Gene interactions and pathways from curated databases and text-mining

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PRKDC — XRCC5

Pathways - manually collected, often from reviews:

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

Text-mined interactions from Literome

Abraham et al., Oncogene 1999 : Recent studies have indicated that DNA-PK is not required for the transactivation or apoptosis promoting activities of p53 protein
Kachnic et al., J Biol Chem 1999 : Taken together, these data suggest that loss of DNA-PK activity appears to attenuate the kinetics of p53 to activate downstream genes, implying that DNA-PK plays a role in post-translational modification of p53 , without affecting the increase in levels of p53 in response to DNA damage
Araki et al., Cancer Res 1999 (Mammary Neoplasms, Experimental) : Furthermore, we identified a missense point mutation in the p53 DNA binding motif region in SCGR11 cells, which were established from severe combined immunodeficient ( SCID ) mice and used for previous study on the role of DNA-PK in p53 transactivation
Ariumi et al., Oncogene 1999 : Thus, DNA-PK suppresses PARP activity, probably through direct binding and/or sequestration of DNA-ends which serve as an important stimulator for both enzymes
Iftode et al., Crit Rev Biochem Mol Biol 1999 : RPA is a phosphorylation target for DNA dependent protein kinase (DNA-PK) and likely the ataxia telangiectasia mutated gene (ATM) protein kinase, and recent observations are described that suggest that RPA phosphorylation plays a significant modulatory role in the cellular response to DNA damage
Lin et al., Mol Immunol 1999 : These data raise the possibility that DNA-PK mediated phosphorylation of the RAG proteins could regulate the hairpin opening reaction
Brown et al., J Biol Chem 2000 : Further, we uncovered that the postirradiation up-regulation of Ku70 utilizes a mechanism that is dependent on both p53 and damage response protein kinase ATM ( ataxia-telangiectasia mutated ) ; however, the activation of DNA-PK does not require Ku70 up-regulation
Shangary et al., J Biol Chem 2000 (Ataxia Telangiectasia) : To unravel the role of ATM and DNA-PK in the activation of Abl , we assayed Abl, ATM, and DNA-PK activity in ATM- and DNA-PKcs-deficient cells after irradiation ... Conversely, normal activation of both ATM and c-Abl occurs in DNA-PKcs-deficient cells, indicating that ATM but not DNA-PK is required for activation of Abl in response to IR treatment ... Examination of DNA-PK activity in response to IR treatment in Abl-deficient cells expressing mutant forms of Abl or in normal cells exposed to an inhibitor of Abl suggests an in vivo role for Abl in the down-regulation of DNA-PK activity
Sook Kim et al., Biochem Biophys Res Commun 2001 (Liver Neoplasms...) : In addition, wortmannin, a DNA dependent protein kinase (DNA-PK) inhibitor, decreased the level of hHR21 ( SP ) mRNA, indicating that DNA-PK might be involved in the regulation of hHR21 ( SP )
Bryntesson et al., Radiat Res 2001 : We present evidence that transcription of the extracellular matrix gene laminin alpha 4 (Lama4) is regulated by DNA-PK in a radiation independent manner
Burma et al., J Biol Chem 2001 : The minimal H2AX phosphorylation in Atm-/- fibroblasts can be abolished by low concentrations of wortmannin suggesting that DNA-PK , rather than ATR, is responsible for low levels of H2AX phosphorylation in the absence of ATM
Silins et al., Carcinogenesis 2001 (Liver Neoplasms...) : An inhibitor of DNA dependent protein kinase (DNA-PK) and ataxia telangiectasia mutated (ATM), wortmannin, blocked the DEN induced p53 response in non-EAF hepatocytes
Erdemir et al., J Cell Sci 2002 : The nuclear matrix protein C1D is an activator of the DNA dependent protein kinase (DNA-PK) , which is essential for the repair of DNA double-strand breaks ( DSBs ) and V ( D ) J recombination ... The nuclear matrix protein C1D is an activator of the DNA dependent protein kinase (DNA-PK) , which is essential for the repair of DNA double-strand breaks ( DSBs ) and V ( D ) J recombination
Servant et al., Biochem Pharmacol 2002 (Virus Diseases) : Furthermore, MAP kinase kinase kinase ( MAP KKK ) -related pathways and DNA-PK induce N-terminal phosphorylation of IRF-3
Marples et al., Int J Radiat Biol 2002 : These data support a role for DNA-PK activity in the IRR response
Boldogh et al., Toxicology 2003 (Ovarian Neoplasms) : The decreased kinase activity of DNA-PKcs was not due to a change in its amount or the levels of Ku70 and Ku86, their subcellular distribution, cell cycle progression or caspase mediated degradation of DNA-PK ... The decreased kinase activity of DNA-PKcs was not due to a change in its amount or the levels of Ku70 and Ku86 , their subcellular distribution, cell cycle progression or caspase mediated degradation of DNA-PK ... The decreased kinase activity of DNA-PKcs was not due to a change in its amount or the levels of Ku70 and Ku86, their subcellular distribution, cell cycle progression or caspase mediated degradation of DNA-PK
Schild-Poulter et al., Cancer Res 2003 : Histone H2B and U2 RNA, whose expression are highly dependent on Oct-1, were strongly decreased in response to ionizing radiation in a DNA-PK dependent manner, and Oct-1 dependent reporter gene transcription was repressed ... Furthermore, Oct-1 phosphorylation in response to ionizing radiation increased in a DNA-PK dependent manner ... Paradoxically, down-regulation of transactivation correlated with the rapid DNA-PK dependent stabilization of Oct-1
Jack et al., J Biol Chem 2004 : Using wortmannin, serine 15 mutants of p53, DNA-PK null cells and Chk2 null cells, we demonstrate that DNA-PK and Chk2 act independently and sequentially on p53
Block et al., Nucleic Acids Res 2004 : However, the relative roles of ATM and DNA-PK in the site-specific DNA damage induced phosphorylation of RPA32 have not been reported
Um et al., Exp Mol Med 2004 (Neoplasms) : In this study, we revealed that DNA dependent protein kinase (DNA-PK) , which plays a crucial role in DNA double strand break repair, would be involved in regulation of hypoxia inducible factor-1 (HIF-1)
Veuger et al., Oncogene 2004 : Inactive DNA-PK suppressed the activity of PARP-1 and vice versa ... The inhibitory effect of DNA-PK on PARP activity was confirmed in permeabilized cells
Soubeyrand et al., Eur J Biochem 2004 : Our results suggest a role for DNA-PK in the modulation of p53 activity resultant from the convergence of p53 and DNA-PK on structured DNA
Li et al., J Biol Chem 2005 : Down-regulation of DNA-PK ( cs ) by either siRNA or a chemical inhibitor attenuated radiation induced Chk2 phosphorylation
Dragoi et al., EMBO J 2005 : Further in vitro analysis using purified DNA-PK and recombinant Akt proteins reveals that DNA-PK directly induces phosphorylation and activation of Akt
Vidal et al., Thromb Haemost 2005 : Here, we show that ATM and ATR kinases, but not DNA-PK , which participate in DNA damage activated checkpoints, regulate the phosphorylation of p53 at serine 15 in response to MNNG cell treatment
Douglas et al., DNA repair 2005 : DNA-PK dependent phosphorylation of Ku70/80 is not required for non-homologous end joining ... DNA-PK dependent phosphorylation of Ku70/80 is not required for non-homologous end joining
Dittmann et al., J Biol Chem 2005 : Blockade of EGFR import by the anti-EGFR monoclonal antibody C225 abolished EGFR import into the nucleus and radiation induced activation of DNA-PK , inhibited DNA repair, and increased radiosensitivity of treated cells
Dittmann et al., Radiother Oncol 2005 : Inhibition of radiation induced EGFR nuclear import by C225 ( Cetuximab ) suppresses DNA-PK activity
Cowell et al., Biochem Pharmacol 2005 (Breast Neoplasms) : ATM inhibition reduced the initial average intensity of gammaH2AX foci while inhibition of DNA-PK had only a small effect on the initial phosphorylation of H2AX
Chowdhury et al., Mol Cell 2005 : The effect of PP2A on gamma-H2AX levels is independent of ATM, ATR, or DNA-PK activity
Chin et al., Exp Mol Med 2005 (Neoplasms) : We also revealed that the combined treatment of radiation and the inhibitor of protein kinase A (PKA) to these radioresistant cells resulted in synergistic inhibition of DNA-PK , Rad51 and Bcl-2 expressions of the cells, and consequently restored radiosensitivity of the cells
Friedmann et al., Mol Cancer Ther 2006 (Neoplasms) : In this study, we specifically investigated the effect of EGFR inhibition by gefitinib on functional activity of DNA-PK in cancer cell lines and the interaction between EGFR and DNA-PK
Mukherjee et al., DNA repair 2006 : Interestingly, we find here that DNA dependent protein kinase (DNA-PK) is solely responsible for H2AX phosphorylation during apoptosis while ATM is dispensable for the process
Rossi et al., J Gen Virol 2006 : It was also found that, in cell-free extracts, TCF-4 prevented dsDNA dependent protein kinase (DNA-PK) mediated Sp1 phosphorylation
Rodríguez-Bravo et al., Cancer Res 2006 : Neither wortmannin, Ly294002, nor SB202190 abrogated the caffeine-insensitive checkpoint response, indicating that DNA-PK and p38 alpha, beta are not involved in the ATR/ATM independent Chk1 activation upon DNA synthesis inhibition
Cobb et al., Cancer Res 2006 (Prostatic Neoplasms) : In the absence of DNA-PK activity, IGFBP-3 has reduced nuclear accumulation and is unable to bind its nuclear binding partner retinoid X receptor (RXR) alpha
Zhong et al., Biochemistry 2007 : The indispensable role played by DNA-PK in P-gp overexpression in MDR leukemia cells in this report identifies targeted DNA-PK inhibition as a rational strategy to reverse drug resistance in cancer
Ravi et al., Mol Cell Biochem 2008 (Melanoma) : In addition, our study shows that ATM, but not ATM-Rad3 related (ATR) or DNA dependent protein kinase (DNA-PK) is involved in UV-induced NF-kappaB activation
Liiv et al., Biochim Biophys Acta 2008 : DNA-PK contributes to the phosphorylation of AIRE : importance in transcriptional activity
Wanner et al., Radiother Oncol 2008 : Nuclear EGFR is involved in phosphorylation of DNA-PK at Thr2609, which has a significant impact upon DNA-DSB repair
Müller et al., J Cell Biol 2007 : DNA-PK is activated during replication stress and DNA-PK signaling is enhanced when ATR/ATM signaling is abrogated
Arlander et al., Cancer Res 2008 : Furthermore, in agreement with the checkpoint attenuation, DNA-PK inhibition in ATM-knockdown cells resulted in reduced signaling of the checkpoint kinase CHK1 as evidenced by reduced CHK1 phosphorylation
Bozulic et al., Mol Cell 2008 : PKB activation following DNA damage requires 3-phosphoinositide dependent kinase 1 ( PDK1 ) and DNA dependent protein kinase (DNA-PK)
Boehme et al., Proc Natl Acad Sci U S A 2008 : Correspondingly, down-regulation of DNA-PK prevented phosphorylation of Akt/PKB and GSK-3 after ionizing radiation and strongly reduced the accumulation of p53 ... Correspondingly, down-regulation of DNA-PK prevented phosphorylation of Akt/PKB and GSK-3 after ionizing radiation and strongly reduced the accumulation of p53 ... Correspondingly, down-regulation of DNA-PK prevented phosphorylation of Akt/PKB and GSK-3 after ionizing radiation and strongly reduced the accumulation of p53
Hill et al., DNA repair 2008 : Chromium induced apoptosis therefore involves DNA-PK mediated p53 activation followed by preferential transcription of pro-apoptotic PUMA over anti-apoptotic p21 genes
Guirouilh-Barbat et al., Mol Biol Cell 2008 : In contrast to DNA-PK, ATM phosphorylated H2AX both in NER-proficient and -deficient cells, but its full activation was dependent on H2AX as well as DNA-PK , suggesting a positive feedback loop : DNA-PK-gamma-H2AX-ATM. Knocking-out H2AX or inactivating DNA-PK reduced Et743 's antiproliferative activity, whereas ATM and MRN tended to act as survival factors
Huston et al., Proc Natl Acad Sci U S A 2008 : Intersecting regulatory inputs for cAMP employ EPAC to transduce positive effects, namely the Rap2 dependent nuclear exit and activation of DNA-PK , whereas protein kinase A (PKA) provides the negative input by antagonizing these actions
Surucu et al., J Biol Chem 2008 : However, the physiological role of DNA-PK in the regulation of PKB phosphorylation remains to be established
Dittmann et al., Molecular cancer 2008 : Radiation induced caveolin-1 associated EGFR internalization is linked with nuclear EGFR transport and activation of DNA-PK ... Radiation induced caveolin-1- and EGFR-phosphorylations were associated with nuclear EGFR transport and activation of DNA-PK , as detected by phosphorylation at T2609
Becher et al., J Child Neurol 2008 (Astrocytoma...) : IGFBP2 is overexpressed by pediatric malignant astrocytomas and induces the repair enzyme DNA-PK
Solier et al., Mol Cell Biol 2009 : H2AX phosphorylation was dependent on DNA-PK, while Chk2 phosphorylation was dependent on both ATM and DNA-PK ... H2AX phosphorylation was dependent on DNA-PK , while Chk2 phosphorylation was dependent on both ATM and DNA-PK
Durkin et al., J Biol Chem 2008 : Tax containing nuclear extracts showed increased DNA-PK activity, and specific inhibition of DNA-PK prevented Tax induced activation of Chk2 kinase activity ... We also describe a novel interaction between DNA-PK and Chk2 that requires Tax
Bozulic et al., Curr Opin Cell Biol 2009 (Neoplasms) : This present review concerns PKB regulation by mTORC2 and DNA-PK in a stimulus dependent and context dependent manner and the possible implications of this for PKB activity, substrate specificity and therapeutic intervention
Ting et al., Nucleic Acids Res 2009 : Furthermore, we show that hnRNP A1 is phosphorylated in vivo in a DNA-PK dependent manner and that this phosphorylation is greatly reduced in cell lines which lack hTR
Mannell et al., Cell Signal 2010 : The DNA dependent protein kinase (DNA-PK) , long known for its importance in repairing DNA double strand breaks, belongs to the phosphatidylinositol-3 kinase (PI3-K) super family and has recently been identified as one of the enzymes phosphorylating and activating Akt
Wang et al., Neoplasia (New York, N.Y.) 2009 : Specific disruption of PP2A by either expression of SV40 small tumor antigen or depletion of endogenous PP2A/C by RNA interference inhibits Ku DNA binding and DNA-PK activities, which results in suppression of DNA double-strand break ( DSB ) repair and DNA end joining in association with increased genetic instability ( i.e., chromosomal and chromatid breaks ) ... Overexpression of the PP2A catalytic subunit (PP2A/C) enhances Ku and DNA-PK activities with accelerated DSB repair
Kanungo et al., Mol Cell Biochem 2010 : Exogenously expressed human Ku70 stabilizes Ku80 in Xenopus oocytes and induces heterologous DNA-PK catalytic activity ... Exogenously expressed human Ku70 stabilizes Ku80 in Xenopus oocytes and induces heterologous DNA-PK catalytic activity
Sotiropoulou et al., Nat Cell Biol 2010 : The attenuated p53 activation is the consequence of a faster DNA repair activity, mediated by a higher non-homologous end joining ( NHEJ ) activity, induced by the key protein DNA-PK
Shimura et al., Oncogene 2010 (Neoplasms) : Acquired radioresistance of human tumor cells by DNA-PK/AKT/GSK3beta mediated cyclin D1 overexpression
Zhu et al., PloS one 2010 : Furthermore, we demonstrated that the expression of Cav-1 protected cells against DNA damage through modulating the activities of both the homologous recombination ( HR ) and non-homologous end joining ( NHEJ ) repair systems, as evidenced by the inhibitory effects of the Cav-1 targeted siRNA on cell survival, HR frequency, phosphorylation of DNA dependent protein kinase (DNA-PK) , and nuclear translocation of epidermal growth factor receptor (EGFR) following DNA damage, and by the stimulatory effect of the forced expression of Cav-1 on NHEJ frequency
Zhang et al., Blood 2011 : Moreover, increased AKT ( Ser473 ) phosphorylation was observed in activated B cells, reminiscent of cancers treated with rapamycin, and was reduced by a DNA-pk inhibitor
Zhu et al., Cancer Res 2011 (Cell Transformation, Neoplastic) : RSK2 and DNA-PK , but not ATM or ATR, are required for EGF induced phosphorylation of H2AX at Ser139 ; however, only RSK2 is required for phosphorylation of H2AX at Ser16
Bouquet et al., J Cell Sci 2011 : Importantly, in using either silenced DNA-PK cells or cells exposed to a specific DNA-PK inhibitor ( NU7026 ), we demonstrated that hypoxic DNA-PK activation positively regulates the key transcription factor HIF-1 and one subsequent target gene, GLUT1 ... Importantly, in using either silenced DNA-PK cells or cells exposed to a specific DNA-PK inhibitor ( NU7026 ), we demonstrated that hypoxic DNA-PK activation positively regulates the key transcription factor HIF-1 and one subsequent target gene, GLUT1
Zhao et al., Mol Endocrinol 2011 (Carcinoma, Hepatocellular...) : Herein, we demonstrate that the orphan nuclear receptor TR3 suppresses DSB repair by blocking Ku80 DNA-end binding activity and promoting DNA-PK induced p53 activity in hepatoma cells ... Phosphorylated TR3, in turn, enhances DNA-PK induced phosphorylation and p53 transcription activity, thereby enhancing IR-induced apoptosis in hepatoma cells
Zolner et al., Nucleic Acids Res 2011 : Ionizing radiation ( IR ) -induced phosphorylation of cellular PNKP on S114 was ATM dependent, whereas phosphorylation of PNKP on S126 required both ATM and DNA-PK
Liu et al., Zhonghua lao dong wei sheng zhi ye bing za zhi = Zhonghua laodong weisheng zhiyebing zazhi = Chinese journal of industrial hygiene and occupational diseases 2011 : To study the roles of DNA dependent protein kinase ( DNA-PK ) in silica induced cell cycle changes and expressions of CyclinE and CDK2 in human embryo lung fibroblasts ( HELF )
Stronach et al., Neoplasia (New York, N.Y.) 2011 (Carcinoma...) : DNA-PK mediates AKT activation and apoptosis inhibition in clinically acquired platinum resistance ... Insulin mediated activation of AKT is unaffected by DNA-PK inhibitor treatment, suggesting that this effect is restricted to DNA damage mediated activation of AKT and that, clinically, DNA-PK inhibition might prevent platinum induced AKT activation without interfering with normal glucose homeostasis, an unwanted toxicity of direct AKT inhibitors
Tang et al., Chembiochem 2012 : Our findings show that nuclear and cytoplasmic Abl kinase is activated early on ( within 5 min ) in response to IR by both ATM and DNAPK , and that although one or the other of these kinases is required, either one is sufficient to activate Abl
Furusawa et al., Cancer Lett 2012 (Leukemia) : Inhibition of ataxia-telangiectasia mutated (ATM) or DNA-PK revealed that DNA-PK , rather than ATM, was preferentially involved in Akt phosphorylation and cell survival after US-exposure in all cell lines
Williamson et al., EMBO Mol Med 2012 (Disease Models, Animal...) : In ATM-deficient MCL cells, olaparib induced DNA-PK dependent phosphorylation and stabilization of p53 as well as expression of p53-responsive cell cycle checkpoint regulators, and inhibition of DNA-PK reduced the toxicity of olaparib in ATM-deficient MCL cells
Solier et al., Proc Natl Acad Sci U S A 2012 : We also show that DNA-PK is a client of HSP90a and that HSP90a is required for full DNA-PK activation, ?-H2AX formation, DNA fragmentation, and apoptotic body formation ... We also show that DNA-PK is a client of HSP90a and that HSP90a is required for full DNA-PK activation, ?-H2AX formation, DNA fragmentation, and apoptotic body formation ... In contrast, HSP90 inhibition by geldanamycin markedly enhances TRAIL induced DNA-PK and H2AX activation ... In contrast, HSP90 inhibition by geldanamycin markedly enhances TRAIL induced DNA-PK and H2AX activation
Baritaud et al., Cell death & disease 2012 : AIF mediated caspase independent necroptosis requires ATM and DNA-PK induced histone H2AX Ser139 phosphorylation ... Employing a pharmacological approach and gene knockout cells, we also demonstrate in this paper that the phosphatidylinositol-3-OH kinase related kinases ( PIKKs ) ATM ( ataxia telangiectasia mutated ) and DNA dependent protein kinase (DNA-PK) mediate ?H2AX generation and, consequently, MNNG induced necroptosis ... Further, DNA-PK contributes to H2AX Ser139 phosphorylation
Liu et al., Nucleic Acids Res 2012 : Distinct roles for DNA-PK , ATM and ATR in RPA phosphorylation and checkpoint activation in response to replication stress
Urushihara et al., Biochem Biophys Res Commun 2012 : DNA-PK inhibition causes a low level of H2AX phosphorylation and homologous recombination repair in Medaka ( Oryzias latipes ) cells
Wang et al., Mol Cell Biol 2013 : Thus, centrosomal DNA-PK signaling triggers centrosome overduplication, and this centrosomal event, but not the nuclear DNA damage response, is controlled by SF-1
Ito et al., PloS one 2012 : The results of an in vitro kinase assay showed that BPA inhibited DNA-PK kinase activity in a concentration dependent manner
Ferguson et al., eLife 2012 : DNA-PK has well established functions in the DNA repair and V ( D ) J recombination, hence loss of DNA-PK leads to severe combined immunodeficiency (SCID)
Shimura et al., Cell cycle (Georgetown, Tex.) 2013 : We recently demonstrated that a moderate level of long-term fractionated radiation confers acquired radioresistance to tumor cells, which is caused by DNA-PK/AKT/GSK3ß mediated cyclin D1 overexpression
Li et al., J Biol Chem 2013 : The current study has uncovered a previously unknown mechanism underlying rapamycin induced Akt phosphorylation involving protein phosphatase 2A (PP2A) dependent DNA protein kinase (DNA-PK) activation ... Chemical inhibition of DNA-PK , knockdown or deficiency of DNA-PK catalytic subunit (DNA-PKcs), or knock-out of the DNA-PK component Ku86 inhibited rapamycin induced Akt phosphorylation ... Exposure of cancer cells to rapamycin increased DNA-PK activity, and gene silencing mediated PP2A inhibition attenuated rapamycin induced DNA-PK activity ... Accordingly, simultaneous inhibition of mTOR and DNA-PK did not stimulate Akt activity and synergistically inhibited the growth of cancer cells both in vitro and in vivo
Zhang et al., Invest Ophthalmol Vis Sci 2013 : Our findings suggest Compound 49b induces DNA-PK levels through PKA activity ... DNA-PK is required for Compound 49b induced IGFBP-3 expression, leading to inhibition of REC cell death
Meyer et al., Nucleic Acids Res 2013 : Clustered DNA damage induces pan-nuclear H2AX phosphorylation mediated by ATM and DNA-PK
Calkins et al., Nucleic Acids Res 2013 : Loss of DNA-PK function prevented activation of PARP-1 and its recruitment to chromatin in damaged cells, suggesting regulation of PARP-1 by DNA-PK within a pathway of DNA repair
Brush et al., Proc Natl Acad Sci U S A 1994 : Studies with the simian virus 40 model system indicate that DNA-PK is required for DNA-replication dependent RPA phosphorylation
Watanabe et al., Biochem Biophys Res Commun 1994 : DNA-PK activity determined with a synthetic peptide and alpha-casein as substrates was stimulated several-fold by HMG1 , HMG2, and the DNA binding domains ... DNA-PK activity determined with a synthetic peptide and alpha-casein as substrates was stimulated several-fold by HMG1, HMG2 , and the DNA binding domains ... The stimulation was decreased at higher concentrations of HMG proteins, and DNA-PK activity was inhibited by histone H1
An et al., Biochem Biophys Res Commun 1994 : The ability of p41 to inhibit DNA-PK was largely abolished by heating at 95 degrees C for 30 min
Lees-Miller et al., J Virol 1996 : As ICP0 acts as a promoter independent transactivator of gene expression, these data suggest that ICP0 may function by directly or indirectly targeting the p350/DNA-PKcs subunit of DNA-PK, thereby altering the inhibitory effects of DNA-PK on RNA polymerase II transcription
Kharbanda et al., Nature 1997 : We show that DNA-PK phosphorylates and activates c-Abl in vitro
Chibazakura et al., Eur J Biochem 1997 : These observations suggest that DNA-PK could positively regulate the Pol II basal transcription by phosphorylating TBP and TFIIB
Chen et al., Mutat Res 1997 : Analysis of V3, a hamster equivalent of SCID, indicates that the protein level increases of RAD51 and RAD52 from G0 to G1/S/G2 do not require DNA-PK ... Analysis of V3, a hamster equivalent of SCID, indicates that the protein level increases of RAD51 and RAD52 from G0 to G1/S/G2 do not require DNA-PK
Jin et al., EMBO J 1997 : The propensity for Ku70 to associate with Ku80 and to bind DNA correlates with the ability to activate DNA-PK, although two mutants showed that the roles of Ku70 in DNA-PK activation and IR repair are separate
Mayo et al., Cancer Res 1997 : The data support a model by which DNA-PK activation by DNA damage and phosphorylation of Mdm-2 renders the Mdm-2 protein unable to inhibit p53 transactivation, resulting in cell cycle arrest
Bandyopadhyay et al., J Biol Chem 1998 : Anti-EGFR mAb induced physical interaction between EGFR and DNA-PK or Ku70/80 was dependent on the presence of EGFR, but not on the levels of EGFR ... Our findings demonstrate the existence of a novel cellular pathway in mammalian cells that involves physical interactions between EGFR and DNA-PK or Ku70/80 in response to inhibition of EGFR signaling
Leber et al., J Biol Chem 1998 : Both DNA-PK dependent and independent phosphorylation of XRCC4 in vitro occurs only on serine and threonine residues within the COOH-terminal 130 amino acids, a region of the molecule that is not absolutely required for XRCC4 's DSBR function
Candéias et al., Biochimie 1997 : Thus, our results show that DNA-PK is not the main sensor for genotoxic stress and is not required for p53 activation ... In fact, they rather suggest that DNA-PK may play a role in p53 down-regulation
Kharbanda et al., Oncogene 1998 : The DNA dependent protein kinase (DNA-PK) and the ataxia telangiectasia mutated (ATM) gene product, effectors in the DNA damage response, contribute to the induction of c-Abl activity
Ruscetti et al., J Biol Chem 1998 : The protein kinase activity of DNA-PK can be stimulated by PARP in the presence of NAD+ in a reaction that is blocked by the PARP inhibitor 1, 5-dihydroxyisoquinoline
Basu et al., Biochem Biophys Res Commun 1998 (Glioma) : The role of DNA-PK , a protein kinase involved in the response to DNA damage, in the activation of NF kappa B by IR and TNF alpha was examined ... The role of DNA-PK , a protein kinase involved in the response to DNA damage, in the activation of NF kappa B by IR and TNF alpha was examined ... In HeLa cells, wortmannin, an inhibitor of DNA-PK , blocked the induction of NF kappa B by IR but not by TNF alpha
Woo et al., Nature 1998 : We find that p53 is incapable of binding to DNA in the absence of DNA-PK, that DNA-PK is necessary but not sufficient for activation of p53 sequence-specific DNA binding, and that this activation occurs in response to DNA damage
Yumoto et al., J Biochem 1998 : We previously reported that the activity of DNA-PK in vitro is stimulated by non-histone chromosomal high mobility group proteins (HMG) 1 and 2 comprising two similar repeats, termed domains A and B, and an acidic C-terminal
Kharbanda et al., Oncogene 1998 : c-Abl associates with the DNA dependent protein kinase (DNA-PK) and is activated by DNA-PK dependent phosphorylation