Gene interactions and pathways from curated databases and text-mining

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EIF3B — EIF3E

Pathways - manually collected, often from reviews:

  • Reactome Reaction: EIF3B → EIF3E (direct_complex)

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

Text-mined interactions from Literome

Pilipenko et al., Genes Dev 2000 : Reconstitution of initiation using fully fractionated translation components indicated that 48S complex formation on both IRESs requires eIF2, eIF3 , eIF4A, eIF4B, eIF4F, and the pyrimidine tract binding protein (PTB) but that the FMDV IRES additionally requires ITAF ( 45 ), also known as murine proliferation associated protein ( Mpp1 ), a proliferation dependent protein that is not expressed in murine brain cells
Korneeva et al., J Biol Chem 2000 : Surprisingly, the binding of eIF3 and eIF4A to the central region was mutually cooperative ; eIF3 binding to eIF4G increased 4-fold in the presence of eIF4A, and conversely, eIF4A binding to the central ( but not COOH-terminal ) region of eIF4G increased 2.4-fold in the presence of eIF3 ... Surprisingly, the binding of eIF3 and eIF4A to the central region was mutually cooperative ; eIF3 binding to eIF4G increased 4-fold in the presence of eIF4A, and conversely, eIF4A binding to the central ( but not COOH-terminal ) region of eIF4G increased 2.4-fold in the presence of eIF3 ... Surprisingly, the binding of eIF3 and eIF4A to the central region was mutually cooperative ; eIF3 binding to eIF4G increased 4-fold in the presence of eIF4A, and conversely, eIF4A binding to the central ( but not COOH-terminal ) region of eIF4G increased 2.4-fold in the presence of eIF3
Ling et al., Mol Cell Biol 2002 : The translational function of SLBP genetically required eukaryotic initiation factor 4E (eIF4E), eIF4G, and eIF3 , and expressed SLBP coisolated with S. cerevisiae initiation factor complexes that bound the 5 ' cap in a manner dependent on eIF4G and eIF3
Majumdar et al., J Biol Chem 2003 : The stable association of eIF1 with 40 S subunits required the presence of eIF3 ... In contrast, the binding of eIF1A to free 40 S ribosomes as well as to the 40 S preinitiation complex was stabilized by the presence of both eIF1 and eIF3
Li et al., Shi Yan Sheng Wu Xue Bao 2003 : As the largest subunit, eIF3a mediates most functions of eIF3
Hui et al., J Biol Chem 2003 : These assays examined the effect of p56 on ribosome dissociation, the eIF3.eIF4F interaction, and enhancement of the ternary complex eIF2.GTP.Met-tRNAi formation
Singh et al., J Biol Chem 2004 : Physical association of eukaryotic initiation factor (eIF) 5 carboxyl-terminal domain with the lysine-rich eIF2beta segment strongly enhances its binding to eIF3
Harris et al., EMBO J 2006 : mTOR dependent stimulation of the association of eIF4G and eIF3 by insulin ... Here, we present evidence that mTOR interacts directly with eIF3 and that mTOR controls the association of eIF3 and eIF4G ... This novel effect was blocked by rapamycin and other inhibitors of mTOR , and it required neither eIF4E binding to eIF4G nor eIF3 binding to the 40S ribosomal subunit
Nielsen et al., Mol Cell Biol 2006 : Several findings indicate that the rnp1 lesion decreases recruitment of eIF3 to the 40S subunit by HCR1 : ( i ) rnp1 strongly impairs the association of HCR1 with PRT1 without substantially disrupting the eIF3 complex ; ( ii ) rnp1 impairs the 40S binding of eIF3 more so than the 40S binding of HCR1 ; ( iii ) overexpressing HCR1-R215I decreases the Ts ( - ) phenotype and increases 40S bound eIF3 in rnp1 cells ; ( iv ) the rnp1 Ts ( - ) phenotype is exacerbated by tif32-Delta6, which eliminates a binding determinant for HCR1 in TIF32 ; and ( v ) hcr1Delta impairs 40S binding of eIF3 in otherwise wild-type cells
Damoc et al., Mol Cell Proteomics 2007 : The eIF3 complex also prevents premature association of the 40 and 60 S ribosomal subunits and interacts with other initiation factors involved in start codon selection
Morris et al., EMBO Rep 2007 : From these observations, we propose that INT6 , in association with eIF3 , is involved in routing specific mRNAs for degradation
Pestova et al., EMBO J 2008 : Although 48S complexes assembled both by eIF2/eIF3- and eIF5B/eIF3 mediated Met-tRNA ( iMet ) recruitment were destabilized by eIF1, dissociation of 48S complexes formed with eIF2 could be out competed by efficient subunit joining
Shi et al., FEBS Lett 2009 : Phosphorylation of eIF3f enhances the association of eIF3f with the core eIF3 subunits during apoptosis
Mitchell et al., Mol Cell 2010 : We show that eIF3 and the eIF4 factors not only stabilize binding of mRNA to the PIC , they also dramatically increase the rate of recruitment
Lane et al., PloS one 2013 : Importantly, eIF3a positively regulated NDRG1 expression and negatively regulated p27 ( kip1 ) expression during iron depletion ... Importantly, eIF3a positively regulated NDRG1 expression and negatively regulated p27 ( kip1 ) expression during iron depletion
Wang et al., Hepatology 2013 (Carcinoma, Hepatocellular...) : In addition, eIF3I interaction with Akt1 prevented PP2A dephosphorylation of Akt1 and resulted in constitutively active Akt1 oncogenic signaling
Checkley et al., J Biol Chem 1981 : The highly purified wheat germ eIF-3 does not prevent the association of wheat germ 40S and 60 S ribosomal subunits to a significant extent
Pain et al., J Biol Chem 1980 (Carcinoma, Ehrlich Tumor) : Factor eIF-3 also stimulates [ 40 S.Met-tRNAfMet ] formation in the cell extracts but does not abolish the difference between fed and starved preparations