UCSC C. elegans Gene Sorter

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UCSC C. elegans Gene Sorter

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#	Name	WormBase	BLASTP E-Value	Genome Position	Description
1	C43G2.2	C43G2.2	0	chrIV 6,569,098	contains similarity to Interpro domain IPR000533 (Tropomyosin)
2	aff-1	C44B7.3	n/a	chrII 6,862,137	aff-1 encodes a cell-surface protein required in late L4 larvae for various cell fusions, of which at least one (AC-utse) does not require EFF-1; in vulval development, AFF-1 is required for fusion of the anchor cell (AC) with the utse syncytium, of A cells to one another, and of D cells to one another; AFF-1 is also required for lateral seam cell fusions; since aff-1 mutants fail to mix AC with utse cytoplasm, AFF-1 is probably required to begin cell fusion by forming intercellular pores; AFF-1 has no obvious non-nematode orthologs, but is paralogous to EFF-1 and C26D10.7; AFF-1 is predicted to be largely extracellular, with eight conserved predicted disulfide bonds in its ectodomain and a single C-terminal transmembrane domain; AFF-1 is expressed in the AC, beginning around the AC's invasion of basement membrane in mid-L3 larvae, and continuing until the AC's fusion to utse; AFF-1 is also expressed in utse, beginning in L4 larvae, after which AC-utse fusion immediately ensues; in both AC and utse, AFF-1 expression requires FOS-1, and the aff-1 promoter has predicted FOS-1 binding sites; other sites of AFF-1 expression include embryonic hyp5 cells, pharyngeal muscles (Pm3 and Pm5), head and tail neurons, sheath cells of chemosensory neurons, and male tail neurons; subcellularly, AFF-1::GFP localizes to plasma membrane and (undefined) intracellular organelles; generally, AFF-1 is expressed in cells whose fusion does not require EFF-1, which may explain why AFF-1 and EFF-1 are redundantly required for viability; heat shock-driven overexpression of AFF-1, even in an eff-1 null mutant background, can induce ectopic cell fusion, and heterologous AFF-1 can induce insect Sf9 cells to fuse in vitro.
3	F18A11.2	F18A11.2	n/a	chrII 13,034,546	contains similarity to Pfam domain PF00650 CRAL/TRIO domain contains similarity to Interpro domains IPR001251 (Cellular retinaldehyde-binding/triple function, C-terminal), IPR011074 (Phosphatidylinositol transfer protein-like, N-terminal)
4	pmp-2	C44B7.9	n/a	chrII 6,885,843	C. elegans PMP-2 protein; contains similarity to Pfam domains PF06472 (ABC transporter transmembrane region 2) , PF00005 (ABC transporter) contains similarity to Interpro domains IPR003439 (ABC transporter-like), IPR011527 (ABC transporter, transmembrane region, type 1), IPR010509 (ABC transporter, N-terminal), IPR003593 (AAA+ ATPase, core), IPR005283 (Peroxysomal long chain fatty acyl transporter)
5	Y41E3.8	Y41E3.8	n/a	chrIV 15,028,708	contains similarity to Homo sapiens Isoform 1 of H/ACA ribonucleoprotein complex subunit 1; ENSEMBL:ENSP00000226796
6	H22K11.2	H22K11.2	n/a	chrX 6,785,820	contains similarity to Pfam domain PF01301 Glycosyl hydrolases family 35 contains similarity to Interpro domains IPR000583 (Glutamine amidotransferase, class-II), IPR017853 (Glycoside hydrolase, catalytic core), IPR013781 (Glycoside hydrolase, subgroup, catalytic core), IPR001944 (Glycoside hydrolase, family 35)
7	C07B5.2	C07B5.2	n/a	chrX 9,516,733	contains similarity to Listeria monocytogenes Probable tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferases(EC 2.1.1.61).; SW:TRMU_LISMO
8	pat-4	C29F9.7	n/a	chrIII 92,134	The pat-4 gene encodes a serine/threonine kinase orthologous to human integrin-linked kinase (ILK, OMIM:602366) and is required for formation of integrin-mediated muscle cell attachments during embryogenesis; PAT-4 probably functions as an adaptor molecule and localizes to dense bodies and M lines; PAT-4 forms a ternary complex with PAT-6/actopaxin and UNC-112, and requires UNC-112, UNC-52/perlecan, PAT-2/alpha integrin, and PAT-3/beta integrin for proper localization to newly forming integrin adhesion complexes.
9	jph-1	T22C1.7	n/a	chrI 7,948,882	jph-1 encodes a junctophilin, a protein that belongs to a transmembrane family of proteins implicated in the formation of the junctional membrane complex that forms between the plasma membrane and the endoplasmic reticulum in excitable cells; this complex facilitates cross-talk between the cell surface and intracellular ionic channels; RNA interference of jph-1 results in a locomotion defect suggesting impaired body-wall muscle function; a jph-1 promoter-gfp fusion reporter is expressed in all muscle cells and certain neurons of the nerve ring.
10	clec-64	F35C5.7	n/a	chrII 12,899,255	C. elegans CLEC-64 protein; contains similarity to Pfam domain PF00092 von Willebrand factor type A domain contains similarity to Interpro domains IPR016187 (C-type lectin fold), IPR016186 (C-type lectin-like), IPR001304 (C-type lectin), IPR002035 (von Willebrand factor, type A)
11	VT23B5.1	VT23B5.1	n/a	chrIV 12,665,034	contains similarity to Homo sapiens Isoform 2 of WD repeat and FYVE domain-containing protein 3; ENSEMBL:ENSP00000318466
12	F49E11.2	F49E11.2	n/a	chrIV 13,037,470	contains similarity to Interpro domain IPR017452 (GPCR, rhodopsin-like superfamily)
13	syg-2	C26G2.1	n/a	chrX 14,658,836	syg-2 encodes a transmembrane protein that is a member of the immunoglobulin superfamily of proteins; during larval development, SYG-2 activity is required in vulval epithelial cells for proper synaptic specificity of the HSNL neuron; in regulating synapse formation, SYG-2 acts as a guidepost protein for the SYG-1 receptor that interacts with SYG-2 and acts within HSNL to regulate synaptic specificity; a SYG-2::GFP fusion protein is expressed in the primary vulval cell lineages beginning at the L3 larval stage, with expression increasing during the L4 stage and finally disappearing by adulthood; in embryos, SYG-2::GFP expression is detected in some head neurons and body wall muscles, the latter of which also express the reporter during the L1 and L2 larval stages.
14	col-177	F59F3.2	n/a	chrX 11,000,722	C. elegans COL-177 protein; contains similarity to Pfam domain PF01391 Collagen triple helix repeat (20 copies) contains similarity to Interpro domains IPR008161 (Collagen helix repeat), IPR008160 (Collagen triple helix repeat)
15	F53B3.3	F53B3.3	n/a	chrX 2,868,560
16	F45B8.3	F45B8.3	n/a	chrX 14,960,981	contains similarity to Interpro domains IPR003267 (Small proline-rich), IPR000694 (Proline-rich region)
17	T01B6.1	T01B6.1	n/a	chrX 2,342,147	n/a
18	C18E3.3	C18E3.3	n/a	chrI 4,205,990	contains similarity to Staphylococcus saprophyticus subsp saprophyticus Uro-adherence factor A precursor.; SW:Q4A0V8
19	F39H12.1	F39H12.1	n/a	chrX 836,268	contains similarity to Homo sapiens nuclear pore complex-associated protein TPR; ENSEMBL:ENSP00000356448
20	ZC449.5	ZC449.5	n/a	chrX 5,036,581	contains similarity to Lodderomyces elongisporus Putative uncharacterized protein.; TR:A5DYU9
21	dyb-1	F47G6.1	n/a	chrI 1,486,779	The dyb-1 gene encodes a homolog of mammalian alpha-dystrobrevin (DTNA; OMIM:601239), mutation of which can lead to left ventricular noncompaction with congenital heart defects.
22	lgc-34	T27A1.4	n/a	chrII 528,462	C. elegans LGC-34 protein; contains similarity to Pfam domain PF02931 Neurotransmitter-gated ion-channel ligand binding domain contains similarity to Interpro domains IPR000585 (Hemopexin), IPR006028 (Gamma-aminobutyric acid A receptor), IPR006201 (Neurotransmitter-gated ion-channel), IPR006202 (Neurotransmitter-gated ion-channel ligand-binding)
23	rpm-1	C01B7.6	n/a	chrV 8,812,661	rpm-1 encodes an E3 ubiquitin ligase that contains an N-terminal RCC1 (regulator of chromosome condensation)-like guanine nucleotide exchange factor (GEF) domain and that is orthologous to Drosophila highwire and murine Phr1; RPM-1 functions autonomously within several different types of neurons to regulate presynaptic differentiation; in regulating axon termination, RPM-1 acts through the GLO-4 guanine nucleotide exchange factor that positively regulates vesicular trafficking through GLO-1/Rab; in regulating synaptogenesis, RPM-1 functions as part of an SCF-like ubiquitin ligase complex that negatively regulates signaling through the DLK-1 MAP kinase cascade; RPM-1 is expressed in most, if not all, neurons from the comma stage of embryogenesis through adulthood; RPM-1 expression is also seen in the pharynx, coelomocytes, and distal tip cells; in neurons, RPM-1 localizes to presynaptic terminals.
24	F39G3.3	F39G3.3	n/a	chrV 4,732,719	contains similarity to Homo sapiens Isoform 2 of Zinc finger CCCH domain-containing protein 13; ENSEMBL:ENSP00000282007
25	F08G12.1	F08G12.1	n/a	chrX 11,303,901	contains similarity to Pfam domains PF00071 (Ras family) , PF08477 (Miro-like protein) contains similarity to Interpro domains IPR003577 (Ras small GTPase, Ras type), IPR013684 (Miro-like), IPR003578 (Ras small GTPase, Rho type), IPR001806 (Ras GTPase), IPR003579 (Ras small GTPase, Rab type), IPR013753 (Ras)
26	F39E9.1	F39E9.1	n/a	chrII 3,318,116	contains similarity to Pfam domain PF03409 Protein of unknown function (DUF274) contains similarity to Interpro domain IPR005071 (Protein of unknown function DUF274)
27	chs-2	F48A11.1	n/a	chrII 207,689	chs-2 encodes a putative chitin synthase, paralogous to CHS-1; CHS-2 is required for synthesis of chitin lining the inner pharyngeal surface (primarily in the buccal cavity and grinder), while CHS-1 is dispensable for pharyngeal chitin; CHS-2 is also required for normal pharyngeal shape and function, and for larval viability; chs-2(RNAi) animals have abnormally large, misshapen grinders, and arrest as early larvae; chs-2 is expressed by the glandular pharyngeal g1 and g2 cells, and by m3 and m4 myoepithelial cells; chs-2 is transcribed in short periods before each larval molt; the pharyngeal expression of chs-2 parallels gna-1; CHS-2 is predicted to be in the plasma membrane rather than the Golgi apparatus.
28	isw-1	F37A4.8	n/a	chrIII 6,706,964	isw-1 encodes a homolog of the chromatin remodeling ATPase ISW1 that may act downstream of or in parallel to synMuv genes, and upstream of or in parallel to the RTK Ras pathway.
29	gsk-3	Y18D10A.5	n/a	chrI 12,821,999	C. elegans GSK-3 protein; contains similarity to Pfam domain PF00069 Protein kinase domain contains similarity to Interpro domains IPR017441 (Protein kinase ATP binding, conserved site), IPR002290 (Serine/threonine protein kinase), IPR011009 (Protein kinase-like), IPR008271 (Serine/threonine protein kinase, active site), IPR000719 (Protein kinase, core), IPR001245 (Tyrosine protein kinase), IPR017442 (Serine/threonine protein kinase-related)
30	R02D5.1	R02D5.1	n/a	chrV 14,508,925	contains similarity to Saccharomyces cerevisiae Delayed Anaerobic Gene; SGD:YJR151C
31	adm-2	C04A11.4	n/a	chrX 13,691,794	adm-2 encodes a protein containing a snake venom disintegrin-domain and a metalloprotease-like domain (i.e., a protein of the ADAM family); like ADM-1, ADM-2 is homologous to a mammalian sperm glycoprotein (PH-30/fertilin) implicated in sperm-egg fusion, and ADM-2 might thus be a fusogenic protein mediating the merging of plasma membranes during development.
32	hum-7	F56A6.2	n/a	chrI 596,704	hum-7 encodes a class IX unconventional myosin heavy chain that contains a myosin motor domain in the head region and zinc-finger and rhoGAP (rho GTPase activating protein) domains in the tail region; HUM-7 is required during embryogenesis for cytokinesis and normal cytoplasmic rearrangements, and by homology, may function in organization of the actin cytoskeleton; the precise expression and localization patterns of HUM-7 are not yet known.
33	R03H10.7	R03H10.7	n/a	chrII 4,177,232	contains similarity to Pfam domain PF01336 OB-fold nucleic acid binding domain contains similarity to Interpro domains IPR016027 (Nucleic acid-binding, OB-fold-like), IPR012340 (Nucleic acid-binding, OB-fold), IPR004365 (Nucleic acid binding, OB-fold, tRNA/helicase-type)
34	ZK112.3	ZK112.3	n/a	chrIII 7,726,943
35	C18B2.3	C18B2.3	n/a	chrX 3,603,031
36	tag-304	F53E2.1	n/a	chrV 1,469,424	C. elegans TAG-304 protein; contains similarity to Pfam domain PF08513 LisH contains similarity to Interpro domains IPR006594 (LisH dimerisation motif), IPR013144 (CT11-RanBPM), IPR013720 (LisH dimerisation motif, subgroup), IPR006595 (CTLH, C-terminal to LisH motif)
37	T04F8.6	T04F8.6	n/a	chrX 11,669,654	contains similarity to Interpro domain IPR011992 (EF-Hand type)
38	lrk-1	T27C10.6	n/a	chrI 10,886,998	lrk-1 encodes a homolog of GbpC, the primary high-affinity cGMP-binding protein in Dictyostelium discoideum, which is required for normal phosphorylation and cytoskeletal assembly of myosin during chemotaxis; GbpC is generally conserved in eukaryotes, with homologs in mammals and flies.
39	ugt-51	C03A7.11	n/a	chrV 5,176,130	C. elegans UGT-51 protein; contains similarity to Pfam domain PF00201 UDP-glucoronosyl and UDP-glucosyl transferase contains similarity to Interpro domain IPR002213 (UDP-glucuronosyl/UDP-glucosyltransferase)
40	M28.8	M28.8	n/a	chrII 10,630,658	contains similarity to Interpro domain IPR000583 (Glutamine amidotransferase, class-II)
41	D2045.9	D2045.9	n/a	chrIII 10,477,763	contains similarity to Pfam domain PF01755 Glycosyltransferase family 25 (LPS biosynthesis protein) contains similarity to Interpro domains IPR002654 (Glycosyl transferase, family 25), IPR000886 (Endoplasmic reticulum, targeting sequence)
42	nhr-15	F33E11.1	n/a	chrV 321,993	nhr-15 is predicted to encode a member of the nuclear hormone receptor family.
43	F16H11.1	F16H11.1	n/a	chrX 4,670,622	contains similarity to Pfam domain PF07690 Major Facilitator Superfamily contains similarity to Interpro domains IPR011701 (Major facilitator superfamily MFS-1), IPR016196 (MFS general substrate transporter)
44	sgcb-1	K01A2.1	n/a	chrII 327,229	K01A2.1 is orthologous to the human gene SARCOGLYCAN, BETA (43KD DYSTROPHIN-ASSOCIATED GLYCOPROTEIN) (SGCB; OMIM:600900), which when mutated leads to disease.
45	F02D10.4	F02D10.4	n/a	chrX 13,458,404	contains similarity to Emericella nidulans Anucleate primary sterigmata protein B.; SW:APSB_EMENI
46	T24D11.1	T24D11.1	n/a	chrX 16,409,674	contains similarity to Pfam domain PF00566 TBC domain contains similarity to Interpro domain IPR000195 (RabGAP/TBC)
47	lam-1	W03F8.5	n/a	chrIV 5,176,291	lam-1 encodes a laminin beta that affects degenerin-induced cell death and is required redundantly with lam-2 for morphogenesis.
48	R12A1.3	R12A1.3	n/a	chrV 1,424,257	contains similarity to Pfam domains PF07735 (F-box associated) , PF00646 (F-box domain) contains similarity to Interpro domains IPR001810 (Cyclin-like F-box), IPR012885 (F-box associated type 2)
49	T04C9.3	T04C9.3	n/a	chrIII 5,985,695
50	F52G3.1	F52G3.1	n/a	chrX 16,968,223	contains similarity to Pfam domain PF07001 BAT2 N-terminus contains similarity to Interpro domains IPR009738 (BAT2, N-terminal), IPR000694 (Proline-rich region)