UCSC C. elegans Gene Sorter

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UCSC C. elegans Gene Sorter

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#	Name	WormBase	BLASTP E-Value	Genome Position	Description
1	F16G10.1	F16G10.1	4e-99	chrII 2,402,918	contains similarity to Pfam domain PF02343 Domain of unknown function DUF130 contains similarity to Interpro domain IPR003326 (Protein of unknown function DUF130)
2	Y75B8A.34	Y75B8A.34	n/a	chrIII 12,360,286	contains similarity to Homo sapiens Kappa-type opioid receptor; ENSEMBL:ENSP00000265572
3	old-1	C08H9.5	n/a	chrII 9,867,626	old-1 encodes a receptor protein tyrosine kinase; old-1 activity is required for stress resistance and regulation of adult lifespan: old-1 mRNA expression is upregulated in response to stress and in daf-2 and age-1 mutant backgrounds; likewise, overexpression of old-1 in wild-type animals extends lifespan and increases resistance to heat and UV irradiation; an OLD-1::GFP fusion protein is expressed in the anterior region of worms, in neuronal, hypodermal, and pharyngeal tissues, as well as in the proximal region of the male gonad; expression is visible in young adults and appears to increase as animals age and in response to heat, starvation, or UV irradiation.
4	tbx-9	T07C4.6	n/a	chrIII 10,340,812	C. elegans TBX-9 protein; contains similarity to Pfam domain PF00907 T-box contains similarity to Interpro domains IPR008967 (p53-like transcription factor, DNA-binding), IPR001699 (Transcription factor, T-box)
5	M70.5	M70.5	n/a	chrIV 2,270,286	contains similarity to Pfam domain PF01436 NHL repeat contains similarity to Interpro domains IPR011042 (Six-bladed beta-propeller, TolB-like), IPR001258 (NHL repeat)
6	T24A6.16	T24A6.16	n/a	chrV 3,562,186	contains similarity to Pfam domain PF04590 Protein of unknown function, DUF595 contains similarity to Interpro domain IPR007669 (Protein of unknown function DUF595)
7	clec-46	F07C4.9	n/a	chrV 7,637,516	C. elegans CLEC-46 protein; contains similarity to Pfam domain PF00059 Lectin C-type domain contains similarity to Interpro domains IPR016187 (C-type lectin fold), IPR016186 (C-type lectin-like), IPR001304 (C-type lectin)
8	F41E6.8	F41E6.8	n/a	chrV 8,600,475	contains similarity to Pfam domain PF03380 Caenorhabditis protein of unknown function, DUF282 contains similarity to Interpro domain IPR005044 (Protein of unknown function DUF282, Caenorhabditis species)
9	nhr-190	F48G7.11	n/a	chrV 641,845	C. elegans NHR-190 protein; contains similarity to Pfam domains PF00104 (Ligand-binding domain of nuclear hormone receptor) , PF00105 (Zinc finger, C4 type (two domains)) contains similarity to Interpro domains IPR008946 (Nuclear hormone receptor, ligand-binding), IPR000324 (Vitamin D receptor), IPR013088 (Zinc finger, NHR/GATA-type), IPR001628 (Zinc finger, nuclear hormone receptor-type), IPR000536 (Nuclear hormone receptor, ligand-binding, core)
10	H25K10.4	H25K10.4	n/a	chrIV 16,226,802	contains similarity to Pseudomonas putida Hypothetical protein.; TR:Q8VMP3
11	Y102E9.3	Y102E9.3	n/a	chrIII 6,734,194
12	srj-6	F31F4.8	n/a	chrV 653,904	C. elegans SRJ-6 protein; contains similarity to Pfam domain PF01461 7TM chemoreceptor contains similarity to Interpro domain IPR003002 (7TM chemoreceptor, subfamily 1)
13	C37C3.7	C37C3.7	n/a	chrV 7,836,124	contains similarity to Interpro domains IPR000742 (EGF-like, type 3), IPR006210 (EGF), IPR002049 (EGF-like, laminin), IPR013032 (EGF-like region, conserved site)
14	F58E2.2	F58E2.2	n/a	chrIV 3,470,373
15	str-236	K02H11.3	n/a	chrV 1,527,292	C. elegans STR-236 protein; contains similarity to Pfam domain PF01461 7TM chemoreceptor contains similarity to Interpro domains IPR003002 (7TM chemoreceptor, subfamily 1), IPR003567 (Cytochrome c-type biogenesis protein)
16	K02F3.7	K02F3.7	n/a	chrIII 836,776
17	gcy-23	T26C12.4	n/a	chrIV 3,286,107	gcy-23 encodes a receptor-type guanylyl cyclase that, along with gcy-8 and gcy-18, constitutes a subfamily of guanylyl cyclase genes in C. elegans; gcy-23 functions redundantly with gcy-8 and gcy-18, and upstream of tax-4, to regulate thermotaxis via the AFD thermosensory neurons, although of the three guanylyl cyclases required, genetic analyses suggest that GCY-18 is the primary guanylyl cyclase required; in addition, loss of gcy-23 activity via RNAi results in lifespan extension; GCY-23 is expressed exclusively in the AFD thermosensory neurons, where it localizes to sensory endings.
18	nas-16	K03B8.1	n/a	chrV 11,392,697	nas-16 encodes an astacin-like metalloprotease.
19	C45E5.2	C45E5.2	n/a	chrIV 5,742,716	contains similarity to Pfam domain PF00704 Glycosyl hydrolases family 18 contains similarity to Interpro domains IPR011583 (Chitinase II), IPR017853 (Glycoside hydrolase, catalytic core), IPR001223 (Glycoside hydrolase, family 18, catalytic domain), IPR013781 (Glycoside hydrolase, subgroup, catalytic core)
20	C40A11.5	C40A11.5	n/a	chrII 2,134,686	contains similarity to Pfam domain PF00102 Protein-tyrosine phosphatase contains similarity to Interpro domains IPR003595 (Protein-tyrosine phosphatase, catalytic), IPR000242 (Protein-tyrosine phosphatase, receptor/non-receptor type), IPR000387 (Protein-tyrosine phosphatase)
21	F44G3.10	F44G3.10	n/a	chrV 16,139,209	F44G3.10 encodes a claudin homolog that may be required for normal cohesion of apical junctions in epithelia; F44G3.10 is worm-specific, with obvious homologs only in C. elegans; F44G3.10 has no obvious function in mass RNAi assays; claudins are integral membrane proteins with four transmembrane sequences that are found in mammalian tight junctions (TJs), induce TJs when transgenically expressed in cells normally lacking them, and can mediate the specific conductance of of specific ions (e.g., magnesium or calcium) through TJs while blocking the flow of water.
22	F16G10.8	F16G10.8	3e-27	chrII 2,382,692	contains similarity to Pfam domain PF02343 Domain of unknown function DUF130 contains similarity to Interpro domain IPR003326 (Protein of unknown function DUF130)
23	srw-84	Y43F8A.4	n/a	chrV 19,382,978	C. elegans SRW-84 protein; contains similarity to Interpro domain IPR017452 (GPCR, rhodopsin-like superfamily)
24	F56C3.7	F56C3.7	n/a	chrX 1,370,660
25	clec-114	C49A1.9	n/a	chrI 14,233,796	C. elegans CLEC-114 protein; contains similarity to Interpro domains IPR006583 (CW), IPR016187 (C-type lectin fold)
26	C06B3.7	C06B3.7	n/a	chrV 13,910,615	contains similarity to Streptococcus agalactiae Tn5252, relaxase.; TR:Q8DZ67
27	C24A8.1	C24A8.1	n/a	chrX 4,323,582	C24A8.1 encodes an homolog of mammalian D2 or D3 dopamine receptors, and a paralog of DOP-2/-3; C24A8.1 is expressed in the nervous system; because of its paralogy, C24A8.1 might act redundantly with DOP-2 to promote the basal slowing response to bacterial feeding, or it might account for the residual response to excess dopamine seen in triple dop-1/-2/-3 mutants; but C24A8.1 otherwise has no obvious function in RNAi assays of brood size, egg laying, pharyngeal pumping, locomotion, or male mating.
28	C08B6.10	C08B6.10	n/a	chrV 10,126,265	contains similarity to Interpro domains IPR006030 (Molluscan rhodopsin C-terminal tail), IPR000694 (Proline-rich region)
29	C17H1.3	C17H1.3	n/a	chrI 13,105,263	contains similarity to Trichomonas vaginalis G3 Smooth muscle caldesmon, putative.; TR:A2FBI1
30	ZK380.2	ZK380.2	n/a	chrX 1,633,167	contains similarity to Interpro domain IPR011072 (HR1 rho-binding repeat)
31	srj-5	F31F4.16	n/a	chrV 652,439	C. elegans SRJ-5 protein; contains similarity to Pfam domain PF01461 7TM chemoreceptor contains similarity to Interpro domain IPR003002 (7TM chemoreceptor, subfamily 1)
32	cnc-5	R09B5.10	n/a	chrV 1,445,607	cnc-5 encodes one of six C. elegans caenacin peptides; CNC-5 is predicted to be a secreted protein that, based upon similarity to CNC-2, -4, and -6, may function as an antimicrobial peptide in the innate immune response.
33	srh-298	Y94A7B.5	n/a	chrV 17,819,902	C. elegans SRH-298 protein; contains similarity to Pfam domain PF01461 7TM chemoreceptor contains similarity to Interpro domain IPR003002 (7TM chemoreceptor, subfamily 1)
34	R10E8.5	R10E8.5	n/a	chrV 18,255,890	contains similarity to Pfam domain PF01461 7TM chemoreceptor contains similarity to Interpro domain IPR003002 (7TM chemoreceptor, subfamily 1)
35	math-31	F52C6.6	n/a	chrII 1,912,654	C. elegans MATH-31 protein; contains similarity to Pfam domain PF00917 MATH domain contains similarity to Interpro domains IPR008974 (TRAF-like), IPR002083 (MATH)
36	str-257	C01B4.1	n/a	chrV 2,519,650	C. elegans STR-257 protein; contains similarity to Pfam domain PF01461 7TM chemoreceptor contains similarity to Interpro domain IPR003002 (7TM chemoreceptor, subfamily 1)
37	T10E9.5	T10E9.5	n/a	chrI 6,522,462
38	T22E5.6	T22E5.6	n/a	chrX 6,415,238	contains similarity to Interpro domain IPR002016 (Haem peroxidase, plant/fungal/bacterial)
39	C27F2.1	C27F2.1	n/a	chrIII 4,989,295	contains similarity to Interpro domains IPR011046 (WD40 repeat-like), IPR001680 (WD40 repeat), IPR015943 (WD40/YVTN repeat-like)
40	C36B7.2	C36B7.2	n/a	chrX 7,106,598	contains similarity to Pfam domain PF00069 Protein kinase domain contains similarity to Interpro domains IPR002290 (Serine/threonine protein kinase), IPR011009 (Protein kinase-like), IPR008271 (Serine/threonine protein kinase, active site), IPR000719 (Protein kinase, core), IPR001245 (Tyrosine protein kinase), IPR017442 (Serine/threonine protein kinase-related)
41	W04G5.3	W04G5.3	n/a	chrI 11,629,776	contains similarity to Arabidopsis thaliana Probable WRKY transcription factor 19 (WRKY DNA-binding protein 19).; SW:WR19_ARATH
42	ZK1055.5	ZK1055.5	n/a	chrV 6,582,618	contains similarity to Pfam domain PF03269 Caenorhabditis protein of unknown function, DUF268 contains similarity to Interpro domain IPR004951 (Protein of unknown function DUF268, Caenorhabditis species)
43	nas-39	F38E9.2	n/a	chrX 16,464,603	C. elegans NAS-39 protein; contains similarity to Pfam domains PF00008 (EGF-like domain) (2), PF07645 (Calcium binding EGF domain) (2), PF00431 (CUB domain) (4), PF01400 (Astacin (Peptidase family M12A)) contains similarity to Interpro domains IPR015446 (Bone morphogenetic protein 1/tolloid-like protein), IPR000742 (EGF-like, type 3), IPR006209 (EGF-like), IPR006025 (Peptidase M, neutral zinc metallopeptidases, zinc-binding site), IPR000152 (Aspartic acid and asparagine hydroxylation site), IPR001506 (Peptidase M12A, astacin), IPR006210 (EGF), IPR006026 (Peptidase, metallopeptidases), IPR000859 (CUB), IPR001881 (EGF-like calcium-binding), IPR013032 (EGF-like region, conserved site), IPR013091 (EGF calcium-binding)
44	F58F9.1	F58F9.1	n/a	chrIV 6,251,691	contains similarity to Pfam domain PF00268 Ribonucleotide reductase, small chain contains similarity to Interpro domains IPR012348 (Ribonucleotide reductase-related), IPR000358 (Ribonucleotide reductase), IPR009078 (Ferritin/ribonucleotide reductase-like)
45	rac-2	K03D3.10	n/a	chrIV 16,308,987	rac-2 encodes a small Rho family GTPase that, along with CED-10 and MIG-2, is one of three C. elegans Rac-related proteins; genetic studies indicate that rac-2 functions redundantly with mig-2 and ced-10 to regulate CAN and PDE axon pathfinding and CAN cell migration; in addition, rac-2 functions slightly redundant with mig-2 during distal tip cell movement and slightly redundant with ced-10 during cell-corpse phagocytosis; as unc-73 mutations enhance rac-2 defects in axon pathfinding and CAN cell migration, UNC-73/Trio is a likely candidate to act upstream of RAC-2 and positively regulate its GTPase activity in vivo; further, as UNC-115 activity is required to mediate the morphogenetic effects of constitutively active RAC-2(G12V), UNC-115, an actin-binding protein, is likely to be a downstream effector of RAC-2; GFP::RAC-2 reporters expressed in neurons and neuroblasts reveal localization at cell margins and the nerve ring, the latter suggesting that GFP::RAC-2 associates with the axonal plasma membrane.
46	srw-143	H27D07.3	n/a	chrV 2,940,553	C. elegans SRW-143 protein; contains similarity to Interpro domain IPR017452 (GPCR, rhodopsin-like superfamily)
47	T05C12.8	T05C12.8	n/a	chrII 8,189,001	contains similarity to Interpro domain IPR002110 (Ankyrin)
48	K08D10.11	K08D10.11	n/a	chrIV 4,185,528
49	C24G7.1	C24G7.1	n/a	chrI 4,110,897	contains similarity to Pfam domain PF00858 Amiloride-sensitive sodium channel contains similarity to Interpro domain IPR001873 (Na+ channel, amiloride-sensitive)
50	C08H9.11	C08H9.11	n/a	chrII 9,858,792	contains similarity to Pfam domain PF00704 Glycosyl hydrolases family 18 contains similarity to Interpro domains IPR011583 (Chitinase II), IPR017853 (Glycoside hydrolase, catalytic core), IPR001223 (Glycoside hydrolase, family 18, catalytic domain), IPR013781 (Glycoside hydrolase, subgroup, catalytic core)