-6 activity via RNAi results in severe growth defects with arrest at embryonic and early larval stages of development.
4	F41G3.2	F41G3.2	n/a	chrII 6,759,863
5	C29G2.3	C29G2.3	n/a	chrV 2,581,907
6	glt-7	W03G1.1	n/a	chrIV 533,911	C. elegans GLT-7 protein; contains similarity to Pfam domain PF00375 Sodium:dicarboxylate symporter family contains similarity to Interpro domain IPR001991 (Sodium:dicarboxylate symporter)
7	C05E7.4	C05E7.4	n/a	chrX 12,966,891	contains similarity to Interpro domain IPR017452 (GPCR, rhodopsin-like superfamily)
8	C46A5.2	C46A5.2	n/a	chrIV 7,761,432	contains similarity to Pfam domain PF00858 Amiloride-sensitive sodium channel contains similarity to Interpro domain IPR001873 (Na+ channel, amiloride-sensitive)
9	srt-1	C13B7.1	n/a	chrV 2,436,754	C. elegans SRT-1 protein; contains similarity to Pfam domain PF01748 Caenorhabditis serpentine receptor-like protein contains similarity to Interpro domain IPR002651 (Protein of unknown function DUF32)
10	C49H3.8	C49H3.8	n/a	chrIV 7,901,218	contains similarity to Pfam domain PF00022 Actin contains similarity to Interpro domains IPR001478 (PDZ/DHR/GLGF), IPR004000 (Actin/actin-like), IPR013126 (Heat shock protein 70)
11	W07E6.3	W07E6.3	n/a	chrII 496,617	contains similarity to Interpro domain IPR000326 (Phosphatidic acid phosphatase type 2/haloperoxidase)
12	Y44E3A.4	Y44E3A.4	n/a	chrI 3,325,798	contains similarity to Pfam domains PF07653 (Variant SH3 domain) (2), PF00018 (SH3 domain) (2)contains similarity to Interpro domains IPR000104 (Antifreeze protein, type I), IPR001452 (Src homology-3), IPR000108 (Neutrophil cytosol factor 2), IPR000694 (Proline-rich region), IPR011511 (Variant SH3), IPR003071 (Orphan nuclear receptor, HMR type)
13	C11D9.1	C11D9.1	n/a	chrI 4,424,085	contains similarity to Pfam domain PF00621 RhoGEF domain contains similarity to Interpro domains IPR000219 (Dbl homology (DH) domain), IPR001478 (PDZ/DHR/GLGF)
14	K10D11.2	K10D11.2	n/a	chrIV 12,980,447	contains similarity to Pfam domain PF02408 CUB-like domain contains similarity to Interpro domain IPR003366 (CUB-like region)
15	vha-1	R10E11.8	n/a	chrIII 9,781,407	vha-1 encodes an ortholog of subunit c of the membrane-bound (V0) domain of vacuolar proton-translocating ATPase (V-ATPase); VHA-1 is a predicted V-ATPase transmembrane rotor component; VHA-1 and VHA-2/3 comprise a closely related family of subunit c co-orthologs, predicted to carry protons from the cytosol to a-subunits (VHA-5, VHA-6, VHA-7, or UNC-32) for transmembrane export; VHA-1, like VHA-12 and VHA-17, antagonizes EFF-1-mediated cell fusion in hypodermal cells; VHA-1 is required for ovulation and embryogenesis, since vha-1(RNAi) animals are sterile with polyploid, unmatured oocytes and dead progeny; VHA-1 is required for alae formation, like the V0 subunits VHA-4 and VHA-5, but not like the V1 subunits VHA-8 or VHA-13; vha-1 shares an operon with vha-2 and R10E11.6; both vha-1 and vha-2 are expressed in the excretory cell, the rectum, and a pair of cells near the anus.
16	C06E1.9	C06E1.9	n/a	chrIII 8,608,051	contains similarity to Interpro domain IPR001680 (WD40 repeat)
17	gta-1	K04D7.3	n/a	chrIV 10,182,270	The gta-1 gene encodes an ortholog of the human gene GABAT, which when mutated leads to GABA-transaminase deficiency (OMIM:137150).
18	F09E10.5	F09E10.5	n/a	chrX 1,492,033
19	pqn-27	E01G4.4	n/a	chrII 13,454,655	The protein product of this gene is predicted to contain a glutamine/asparagine (Q/N)-rich ('prion') domain, by the algorithm of Michelitsch and Weissman (as of the WS77 release of WormBase, i.e., in wormpep77).
20	ZK836.3	ZK836.3	n/a	chrV 12,195,261
21	T26E4.5	T26E4.5	n/a	chrV 15,787,827	contains similarity to Interpro domain IPR008996 ()
22	lgc-5	F17E9.7	n/a	chrIV 8,343,385	C. elegans LGC-5 protein; contains similarity to Pfam domain PF02931 Neurotransmitter-gated ion-channel ligand binding domain contains similarity to Interpro domains IPR006201 (Neurotransmitter-gated ion-channel), IPR006202 (Neurotransmitter-gated ion-channel ligand-binding)
23	T07D3.3	T07D3.3	n/a	chrII 895,627	contains similarity to Homo sapiens CGI16-iso; ENSEMBL:ENSP00000368599
24	F22B8.6	F22B8.6	n/a	chrV 16,101,647	F22B8.6 encodes a putative cystathionine gamma-lyase; F22B8.6 is orthologous to human CTH (OMIM:607657, mutated in cystathioninuria), extremely similar to its paralog ZK1127.10, and also paralogous to C12C8.2; either F22B8.6, or ZK1236.10, or both proteins weakly inhibit DHC-1 in vivo; otherwise, F22B8.6 has no obvious function in mass RNAi assays, perhaps because of genetic redundancy with ZK1127.10.
25	W02A11.1	W02A11.1	n/a	chrI 12,731,353	contains similarity to Pfam domain PF08704 tRNA methyltransferase complex GCD14 subunit contains similarity to Interpro domain IPR014816 (tRNA methyltransferase complex GCD14 subunit)
26	ckb-1	B0285.8	n/a	chrIII 4,366,386	ckb-1 encodes a putative choline kinase; CKB-1 through CKB-4 comprise a related group ('B') of choline kinases.
27	eif-3.E	B0511.10	n/a	chrI 10,641,393	eif-3.E encodes the C. elegans ortholog of the translation initiation factor 3 subunit e (eIF3e/Int-6); by homology, EIF-3.E is predicted to be a component of three different protein complexes, the eIF3 translation initiation factor, the 26S proteasome, and the COP9 signalosome; such association suggests that EIF-3.E may serve as a regulatory factor that coordinates the translational and degradative activities of these various complexes; in C. elegans, large-scale RNAi screens indicate that eif-3.E is required for embryonic, larval, and germline development, as well as proper vulval morphogenesis.
28	K08F4.5	K08F4.5	n/a	chrIV 10,135,380	contains similarity to Paramecium tetraurelia Chromosome undetermined scaffold_96, whole genome shotgun sequence.; TR:A0EH68
29	F56G4.6	F56G4.6	n/a	chrI 11,369,184	contains similarity to Interpro domain IPR001623 (Heat shock protein DnaJ, N-terminal)
30	clec-187	ZK896.6	n/a	chrIV 12,870,360	C. elegans CLEC-187 protein; contains similarity to Pfam domain PF00059 Lectin C-type domain contains similarity to Interpro domains IPR003990 (Pancreatitis-associated protein), IPR016187 (C-type lectin fold), IPR016186 (C-type lectin-like), IPR001304 (C-type lectin)
31	F25H2.7	F25H2.7	n/a	chrI 10,559,067	contains similarity to Pfam domain PF03314 Protein of unknown function, DUF273 contains similarity to Interpro domain IPR004988 (Protein of unknown function DUF273)
32	srw-118	C44C3.5	n/a	chrV 2,979,418	C. elegans SRW-118 protein; contains similarity to Interpro domain IPR017452 (GPCR, rhodopsin-like superfamily)
33	T07D1.5	T07D1.5	n/a	chrX 2,419,146
34	C36B1.9	C36B1.9	n/a	chrI 8,745,380	contains similarity to Pfam domain PF00097 Zinc finger, C3HC4 type (RING finger) contains similarity to Interpro domains IPR001841 (Zinc finger, RING-type), IPR003604 (Zinc finger, U1-type), IPR013083 (Zinc finger, RING/FYVE/PHD-type), IPR000568 (ATPase, F0 complex, subunit A)
35	T23E1.2	T23E1.2	n/a	chrIV 3,144,252
36	W09G10.3	W09G10.3	n/a	chrII 3,526,838	contains similarity to Interpro domains IPR011992 (EF-Hand type), IPR002048 (Calcium-binding EF-hand)
37	Y45F10D.6	Y45F10D.6	n/a	chrIV 13,797,043
38	W06E11.4	W06E11.4	n/a	chrIII 637,463	W06E11.4 encodes an ortholog of human SBDS (OMIM:607444, mutated in Shwachman-Bodian-Diamond syndrome) and S. cerevisiae SDO1; by homology, W06E11.4 is predicted to be a nucleolar protein that may be required for normal processing of rRNA; WS06E11.4 shares an operon with tag-266 and T19C3.7.
39	Y38C9A.1	Y38C9A.1	n/a	chrV 112,782	contains similarity to Leishmania major strain Friedlin Proteophosphoglycan ppg4.; TR:Q4FX63
40	nhr-125	R02D1.1	n/a	chrV 4,322,934	C. elegans NHR-125 protein; contains similarity to Pfam domains PF00104 (Ligand-binding domain of nuclear hormone receptor) , PF00105 (Zinc finger, C4 type (two domains)) contains similarity to Interpro domains IPR008946 (Nuclear hormone receptor, ligand-binding), IPR000324 (Vitamin D receptor), IPR013088 (Zinc finger, NHR/GATA-type), IPR001628 (Zinc finger, nuclear hormone receptor-type), IPR000536 (Nuclear hormone receptor, ligand-binding, core)
41	K01A12.2	K01A12.2	n/a	chrX 8,618,599
42	eif-3.H	C41D11.2	n/a	chrI 4,445,653	C. elegans EIF-3.H protein; contains similarity to Pfam domain PF01398 Mov34/MPN/PAD-1 family contains similarity to Interpro domains IPR000555 (Mov34/MPN/PAD-1), IPR003639 (Mov34-1)
43	ZK596.3	ZK596.3	n/a	chrIV 10,903,190	contains similarity to Mus musculus DNA-dependent protein kinase catalytic subunit (EC 2.7.1.37) (DNA-sPKcs) (P460).; SW:PRKD_MOUSE
44	rpb-4	F43E2.2	n/a	chrII 7,374,771	C. elegans RPB-4 protein; contains similarity to Pfam domain PF03874 RNA polymerase Rpb4 contains similarity to Interpro domains IPR010997 (HRDC-like), IPR005574 (RNA polymerase II, Rpb4), IPR006590 (RNA polymerase II, Rpb4, core)
45	F53F4.3	F53F4.3	n/a	chrV 13,592,537	F53F4.3 encodes a putative alpha-tubulin folding cofactor B, orthologous to human CKAP1 (OMIM:601303); F53F4.3 is dispensable in early embryos for microtubule nucleation or elongation, and has no obvious function in mass RNAi assays.
46	T03G6.3	T03G6.3	n/a	chrX 2,613,474	contains similarity to Pfam domain PF01663 Type I phosphodiesterase / nucleotide pyrophosphatase contains similarity to Interpro domains IPR017849 (Alkaline phosphatase-like, alpha/beta/alpha), IPR002591 (Type I phosphodiesterase/nucleotide pyrophosphatase/phosphate transferase), IPR017850 (Alkaline-phosphatase-like, core domain)
47	C33B4.2	C33B4.2	n/a	chrII 11,371,111	contains similarity to Aristolochia gigantea RPB140 (EC 2.7.7.6) (DNA-directed RNA polymerase beta chain)s(Fragment).; TR:O48912
48	T05E8.3	T05E8.3	n/a	chrI 5,475,882	The T05E8.3 gene encodes a divergent DEAH helicase that is (apparently) unique to Caenorhabditis; it has no well-characterized orthologs in the complete Drosophila or S. cerevisiae genomes, and no obvious orthologs in the draft human genome sequence either.
49	mrt-2	Y41C4A.14	n/a	chrIII 11,748,489	mrt-2 encodes a highly conserved DNA-damage checkpoint protein homologous to the RAD1 protein found in S. pombe, Drosophila, and mammals; MRT-2 interacts with HUS-1 and HPR-9, also conserved DNA-damage checkpoint proteins, and is required in the germline for maintaining chromosomal integrity; mrt-2 mutations result in a failure to induce apoptosis in response to DNA damage, progressive telomere loss, chromosome fusion, and aneuploidy, all leading eventually to germline immortality.
50	F34H10.2	F34H10.2	n/a	chrX 9,630,584	contains similarity to Anabaena sp Hypothetical protein Alr0331.; TR:Q8YZX4