UCSC C. elegans Gene Sorter

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UCSC C. elegans Gene Sorter

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#	Name	WormBase	BLASTP E-Value	Genome Position	Description
1	F13D12.9	F13D12.9	0	chrII 11,708,413	contains similarity to Pfam domains PF02353 (Cyclopropane-fatty-acyl-phospholipid synthase) , PF08242 (Methyltransferase domain) , PF08241 (Methyltransferase domain) contains similarity to Interpro domains IPR003333 (Cyclopropane-fatty-acyl-phospholipid synthase), IPR013217 (Methyltransferase type 12), IPR013216 (Methyltransferase type 11)
2	erv-46	K09E9.2	n/a	chrX 15,615,388	C. elegans ERV-46 protein; contains similarity to Pfam domain PF07970 Protein of unknown function (DUF1692) contains similarity to Interpro domain IPR012936 (Protein of unknown function DUF1692)
3	cpt-4	K11D12.4	n/a	chrV 5,025,698	C. elegans CPT-4 protein; contains similarity to Pfam domain PF00755 Choline/Carnitine o-acyltransferase contains similarity to Interpro domains IPR000542 (Acyltransferase ChoActase/COT/CPT), IPR000169 (Peptidase, cysteine peptidase active site)
4	mlt-11	W01F3.3	n/a	chrV 20,668,250	C. elegans MLT-11 protein; contains similarity to Pfam domains PF00014 (Kunitz/Bovine pancreatic trypsin inhibitor domain) (10), PF00086 (Thyroglobulin type-1 repeat) contains similarity to Interpro domains IPR000716 (Thyroglobulin type-1), IPR002223 (Proteinase inhibitor I2, Kunitz metazoa), IPR000694 (Proline-rich region), IPR006150 (Cysteine-rich repeat)
5	nhr-259	C27C7.8	n/a	chrI 11,437,084	C. elegans NHR-259 protein; contains similarity to Pfam domain PF00104 Ligand-binding domain of nuclear hormone receptor contains similarity to Interpro domains IPR008946 (Nuclear hormone receptor, ligand-binding), IPR000536 (Nuclear hormone receptor, ligand-binding, core)
6	dnj-7	C55B6.2	n/a	chrX 7,196,372	This gene encodes a protein containing a DnaJ ('J') domain that is predicted to be mitochondrial.
7	F19H8.4	F19H8.4	n/a	chrII 14,619,275	contains similarity to Pfam domain PF04870 Protein of unknown function, DUF644 contains similarity to Interpro domain IPR006954 (Protein of unknown function DUF644)
8	nhr-45	F16H11.5	n/a	chrX 4,658,348	C. elegans NHR-45 protein; contains similarity to Pfam domains PF00104 (Ligand-binding domain of nuclear hormone receptor) , PF00105 (Zinc finger, C4 type (two domains)) contains similarity to Interpro domains IPR008946 (Nuclear hormone receptor, ligand-binding), IPR000324 (Vitamin D receptor), IPR013088 (Zinc finger, NHR/GATA-type), IPR001628 (Zinc finger, nuclear hormone receptor-type), IPR000536 (Nuclear hormone receptor, ligand-binding, core)
9	K09F6.3	K09F6.3	n/a	chrII 2,258,704	contains similarity to Pfam domains PF02206 (Domain of unknown function) , PF00102 (Protein-tyrosine phosphatase) contains similarity to Interpro domains IPR003595 (Protein-tyrosine phosphatase, catalytic), IPR016130 (Protein-tyrosine phosphatase, active site), IPR000242 (Protein-tyrosine phosphatase, receptor/non-receptor type), IPR000387 (Protein-tyrosine phosphatase), IPR003125 (Protein of unknown function WSN)
10	pfn-3	K03E6.6	n/a	chrX 1,080,056	C. elegans PFN-3 protein; contains similarity to Pfam domain PF00235 Profilin contains similarity to Interpro domains IPR002097 (Profilin/allergen), IPR005455 (Profilin, plant)
11	T17H7.1	T17H7.1	n/a	chrIII 741,822	contains similarity to Pfam domain PF02520 Domain of unknown function DUF148 contains similarity to Interpro domains IPR002952 (Eggshell protein), IPR003677 (Protein of unknown function DUF148)
12	B0238.10	B0238.10	n/a	chrV 5,274,794	contains similarity to Pfam domain PF00583 Acetyltransferase (GNAT) family contains similarity to Interpro domains IPR000182 (GCN5-related N-acetyltransferase), IPR016181 (Acyl-CoA N-acyltransferase)
13	B0272.4	B0272.4	n/a	chrX 9,429,267	contains similarity to Pfam domain PF00378 Enoyl-CoA hydratase/isomerase family contains similarity to Interpro domain IPR001753 (Crotonase, core)
14	T21B6.3	T21B6.3	n/a	chrX 10,946,988	The protein product of this gene is predicted to contain a glutamine/asparagine (Q/N)-rich ('prion') domain, by the algorithm of Michelitsch and Weissman (as of the WS77 release of WormBase, i.e., in wormpep77).
15	sec-24.1	F12F6.6	n/a	chrIV 11,564,055	sec-24.1 encodes one of two C. elegans Sec24 homologs; in Saccharomyces cerevisiae, Sec24 is a member of the Sec24-Sec23 subunit of the COPII coat complex, assembly of which is essential for the first step of secretory protein transport from the endoplasmic reticulum (ER) to the Golgi; by homology with Sec24, SEC-24.1 is predicted to facilitate vesicle cargo selection, and likely contains multiple, independent sites for binding to secreted proteins; loss of sec-24.1 activity via RNAi indicates that SEC-24.1 is required for cuticle secretion and oogenesis.
16	ZK1025.7	ZK1025.7	n/a	chrI 11,466,357	contains similarity to Pfam domain PF01697 Domain of unknown function contains similarity to Interpro domain IPR008166 (Protein of unknown function DUF23)
17	ZC123.1	ZC123.1	n/a	chrI 839,873	contains similarity to Interpro domains IPR000381 (Inhibin, beta B subunit), IPR003267 (Small proline-rich), IPR000694 (Proline-rich region), IPR000480 (Glutelin)
18	Y54E2A.7	Y54E2A.7	n/a	chrII 14,772,378	contains similarity to Saccharomyces cerevisiae DNA Helicase; identified as an ExtraCellular Mutant; homology exists between ECM32 and two other identified DNA helicases, DNA2 and NAM7; SGD:YER176W
19	nhr-73	C27C7.4	n/a	chrI 11,434,790	nhr-73 encodes a member of the superfamily of nuclear receptors, which is one of the most abundant class of transcriptional regulators; nuclear receptors have a well conserved DNA binding domain and a less conserved C-terminal ligand binding domain; expression studies using GFP fusions indicate that nhr-73 is expressed exclusively in lateral seam cells; expression of nhr-73 is seen in early embryonic lateral hypodermal cells and continues to persist in the daughter cell that continues to divide and is lost in the daughter cell that differentiates; nhr-73 expression is diminished by knocking down genes (via RNA interference) that are involved in seam cell development like elt-5 and ceh-16/engrailed.
20	let-721	C05D11.12	n/a	chrIII 6,445,833	The let-721 gene encodes an ortholog of the human gene SIMILAR TO ELECTRON-TRANSFERRING-FLAVOPROTEIN DEHYDROGENASE (ETFDH), which when mutated leads to glutaricaciduria type IIC (OMIM:231675).
21	imp-2	T05E11.5	n/a	chrIV 11,117,784	C. elegans IMP-2 protein; contains similarity to Pfam domain PF04258 Signal peptide peptidase contains similarity to Interpro domains IPR006639 (Peptidase A22, presenilin signal peptide), IPR007369 (Peptidase A22B, signal peptide peptidase)
22	C14A4.8	C14A4.8	n/a	chrII 10,597,545	contains similarity to Interpro domains IPR008962 (PapD-like), IPR000535 (Major sperm protein)
23	sec-23	Y113G7A.3	n/a	chrV 20,093,804	C. elegans SEC-23 protein; contains similarity to Pfam domains PF04811 (Sec23/Sec24 trunk domain) , PF04815 (Sec23/Sec24 helical domain) , PF04810 (Sec23/Sec24 zinc finger) , PF00626 (Gelsolin repeat) , PF08033 (Sec23/Sec24 beta-sandwich domain) contains similarity to Interpro domains IPR006900 (Sec23/Sec24 helical region), IPR012990 (Sec23/Sec24 beta-sandwich), IPR006896 (Sec23/Sec24 trunk region), IPR006895 (Zinc finger, Sec23/Sec24-type), IPR007123 (Gelsolin region)
24	Y45G12C.3	Y45G12C.3	n/a	chrV 2,556,848	contains similarity to Pfam domain PF02798 Glutathione S-transferase, N-terminal domain contains similarity to Interpro domains IPR012336 (Thioredoxin-like fold), IPR012335 (Thioredoxin fold), IPR004045 (Glutathione S-transferase, N-terminal), IPR010987 (Glutathione S-transferase, C-terminal-like)
25	Y25C1A.13	Y25C1A.13	n/a	chrII 3,110,294	contains similarity to Pfam domain PF00378 Enoyl-CoA hydratase/isomerase family contains similarity to Interpro domains IPR014748 (Crontonase, C-terminal), IPR001753 (Crotonase, core)
26	F10D2.10	F10D2.10	n/a	chrV 7,155,368	contains similarity to Pfam domain PF06342 Alpha/beta hydrolase of unknown function (DUF1057) contains similarity to Interpro domain IPR010463 (Protein of unknown function DUF1057, lipase putative)
27	F47B3.6	F47B3.6	n/a	chrI 3,966,408	contains similarity to Pfam domain PF00102 Protein-tyrosine phosphatase contains similarity to Interpro domains IPR003595 (Protein-tyrosine phosphatase, catalytic), IPR016130 (Protein-tyrosine phosphatase, active site), IPR000242 (Protein-tyrosine phosphatase, receptor/non-receptor type), IPR000387 (Protein-tyrosine phosphatase)
28	Y39G8C.2	Y39G8C.2	n/a	chrII 14,096,329	contains similarity to Pfam domain PF00069 Protein kinase domain contains similarity to Interpro domains IPR017441 (Protein kinase ATP binding, conserved site), IPR002290 (Serine/threonine protein kinase), IPR011009 (Protein kinase-like), IPR000719 (Protein kinase, core), IPR001245 (Tyrosine protein kinase), IPR017442 (Serine/threonine protein kinase-related)
29	T26C5.2	T26C5.2	n/a	chrII 9,234,631	contains similarity to Pfam domain PF00024 PAN domain contains similarity to Interpro domains IPR003609 (Apple-like), IPR003014 (N/apple PAN)
30	ben-1	C54C6.2	n/a	chrIII 3,539,934	A beta-tubulin that confers benzimidazole sensitivity.
31	W04G3.5	W04G3.5	n/a	chrX 11,074,823	contains similarity to Pfam domain PF00156 Phosphoribosyl transferase domain contains similarity to Interpro domains IPR005946 (Phosphoribosyl pyrophosphokinase), IPR000836 (Phosphoribosyltransferase)
32	T03G6.1	T03G6.1	n/a	chrX 2,609,102
33	F40E10.5	F40E10.5	n/a	chrX 14,702,656	contains similarity to Onchocerca volvulus OV39 antigen (Fragment).; SW:P31730
34	F21C10.7	F21C10.7	n/a	chrV 9,117,429	contains similarity to Pfam domains PF07686 (Immunoglobulin V-set domain) (2), PF00047 (Immunoglobulin domain) (3), PF07679 (Immunoglobulin I-set domain) (6)contains similarity to Interpro domains IPR003598 (Immunoglobulin subtype 2), IPR002017 (Spectrin repeat), IPR013098 (Immunoglobulin I-set), IPR013783 (Immunoglobulin-like fold), IPR013106 (Immunoglobulin V-set), IPR007110 (Immunoglobulin-like), IPR003599 (Immunoglobulin subtype), IPR013151 (Immunoglobulin)
35	mec-12	C44B11.3	n/a	chrIII 3,135,388	mec-12 encodes a novel C. elegans alpha-tubulin that is unique amongst C. elegans alpha tubulins in that it may be subject to post-translational acetylation; MEC-12 is required for normal mechanosensory response to gentle touch, and specifically for formation of the 15-protofilament microtubule bundle present in the touch receptor neurons; mec-12 interacts genetically with mec-5, which encodes a unique C. elegans collagen secreted by the hypodermis; MEC-12 is highly expressed in the touch neurons as well as in several other neurons that do not contains the microfilament bundle, such as the ventral cord motorneurons.
36	C34F6.1	C34F6.1	n/a	chrX 11,194,603	contains similarity to Pfam domain PF00014 Kunitz/Bovine pancreatic trypsin inhibitor domain contains similarity to Interpro domains IPR002223 (Proteinase inhibitor I2, Kunitz metazoa), IPR000694 (Proline-rich region), IPR006150 (Cysteine-rich repeat)
37	T27F6.1	T27F6.1	n/a	chrI 12,472,050	contains similarity to Pfam domain PF02485 Core-2/I-Branching enzyme contains similarity to Interpro domain IPR003406 (Glycosyl transferase, family 14)
38	F42A10.3	F42A10.3	n/a	chrIII 6,156,244	contains similarity to Pfam domain PF01234 NNMT/PNMT/TEMT family contains similarity to Interpro domain IPR000940 (Methyltransferase, NNMT/PNMT/TEMT)
39	nas-15	T04G9.2	n/a	chrX 779,117	nas-15 encodes an astacin-like metalloprotease.
40	dod-21	C32H11.10	n/a	chrIV 12,937,319	C. elegans DOD-21 protein; contains similarity to Pfam domain PF02408 CUB-like domain contains similarity to Interpro domain IPR003366 (CUB-like region)
41	atp-2	C34E10.6	n/a	chrIII 5,229,290	atp-2 encodes the beta subunit of the soluble, catalytic F1 portion of ATP synthase (mitochondrial respiratory chain [MRC] complex V); atp-2 activity is required for embryonic and larval development past the L3 stage, as well as for normal mobility, pharyngeal pumping, defecation, growth rate, and larval lifespan; in males, atp-2 activity is also required cell autonomously in male-specific sensory neurons for response to hermaphrodite contact, the first step in a series of stereotypical male mating behaviors; in vitro, the N-terminus of ATP-2 interacts directly with the conserved PLAT domains of human polycystin (PC)-1 and C. elegans LOV-1, which is expressed exclusively in adult male sensory neurons and is also required for the response to hermaphrodite contact; atp-2 is widely expressed throughout development in both sexes; ATP-2 localizes to mitochondria and to cilia of male-specific neurons; in the male-specific CEM neurons ATP-2 colocalizes with PKD-2, the C. elegans homolog of human polycystin (PC)-2.
42	F20G2.3	F20G2.3	n/a	chrV 13,767,197	contains similarity to Pfam domains PF01105 (emp24/gp25L/p24 family/GOLD) , PF00650 (CRAL/TRIO domain) contains similarity to Interpro domains IPR001251 (Cellular retinaldehyde-binding/triple function, C-terminal), IPR011074 (Phosphatidylinositol transfer protein-like, N-terminal), IPR000348 (emp24/gp25L/p24)
43	ldh-1	F13D12.2	n/a	chrII 11,725,839	ldh-1 is orthologous to the human gene LACTATE DEHYDROGENASE B (LDHB; OMIM:150100), which when mutated leads to lactate dehydrogenase-B deficiency.
44	T20D4.3	T20D4.3	n/a	chrV 3,420,496	contains similarity to Pfam domain PF04721 Domain of unknown function (DUF750) contains similarity to Interpro domain IPR006588 (Protein of unknown function PAW)
45	R06B10.1	R06B10.1	n/a	chrIII 969,326	contains similarity to Pfam domains PF02206 (Domain of unknown function) , PF00102 (Protein-tyrosine phosphatase) contains similarity to Interpro domains IPR003595 (Protein-tyrosine phosphatase, catalytic), IPR016130 (Protein-tyrosine phosphatase, active site), IPR000242 (Protein-tyrosine phosphatase, receptor/non-receptor type), IPR000387 (Protein-tyrosine phosphatase), IPR003125 (Protein of unknown function WSN)
46	unc-68	K11C4.5	n/a	chrV 6,915,345	unc-68 encodes a ryanodine receptor ortholog that is expressed in body-wall muscle cells and is required for normal body tension and locomotion; unc-68 mutants are flaccid, sluggish, and resistant to ryanodine, but have normal muscle ultrastructure; UNC-68 is dispensable for excitation-contraction coupling itself, but may amplify its calcium signals; the unc-68/kra-1(kh30) mutation is an S1444N substitution at a putative protein kinase C phosphorylation site; UNC-68 reduced unc-103(sy557)-induced spicule protraction by one half; unc-68 is orthologous to the human genes RYR1 (OMIM:180901, mutated in malignant hyperthermia and central core disease), RYR2 (OMIM:180902, mutated in stress-induced polymorphic ventricular tachycardia), and RYR3 (OMIM:180903).
47	clec-186	ZK896.7	n/a	chrIV 12,867,615	C. elegans CLEC-186 protein; contains similarity to Pfam domain PF00059 Lectin C-type domain contains similarity to Interpro domains IPR016187 (C-type lectin fold), IPR016186 (C-type lectin-like), IPR001304 (C-type lectin)
48	hex-2	C14C11.3	n/a	chrV 5,656,509	hex-2 encodes a beta-N-acetylhexosaminidase.
49	R03H4.6	R03H4.6	n/a	chrV 9,023,568	contains similarity to Pfam domain PF01757 Acyltransferase family contains similarity to Interpro domain IPR002656 (Acyltransferase 3)
50	dre-1	K04A8.6	n/a	chrV 6,535,821	dre-1 encodes an ortholog of human FBXO11/PRMT9 (OMIM:607871, associated with vitiligo and otitis media) that is required, in conjunction with DAF-12 and its partners, for global developmental timing of the transistion from larval to adult cell fates; DRE-1 has an N-terminal F-box domain, three central tandem C-terminal CASH domains, and a C-terminal zinc finger; hypomorphic dre-1 mutations are synthetically heterochronic with loss-of-function daf-12 alleles, inducing defective distal tip cell migration and precocious fusion of seam cells; five different hypomorphic dre-1 alleles alter conserved glycine residues in the CASH domain region, whereas the null dre-1(hd60) allele is lethal at the three-fold embryo stage; DRE-1 is expressed in many tissues, including epidermal and distal tip cells, and localizes to both nucleus and cytoplasm; strong loss-of-function of dre-1 (the dh99 mutant fed RNAi) induces defects at all four molts; dre-1 also has synthetic phenotypes with daf-9(k182), daf-36(k114), and lin-29(n546); dre-1-like enhancement of daf-12 is also seen in skr-1(RNAi), cul-1(RNAi), or rbx-1/2(RNAi) animals; DRE-1 and SKR-1 bind one another, as do their human orthologs; DRE-1 affects lin-29 expression, and is suppressed by lin-42(RNAi); DRE-1 is paralogous to C. elegans BE0003N10.3.