UCSC C. elegans Gene Sorter

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UCSC C. elegans Gene Sorter

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#	Name	WormBase	BLASTP E-Value	Genome Position	Description
1	W04A8.6	W04A8.6	0	chrI 13,856,302	contains similarity to Interpro domain IPR011598 (Helix-loop-helix DNA-binding)
2	T24C4.5	T24C4.5	n/a	chrIII 878,584	contains similarity to Pfam domain PF01896 Eukaryotic and archaeal DNA primase small subunit contains similarity to Interpro domains IPR014052 (DNA primase, small subunit, eukaryotic and archaeal), IPR002755 (DNA primase, small subunit)
3	C41D11.5	C41D11.5	n/a	chrI 4,450,433
4	pri-1	F58A4.4	n/a	chrIII 9,613,184	pri-1 encodes a homolog of the DNA polymerase alpha-primase subunit D that is required in embryos for the normal timing of embryonic cell divisions, much as DIV-1 is.
5	C25A1.1	C25A1.1	n/a	chrI 10,162,948	contains similarity to Danio rerio Novel protein (Zgc:65774).; TR:Q1LX81
6	C17H11.4	C17H11.4	n/a	chrX 8,181,277	contains similarity to Drosophila melanogaster Flybase gene name is ari-1-PC;; FLYBASE:CG5659
7	C17F4.5	C17F4.5	n/a	chrII 3,247,215	This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins.
8	B0511.7	B0511.7	n/a	chrI 10,632,437	contains similarity to Pfam domain PF00498 FHA domain contains similarity to Interpro domains IPR008984 (SMAD/FHA domain), IPR000253 (Forkhead-associated)
9	C50B6.3	C50B6.3	n/a	chrV 13,314,685	contains similarity to Pfam domain PF02408 CUB-like domain contains similarity to Interpro domain IPR003366 (CUB-like region)
10	fsn-1	C26E6.5	n/a	chrIII 4,938,358	This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins
11	C29A12.1	C29A12.1	n/a	chrV 10,812,876	contains similarity to Mesocricetus auratus Synaptonemal complex protein 1 (SCP-1 protein) (Meiotic chromosomessynaptic protein) (Fragment).; SW:SCP1_MESAU
12	sra-25	T26E3.9	n/a	chrI 12,687,150	C. elegans SRA-25 protein; contains similarity to Pfam domain PF02117 C.elegans Sra family integral membrane protein contains similarity to Interpro domains IPR003945 (NADH-plastoquinone oxidoreductase, chain 5), IPR000344 (Nematode chemoreceptor, Sra)
13	polh-1	F53A3.2	n/a	chrIII 1,947,677	polh-1 encodes a putative DNA polymerase eta orthologous to human POLH (OMIM:603968, mutated in xeroderma pigmentosum); POLH-1 promotes lagging-strand synthesis through G/C rich sequences, is required for normal resistance to UV-induced mutagenesis in early embryos, and suppresses the damage-induced DNA replication checkpoint in embryos; polh-1(RNAi) enhances the mutator phenotype of dog-1(gk10) 2.3-fold.
14	F43D2.1	F43D2.1	n/a	chrV 14,613,051	contains similarity to Pfam domain PF00134 Cyclin, N-terminal domain contains similarity to Interpro domains IPR006670 (Cyclin), IPR011028 (Cyclin-like), IPR013763 (Cyclin-related), IPR006671 (Cyclin, N-terminal), IPR015429 (Transcription regulator cyclin)
15	C08F8.3	C08F8.3	n/a	chrIV 11,155,803	contains similarity to Gallus gallus Dosal neuron-tube nuclear protein.; TR:Q8QHJ7
16	T03F6.3	T03F6.3	n/a	chrIII 13,390,012	contains similarity to Pfam domain PF01182 Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase contains similarity to Interpro domains IPR006148 (Glucosamine/galactosamine-6-phosphate isomerase), IPR004547 (Glucosamine-6-phosphate isomerase)
17	pch-2	F10B5.5	n/a	chrII 8,159,065	pch-2 encodes a putative AAA+-type ATPase orthologous to budding yeast PCH2 and human TRIP13 (OMIM:604507); PCH-2 is required for the apoptosis of pachytene cells induced by unsynapsed chromosomal pairing centers, but is dispensable for meiotic apoptosis induced by DNA damage; PCH-2-mediated apoptosis is inhibited by SYP-1 and SYP-2, while it requires HIM-8 (and probably HIM-8's paralogs, ZIM-1/-3 and C02F5.12); however, PCH-2-mediated apoptosis does not require SPO-11; pch-2 transcripts are enriched during oogenesis; the excess germline apoptosis of syp-1(me17) mutants is partially suppressed by pch-2(tm1458), and fully suppressed by pch-2(tm1458);spo-11(ok79).
18	W01A8.5	W01A8.5	n/a	chrI 7,070,051	contains similarity to Interpro domain IPR009057 (Homeodomain-like)
19	R11H6.5	R11H6.5	n/a	chrV 14,611,457	contains similarity to Pfam domain PF07528 DZF contains similarity to Interpro domains IPR006561 (DZF), IPR006116 (2-5-oligoadenylate synthetase, ubiquitin-like region)
20	set-17	T21B10.5	n/a	chrII 8,939,689	set-17 encodes a SET domain-containing protein orthologous to human PRDM11 and PRDM7 (Q9NQW5-2; OMIM:609759); SET-17 is expressed in many or all cells of embryo, and several postembryonic tissues (hypodermis, muscle, and excretory cell); neither set-17(n5017) nor set-17(RNAi) have any obvious phenotypes.
21	pie-1	Y49E10.14	n/a	chrIII 12,427,870	pie-1 encodes a C-x8-C-x5-C-x3-H-type zinc-finger protein; maternally provided PIE-1 is essential for germline cell fate determination, as it functions as a repressor of RNA polymerase II-dependent gene expression in the developing germ line; PIE-1 localization, initially uniform and then concentrated in the posterior germ cell lineages, is regulated by other maternally supplied gene products including PAR-1, MEX-5, and MEX-6.
22	K08F9.4	K08F9.4	n/a	chrV 15,145,223	contains similarity to Saccharomyces cerevisiae Essential protein with a highly acidic N-terminal domain; IFH1 exhibits genetic interactions with FHL1, overexpression interferes with silencing at telomeres and HM loci; potential Cdc28p substrate; SGD:YLR223C
23	dsh-2	C27A2.6	n/a	chrII 5,079,682	dsh-2 encodes a protein containing a DIX domain, a DEP domain, and a PDZ domain that is required for embryonic viability and functions in Wnt pathway signaling between the embryonic blastomeres P2 and EMS with respect to endoderm specification and to orient the division axis of the EMS cell; expressed from the four-cell embryo stage, and is primarily associated with membranes.
24	tag-146	C27A12.3	n/a	chrI 6,039,839	C. elegans TAG-146 protein; contains similarity to Pfam domain PF00096 Zinc finger, C2H2 type contains similarity to Interpro domains IPR015880 (Zinc finger, C2H2-like), IPR007086 (Zinc finger, C2H2-subtype), IPR013087 (Zinc finger, C2H2-type/integrase, DNA-binding), IPR007087 (Zinc finger, C2H2-type)
25	F10G2.2	F10G2.2	n/a	chrV 7,331,479
26	R10D12.12	R10D12.12	n/a	chrV 13,961,624	contains similarity to Pfam domain PF04101 Glycosyltransferase family 28 C-terminal domain contains similarity to Interpro domain IPR007235 (Glycosyl transferase, family 28, C-terminal)
27	W04D2.4	W04D2.4	n/a	chrV 12,496,219	contains similarity to Interpro domains IPR015880 (Zinc finger, C2H2-like), IPR007087 (Zinc finger, C2H2-type)
28	C35D10.10	C35D10.10	n/a	chrIII 4,861,200	contains similarity to Pfam domain PF00085 Thioredoxin contains similarity to Interpro domains IPR012336 (Thioredoxin-like fold), IPR012335 (Thioredoxin fold), IPR013766 (Thioredoxin domain)
29	F30A10.3	F30A10.3	n/a	chrI 9,493,712	contains similarity to Pfam domain PF03770 Inositol polyphosphate kinase contains similarity to Interpro domain IPR005522 (Inositol polyphosphate kinase)
30	F11C1.2	F11C1.2	n/a	chrX 12,986,446	contains similarity to Lactococcus lactis Rgg protein, putative.; TR:O87251
31	adbp-1	VW02B12L.4	n/a	chrII 11,444,624	C. elegans ADBP-1 protein ;
32	skr-9	C52D10.7	n/a	chrIV 17,163,837	skr-9 encodes a homolog of Skp1 in S. cerevisiae, a component of the SCF (Skp1, Cullin, F-box) ubiquitin-ligase complex that regulates ubiquitin-mediated protein degradation; SKR-9 is required for posterior body morphogenesis, embryonic and larval development, and postembryonic cell proliferation.
33	C32B5.10	C32B5.10	n/a	chrII 947,356
34	hcp-3	F58A4.3	n/a	chrIII 9,615,787	The hcp-3 gene encodes a centromere protein (CENP)-A homolog required for kinetochore function; inactivation of hcp-3 in one-cell embryos by RNAi causes a complete loss of kinetochores, with total failure of chromosomes to segregate properly during mitosis, to recruit components to the kinetochore other than HCP-3, or to assemble a stable mitotic spindle; in addition, HCP-4 fails to localize properly to the kinetochore in hcp-3(RNAi) embryos.
35	T05B11.4	T05B11.4	n/a	chrV 7,753,022	contains similarity to Pfam domain PF01697 Domain of unknown function contains similarity to Interpro domain IPR008166 (Protein of unknown function DUF23)
36	F41G3.6	F41G3.6	n/a	chrII 6,743,499
37	gei-6	C05C8.4	n/a	chrV 7,228,595	C. elegans GEI-6 protein; contains similarity to Interpro domain IPR000694 (Proline-rich region)
38	F55C5.4	F55C5.4	n/a	chrV 12,273,750	contains similarity to Pfam domain PF02985 HEAT repeat contains similarity to Interpro domain IPR016024 (Armadillo-type fold)
39	him-10	R12B2.4	n/a	chrIII 5,804,132	him-10 encodes a coiled coil protein that is structurally related to the Nuf2 kinetochore proteins of Schizosaccharaomyces pombe, Saccharomyces cerevisiae, and humans; in C. elegans, him-10 activity is essential for the proper structure and function of mitotic and meiotic kinetochores and thus, for proper attachment and segregation of chromosomes during mitosis and meiosis; during mitosis, HIM-10 localizes to the kinetochore region of the kinetochore-centromere complex from prophase to anaphase; during oocytes meiosis, HIM-10 surrounds chromosomes in diakinesis and prometaphase of meiosis I and meiosis II, while during male meiosis, HIM-10 surrounds spermatocyte chromosomes during metaphase I, anaphase I, and metaphase II.
40	F17C11.10	F17C11.10	n/a	chrV 10,963,667	contains similarity to Pfam domain PF00400 WD domain, G-beta repeat contains similarity to Interpro domains IPR011046 (WD40 repeat-like), IPR009071 (High mobility group box, HMG), IPR001680 (WD40 repeat), IPR015943 (WD40/YVTN repeat-like)
41	spe-42	B0240.2	n/a	chrV 11,735,328	C. elegans SPE-42 protein; contains similarity to Pfam domain PF07782 DC-STAMP-like protein contains similarity to Interpro domain IPR012858 (DC-STAMP-like)
42	nasp-2	C50B6.2	n/a	chrV 13,311,278	C. elegans NASP-2 protein ; contains similarity to Halocynthia roretzi Protein HGV2.; SW:Q02508
43	Y5F2A.4	Y5F2A.4	n/a	chrIV 11,077,311	contains similarity to Pfam domain PF00096 Zinc finger, C2H2 type contains similarity to Interpro domains IPR015880 (Zinc finger, C2H2-like), IPR013087 (Zinc finger, C2H2-type/integrase, DNA-binding), IPR007087 (Zinc finger, C2H2-type)
44	efn-3	F15A2.5	n/a	chrX 13,476,463	efn-3 encodes a potential GPI-modified ephrin that is, with EFN-2, is required for normal epidermal organization in the male tail; EFN-3, along with EFN-1 and EFN-2, activates the VAB-1 tyrosine kinase in vivo and binds it in vitro, and has a minor role in embryonic epiboly.
45	brc-1	C36A4.8	n/a	chrIII 3,858,030	brc-1 encodes an ortholog of human BRCA1 (OMIM:113705, mutated in early onset breast and ovarian cancer) required for double-strand break repair via inter-sister recombination during meiosis; BRC-1 forms a heterodimer with BRD-1, which constitutes an E3 ubiquitin ligase; after irradiation, the DNA checkpoint proteins ATL-1 and MRE-11 are required for BRC-1/BRD-1 heterodimers to associate with RAD-51 and LET-70/Ubc5, and to ubiquitylate damaged chromatin; brc-1(RNAi) animals have excess chromosomal nondisjunction, abnormally high levels of CEP-1-dependent germ cell apoptosis (both with and without gamma-irradiation) and hypersensitivity to gamma-irradiation (e.g., abnormal sterility after irradiation); BRC-1 and BRD-1 bind one another, probably through their N-terminal RING domains, in yeast two-hybrid experiments and pull-down assays; BRC-1/BRD-1 heterodimers may interact with RAD-51 and other proteins via mutual binding to UBC-9; brc-1 is genetically dispensable for the induction of nuclear ATL-1 foci by gamma-irradiation or hydroxyurea.
46	mom-5	T23D8.1	n/a	chrI 9,967,489	mom-5 encodes one of four C. elegans members of the Frizzled (Fz) family of seven transmembrane receptors; during development, MOM-5 activity is required for asymmetric cell division in the early embryo as well as for asymmetric cell division during neuronal development; MOM-5::GFP is enriched at the posterior pole of cells prior to division and during later stages of embryogenesis, is found at the leading edges of epidermal cells during ventral enclosure; in neuroblasts, MOM-5 is required for proper subcellular distribution of DSH-2 to the cortex.
47	Y4C6B.1	Y4C6B.1	n/a	chrIV 5,355,504	contains similarity to Interpro domain IPR000694 (Proline-rich region)
48	F59E12.11	F59E12.11	n/a	chrII 5,648,707	contains similarity to Homo sapiens Isoform 1 of Loss of heterozygosity 12 chromosomal region 1 protein; ENSEMBL:ENSP00000321546
49	pfd-4	B0035.4	n/a	chrIV 11,315,430	pfd-4 encodes a putative prefoldin subunit 4, orthologous to human PFDN4 (OMIM:604898), that is dispensable for viability; PFD-4 is redundant for prefoldin function in C. elegans; pfd-4(gk403) mutants and pfd-4(RNAi) animals, unlike animals undergoing RNAi against most prefoldin subunits, have no obvious phenotypes.
50	agt-2	F09E5.13	n/a	chrII 5,372,696	agt-2 encodes a paralog of the DNA repair enzyme O6-Alkylguanine DNA-alkyltransferase (AGT); AGT-2 has AGT biochemical activity and is expressed at all developmental stages.