UCSC C. elegans Gene Sorter

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UCSC C. elegans Gene Sorter

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#	Name	WormBase	BLASTP E-Value	Genome Position	Description
1	tsp-9	C25G6.2	6e-99	chrX 1,246,754	C. elegans TSP-9 protein; contains similarity to Pfam domain PF00335 Tetraspanin family contains similarity to Interpro domains IPR000301 (CD9/CD37/CD63 antigen), IPR008952 (Tetraspanin)
2	M28.1	M28.1	n/a	chrII 10,624,279	contains similarity to Pfam domain PF00100 Zona pellucida-like domain contains similarity to Interpro domain IPR001507 (Endoglin/CD105 antigen)
3	nhr-67	C08F8.8	n/a	chrIV 11,172,266	nhr-67 encodes a nuclear receptor that is orthologous to Drosophila and vertebrate tailless hormone receptors; during development, nhr-67 plays an essential role in larval development and also functions as part of a complex regulatory network that regulates vulval patterning and differentiation and thus, egg laying; specifically, nhr-67 functions to positively regulate gene expression in the vulA, vulD, and vulF cells and negatively regulate gene expression in vulE and vulF; in regulating vulval gene expression, nhr-67 functions together with other transcription factors, including egl-38, lin-11, and cog-1; nhr-67 reporter fusion constructs are expressed dynamically in multiple vulval cell types as well as in head neurons, the hyp7 syncytium, late-stage embryos, the male tail, the anchor cell, and the linker cell.
4	F46F5.14	F46F5.14	n/a	chrII 800,774	contains similarity to Pfam domain PF03314 Protein of unknown function, DUF273 contains similarity to Interpro domain IPR004988 (Protein of unknown function DUF273)
5	H19J13.1	H19J13.1	n/a	chrX 12,268,942	contains similarity to Pfam domain PF03189 Protein of unknown function, DUF270 contains similarity to Interpro domain IPR004878 (Protein of unknown function DUF270)
6	F59D12.2	F59D12.2	n/a	chrX 15,674,207	contains similarity to Homo sapiens Calcium-dependent protease, small subunit; ENSEMBL:ENSP00000246533
7	sop-2	C50E10.4	n/a	chrII 12,342,269	sop-2 encodes a SAM domain-containing protein that is related to, but not orthologous with, Polycomb group proteins and ETS transcription factors; during development, SOP-2 activity is required for maintaining a restricted pattern of Hox gene expression, such as that of mab-5 and egl-5, to specific cells and tissues; thus, SOP-2 is required for proper cell fate specification in a variety of cell lineages, including the serotonergic and dopaminergic male tail neurons and the ventral nerve cord; in regulating neurotransmitter phenotype, sop-2 functions together with sor-3, which also encodes a Polycomb group protein, and members of the TGF-beta signaling pathway; sop-2 and sor-3 also function together to regulate progression through larval development; a SOP-2::GFP reporter fusion is expressed in the nuclei of all somatic cells beginning at the 50-cell stage of embryogenesis; SOP-2::GFP expression is initially diffuse, but by the 200-cell stage is visible in distinct nuclear bodies, the size and number of which may correlate with DNA content.
8	mec-6	W02D3.3	n/a	chrI 6,726,624	mec-6 is homologous to the human PARAOXONASE 1 gene (PON1, OMIM:168820), which in some allelic forms is associated with susceptibility to coronary artery disease; MEC-6 protein interacts physically with the MEC-4 degenerin ion channel, is colocalized with it in vivo, and is required for MEC-4 punctate expression along touch-receptor neural processes.
9	F47G4.5	F47G4.5	n/a	chrI 14,061,493	F47G4.5 encodes a paralog of MEI-2 that, like MEI-2, binds MEI-1 in vitro; F47G4.5 might thus be an alternative ligand of MEI-1 in vivo.
10	ZC190.6	ZC190.6	n/a	chrV 8,675,924
11	K04G11.4	K04G11.4	n/a	chrX 14,351,065	contains similarity to Pfam domain PF00400 WD domain, G-beta repeat contains similarity to Interpro domains IPR011046 (WD40 repeat-like), IPR000694 (Proline-rich region), IPR001680 (WD40 repeat), IPR011042 (Six-bladed beta-propeller, TolB-like), IPR001632 (G-protein, beta subunit), IPR015943 (WD40/YVTN repeat-like)
12	F46G11.1	F46G11.1	n/a	chrX 5,794,401	F46G11.1 is orthologous to the human gene TRUNCATED PUTATIVE T7-LIKE MITOCHONDRIAL DNA HELICASE (C10orf2; OMIM:606075), which when mutated leads to disease.
13	ceh-13	R13A5.5	n/a	chrIII 7,556,858	a homolog of Hox genes of labial/Hox1 type; affects viability, body shape and anterior patterning during embryogenesis, interacts genetically with hox genes; and is expressed in A, D, E and MS lineages in the early embryo, and in the anterior dorsal hypodermal cells, anterior body wall muscle cells, and in the cells of the prospective ventral nerve cord at the comma stage; and in the ventral nerve cord and and ventral and dorsal hypodermal cells in L1 larvae.
14	C17E4.11	C17E4.11	n/a	chrI 9,420,385	contains similarity to Pfam domain PF08241 Methyltransferase domain contains similarity to Interpro domain IPR013216 (Methyltransferase type 11)
15	ceh-37	C37E2.5	n/a	chrX 14,203,216	ceh-37 encodes one of three C. elegans proteins with an OTX-like homeodomain; however, CEH-37 lacks other domains found in OTX proteins, and the CEH-37 homeodomain is predicted to resemble the Myb domain of telomere-binding proteins; CEH-37 binds the telomeric sequence 'TTAGGC' if it is repeated at least 1.5 times, and is mainly localized to the telomere in vivo; ceh-37 mutants have a weak increase in chromosomal nondisjunction; CEH-37 is involved in specifying some aspects of the AWB olfactory neuron fate, such as expression of an AWB-specific odorant receptor and a LIM-class homeodomain protein, LIM-4; CEH-37 is expressed broadly in the early embryo, while in larvae and adults it is expressed solely in the excretory cell.
16	atf-2	K08F8.2	n/a	chrII 8,752,891	C. elegans ATF-2 protein; contains similarity to Pfam domains PF07716 (Basic region leucine zipper) (2), PF00170 (bZIP transcription factor) contains similarity to Interpro domains IPR011700 (Basic leucine zipper), IPR004827 (Basic-leucine zipper (bZIP) transcription factor), IPR011616 (bZIP transcription factor, bZIP-1)
17	col-56	T08B2.2	n/a	chrI 6,233,530	C. elegans COL-56 protein; contains similarity to Pfam domain PF01391 Collagen triple helix repeat (20 copies) contains similarity to Interpro domains IPR000694 (Proline-rich region), IPR008160 (Collagen triple helix repeat)
18	K02E10.1	K02E10.1	n/a	chrX 2,498,552	contains similarity to Pfam domains PF00071 (Ras family) , PF08477 (Miro-like protein) contains similarity to Interpro domains IPR002041 (Ran GTPase), IPR003577 (Ras small GTPase, Ras type), IPR013684 (Miro-like), IPR003578 (Ras small GTPase, Rho type), IPR005225 (Small GTP-binding protein), IPR001806 (Ras GTPase), IPR003579 (Ras small GTPase, Rab type), IPR006688 (ADP-ribosylation factor), IPR013753 (Ras)
19	srx-97	F19B10.7	n/a	chrII 3,667,915	C. elegans SRX-97 protein; contains similarity to Pfam domain PF01748 Caenorhabditis serpentine receptor-like protein contains similarity to Interpro domain IPR002651 (Protein of unknown function DUF32)
20	coh-1	K08A8.3	n/a	chrX 7,470,222	coh-1 encodes a RAD21 homolog that affects embryonic viability and is believed to affect cohesion of sister chromatids in somatic cells; expressed in the distal tip cells of the gonad, embryonic, and somatic cells
21	F53A2.1	F53A2.1	n/a	chrIII 13,321,932	contains similarity to Pfam domain PF06542 Protein of unknown function (DUF1114) contains similarity to Interpro domains IPR001810 (Cyclin-like F-box), IPR009497 (Protein of unknown function DUF1114), IPR009010 (Aspartate decarboxylase-like fold)
22	F42H10.3	F42H10.3	n/a	chrIII 8,486,094	contains similarity to Pfam domains PF07653 (Variant SH3 domain) , PF00018 (SH3 domain) , PF00880 (Nebulin repeat) (2), PF00412 (LIM domain) contains similarity to Interpro domains IPR000900 (Nebulin 35 residue motif), IPR013998 (Nebulin), IPR001452 (Src homology-3), IPR000108 (Neutrophil cytosol factor 2), IPR011511 (Variant SH3), IPR001781 (Zinc finger, LIM-type)
23	C27A7.2	C27A7.2	n/a	chrV 12,139,241	contains similarity to Pfam domain PF01697 Domain of unknown function contains similarity to Interpro domains IPR008167 (Protein of unknown function DUF23, C-terminal), IPR008166 (Protein of unknown function DUF23)
24	lin-33	H32C10.2	n/a	chrIV 5,931,939	C. elegans LIN-33 protein; contains similarity to Interpro domain IPR002873 (Non-structural protein NSP3, Rotavirus)
25	unc-24	F57H12.2	n/a	chrIV 7,980,963	unc-24 encodes a protein that contains a stomatin-like domain and a lipid transfer domain; unc-24 activity is essential for normal locomotion and for wild-type sensitivity to lipid-soluble volatile anesthetics; unc-24 is genetically epistatic to unc-79 and to unc-1, which encodes an additional stomatin whose stability and localization to the nerve ring are dependent upon UNC-24; unc-24 is expressed in the touch receptor neurons as well as neurons in the ventral cord.
26	C43H6.3	C43H6.3	n/a	chrX 2,408,512	contains similarity to Pfam domain PF00023 Ankyrin repeat contains similarity to Interpro domain IPR002110 (Ankyrin)
27	F38B6.1	F38B6.1	n/a	chrX 6,700,523
28	Y45F10B.12	Y45F10B.12	n/a	chrIV 13,587,824	contains similarity to Pfam domain PF07735 F-box associated contains similarity to Interpro domain IPR012885 (F-box associated type 2)
29	srw-67	F18E3.2	n/a	chrV 7,418,725	C. elegans SRW-67 protein; contains similarity to Interpro domain IPR017452 (GPCR, rhodopsin-like superfamily)
30	dnj-14	K02G10.8	n/a	chrX 4,710,717	This gene encodes a protein containing a DnaJ ('J') domain.
31	F59B10.3	F59B10.3	n/a	chrII 10,511,687	contains similarity to Interpro domain IPR016196 (MFS general substrate transporter)
32	F58F6.5	F58F6.5	n/a	chrIV 1,343,974	contains similarity to Pfam domain PF04789 Protein of unknown function (DUF621) contains similarity to Interpro domain IPR006874 (Protein of unknown function DUF621)
33	nhr-204	R02C2.4	n/a	chrV 256,479	C. elegans NHR-204 protein; contains similarity to Pfam domains PF00104 (Ligand-binding domain of nuclear hormone receptor) , PF00105 (Zinc finger, C4 type (two domains)) contains similarity to Interpro domains IPR008946 (Nuclear hormone receptor, ligand-binding), IPR001723 (Steroid hormone receptor), IPR000324 (Vitamin D receptor), IPR013088 (Zinc finger, NHR/GATA-type), IPR001628 (Zinc finger, nuclear hormone receptor-type), IPR000536 (Nuclear hormone receptor, ligand-binding, core)
34	nhr-207	R07B7.14	n/a	chrV 12,097,016	C. elegans NHR-207 protein; contains similarity to Pfam domains PF00104 (Ligand-binding domain of nuclear hormone receptor) , PF00105 (Zinc finger, C4 type (two domains)) contains similarity to Interpro domains IPR008946 (Nuclear hormone receptor, ligand-binding), IPR001723 (Steroid hormone receptor), IPR001728 (Thyroid hormone receptor), IPR000324 (Vitamin D receptor), IPR013088 (Zinc finger, NHR/GATA-type), IPR001628 (Zinc finger, nuclear hormone receptor-type), IPR000536 (Nuclear hormone receptor, ligand-binding, core)
35	pqn-26	DY3.5	n/a	chrI 8,774,608	The protein product of this gene is predicted to contain a glutamine/asparagine (Q/N)-rich ('prion') domain, by the algorithm of Michelitsch and Weissman (as of the WS77 release of WormBase, i.e., in wormpep77).
36	egl-18	F55A8.1	n/a	chrIV 1,915,415	egl-18 encodes a member of the GATA-family of transcription factors that affects cell migration, cell fate specification; expressed in the head, in hypodermal seam cells, VC neurons, and vulval precursor cells.
37	ZK829.1	ZK829.1	n/a	chrIV 11,941,464	contains similarity to Pfam domain PF00106 short chain dehydrogenase contains similarity to Interpro domains IPR002424 (Insect alcohol dehydrogenase family), IPR003560 (2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase), IPR002347 (Glucose/ribitol dehydrogenase), IPR002198 (Short-chain dehydrogenase/reductase SDR), IPR016040 (NAD(P)-binding)
38	inx-6	C36H8.2	n/a	chrIV 12,748,113	inx-6 encodes an innexin, an integral transmembrane channel protein that is a structural component of invertebrate gap junctions; INX-6 is required for formation of pharyngeal gap junctions and thus for the electrical coupling and synchronous muscle contractions necessary for normal feeding behavior and postembryonic development; INX-6 may function redundantly with EAT-5, another C. elegans innexin; INX-6 expression is first detected in embryonic pharyngeal precursors and during later larval and adult stages, in pharyngeal corpus muscles and isthmus marginal cells, where INX-6 localizes to plaque-like structures in the plasma membrane.
39	T15B7.8	T15B7.8	n/a	chrV 6,822,465	contains similarity to Ostreococcus tauri Predicted CDS, putative cytoplasmic protein family member, with ascoiled coil-4 domain, of ancient origin (ISS).; TR:Q010X5
40	T23G5.6	T23G5.6	n/a	chrIII 9,241,340	contains similarity to Pfam domain PF02178 AT hook motif contains similarity to Interpro domain IPR000637 (HMG-I and HMG-Y, DNA-binding)
41	clc-2	C01C10.1	n/a	chrX 7,432,451	clc-2 encodes a claudin homolog, closely similar to CLC-1, that is required for normal cohesion of apical junctions in epithelia; claudins are integral membrane proteins with four transmembrane sequences that are found in mammalian tight junctions (TJs), induce TJs when transgenically expressed in cells normally lacking them, and can mediate the specific conductance of of specific ions (e.g., magnesium or calcium) through TJs while blocking the flow of water; CLC-2 maintains the impermeability ('barrier function') of epithelia, since clc-1(RNAi) animals have abnormal permeability of the hypodermis to dyes; clc-2 is expressed in hypodermal seam cells, with two diffuse lines of CLC-2 protein.
42	C45G7.4	C45G7.4	n/a	chrIV 2,434,709	contains similarity to Pfam domain PF00097 Zinc finger, C3HC4 type (RING finger) contains similarity to Interpro domains IPR001841 (Zinc finger, RING-type), IPR013083 (Zinc finger, RING/FYVE/PHD-type)
43	C45B11.2	C45B11.2	n/a	chrV 11,043,313	contains similarity to Pfam domain PF06441 ()
44	ZC190.5	ZC190.5	n/a	chrV 8,672,433
45	F21D5.9	F21D5.9	n/a	chrIV 8,724,343	contains similarity to Interpro domains IPR015880 (Zinc finger, C2H2-like), IPR007087 (Zinc finger, C2H2-type)
46	R08C7.1	R08C7.1	n/a	chrIV 4,451,940
47	Y7A5A.2	Y7A5A.2	n/a	chrX 15,772,148	contains similarity to Aquifex aeolicus Hypothetical protein AQ_372.; SW:Y372_AQUAE
48	T01A4.3	T01A4.3	n/a	chrI 4,465,379	contains similarity to Pfam domain PF06918 Protein of unknown function (DUF1280) contains similarity to Interpro domain IPR009689 (Protein of unknown function DUF1280)
49	T28F12.1	T28F12.1	n/a	chrV 4,514,448
50	lgc-55	Y113G7A.5	n/a	chrV 20,025,213	C. elegans LGC-55 protein; contains similarity to Pfam domains PF02931 (Neurotransmitter-gated ion-channel ligand binding domain) , PF02932 (Neurotransmitter-gated ion-channel transmembrane region) contains similarity to Interpro domains IPR002289 (Gamma-aminobutyric-acid A receptor, beta subunit), IPR006028 (Gamma-aminobutyric acid A receptor), IPR006201 (Neurotransmitter-gated ion-channel), IPR013032 (EGF-like region, conserved site), IPR006202 (Neurotransmitter-gated ion-channel ligand-binding), IPR006029 (Neurotransmitter-gated ion-channel transmembrane region)